Clinical significance of serum galactose-deficient immunoglobulin A1 for detection of recurrent immunoglobulin A nephropathy in kidney transplant recipients [PDF]
Kidney Research and Clinical Practice, 2021 Background Recurrent glomerulonephritis (GN) is a common cause of allograft loss in kidney transplantation (KT), the most frequent of which is immunoglobulin A (IgA) nephropathy (IgAN).
Woo Yeong Park +4 more
doaj +1 more source
The Combined Role of Galactose-Deficient IgA1 and Streptococcal IgA-Binding M Protein in Inducing IL-6 and C3 Secretion from Human Mesangial Cells: Implications for IgA Nephropathy. [PDF]
, 2014 IgA nephropathy (IgAN) is characterized by mesangial cell proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient polymeric IgA1 and C3.
Novak, Jan +7 more
core +1 more source
Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy
Clinical and Developmental Immunology, 2011 Predominant or codominant immunoglobulin (Ig) A deposition in the glomerular mesangium characterizes IgA nephropathy (IgAN). Accumulated glomerular IgA is limited to the IgA1 subclass and usually galactose-deficient.
Mototsugu Tanaka +4 more
doaj +1 more source
Novel lectin-independent approach to detect galactose-deficient IgA1 in IgA nephropathy [PDF]
Nephrology Dialysis Transplantation, 2015 Galactose-deficient IgA1 (Gd-IgA1) is a critical effector molecule in the pathogenesis of IgA nephropathy (IgAN). Although many researchers have measured serum levels of Gd-IgA1 using snail helix aspersa agglutinin (HAA) lectin-based assay, the lectin-dependent assay has some serious problems in robustness.
Yasutake, Junichi +7 more
openaire +2 more sources
In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cells [PDF]
, 2012 IgA nephropathy (IgAN) patients have elevated serum levels of immune complexes consisting of IgA1 with galactose-deficient hinge-region O-glycans (Gd-IgA1) and anti-glycan IgG. These immune complexes deposit in the kidney and activate mesangial cells. To
Rhubell Brown +17 more
core +1 more source
CCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy. [PDF]
PLoS ONE, 2017 IgA nephropathy (IgAN) is the most common primary glomerulonephritis characterized by human mesangial cells (HMC) proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient IgA1.
Guoyuan Lu +6 more
doaj +1 more source
Serum galactose deficient IgA1 levels in patients and controls.
, 2019 Serum galactose deficient IgA1 levels in patients and controls.
Geetika Singh (6519728) +7 more
core +1 more source
PLoS ONE, 2023 The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S.
Taro Misaki +11 more
doaj +2 more sources
A case of paraneoplastic IgA nephropathy with glomerular capillary IgA and galactose-deficient IgA1 deposition. [PDF]
CEN Case Rep, 2023 Paraneoplastic IgA nephropathy (IgAN) is an underrecognized condition in which malignancy manifests as symptoms of IgAN, and it remains controversial regarding their mechanistic relation between IgAN and malignancy. Herein, we report a case of a 68-year-old Japanese man with glottic cancer who developed nephrotic syndrome as a clinical manifestation of
Isogai E +5 more
europepmc +3 more sources
IgA Nephropathy: Beyond the Half-Century
Medicina, 2023 In 1968, Jean Berger first introduced the medical world to IgA nephropathy (IgAN). Fifty-five years later, its pathogenesis is still unclear, but treatments such as renin–angiotensin–aldosterone system inhibitors (RAAS-Is), tonsillectomies, and ...
Yoshio Shimizu +2 more
doaj +1 more source