Results 91 to 100 of about 3,761,116 (301)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Context-Aware Knowledge Graph Learning for Point-of-Interest Recommendation
ISPRS International Journal of Geo-InformationExisting point-of-interest (POI) recommendation methods often fail to capture complex contextual dependencies and suffer from severe data sparsity in location-based social networks (LBSNs).
Yan Zhou +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Fuzzy Computational Analysis of Fuzzy Tadpole Graph
Journal of MathematicsIn this paper, we explore the application of fuzzy topological indices to the fuzzy tadpole graph TA,B, a hybrid structure that combines the cyclic and path-like components within a fuzzy framework.
Shama Liaqat +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Graph Combinatorial Optimization Problems for Blockchain Transaction Network Analysis
MathematicsOpen data makes it possible to gain insights into the transaction patterns of blockchain projects. These patterns can be modeled as transaction networks, which support a wide range of analytical techniques.
Michael Palk, Stefan Voß
doaj +1 more source
Query-Focused Personalized Citation Recommendation With Mutually Reinforced Ranking
IEEE Access, 2018 Many state-of-the-art citation recommendation methods have been proposed for finding a list of reference papers for a given manuscript, among which the graph-based method has gained particular attention, due to its flexibility for incorporating various ...
Dejun Mu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source