Results 91 to 100 of about 841,611 (282)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

From isomorphism to polymorphism: connecting interzeolite transformations to structural and graph similarity

, 2018
Zeolites are nanoporous crystalline materials with abundant industrial applications. Despite sustained research, only 235 different zeolite frameworks have been realized out of millions of hypothetical ones predicted by computational enumeration ...
Gomez-Bombarelli, Rafael, Jensen, Zach, Olivetti, Elsa A., Schwalbe-Koda, Daniel   +3 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

The rank of a complex unit gain graph in terms of the rank of its underlying graph [PDF]

Journal of Combinatorial Optimization, 2019
Let $ =(G, )$ be a complex unit gain graph (or $\mathbb{T}$-gain graph) and $A( )$ be its adjacency matrix, where $G$ is called the underlying graph of $ $. The rank of $ $, denoted by $r( )$, is the rank of $A( )$. Denote by $ (G)=|E(G)|-|V(G)|+ (G)$ the dimension of cycle spaces of $G$, where $|E(G)|$, $|V(G)|$ and $ (G)$ are the number of
Yong Lu, Ligong Wang, Qiannan Zhou
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Analyzing Traffic Problem Model With Graph Theory Algorithms

, 2015
This paper will contribute to a practical problem, Urban Traffic. We will investigate those features, try to simplify the complexity and formulize this dynamic system.
Tan, Yong
core   +1 more source

Secure Evaluation of Knowledge Graph Merging Gain

, 2021
Finding out the differences and commonalities between the knowledge of two parties is an important task. Such a comparison becomes necessary, when one party wants to determine how much it is worth to acquire the knowledge of the second party, or similarly when two parties try to determine, whether a collaboration could be beneficial.
Eichenberger, Leandro, Cochez, Michael, Heitmann, Benjamin, Decker, Stefan   +3 more
openaire   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Minimum Cost Multicast with Decentralized Sources [PDF]

, 2012
In this paper we study the multisource multicast problem where every sink in a given directed acyclic graph is a client and is interested in a common file.
Gastpar, Michael, Milosavljevic, Nebojsa, Pawar, Sameer, Ramchandran, Kannan, Rouayheb, Salim El   +4 more
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source