Results 1 to 10 of about 90,553 (117)

O-glycosylation of SARS-CoV-2 spike protein by host O-glycosyltransferase strengthens its trimeric structure [PDF]

Acta Biochimica et Biophysica Sinica
Protein O-glycosylation, also known as mucin-type O-glycosylation, is one of the most abundant glycosylation in mammalian cells. It is initially catalyzed by a family of polypeptide GalNAc transferases (ppGalNAc-Ts).
Xu Zhijue, Zhang Han, Tian Jiaqi, Ku Xin, Wei Rumeng, Hou Jingli, Zhang Can, Yang Fang, Zou Xia, Li Yang, Kaji Hiroyuki, Tao Sheng-Ce, Kuno Atsushi, Yan Wei, Da Lin-Tai, Zhang Yan   +15 more
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O‐glycosylation in viruses: A sweet tango [PDF]

mLife
O‐glycosylation is an ancient yet underappreciated protein posttranslational modification, on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even cancer.
Annan Ming, Jianxin Zhao, Yihan Liu, Yibo Wang, Xiaohui Wang, Jing Li, Leiliang Zhang   +6 more
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GALNT3 is a novel target driving lymphomagenesis via O-glycosylation of FGFR2 [PDF]

Cell Communication and Signaling
Despite the dual roles of GALNT3 in various cellular processes in tumorigenesis of solid tumors, the clinical and biological significance of GALNT3 in lymphomagenesis remains largely unknown.
Ruixin Sun, Wenhan Wang, Yixuan Gao, Kasimujiang Aximujiang, Yan Li, Agida Innocent, Zizhen Xu, Jiao Ma   +7 more
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An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease

Frontiers in Molecular Biosciences, 2021
The cardiovascular system is a complex and well-organized system in which glycosylation plays a vital role. The heart and vascular wall cells are constituted by an array of specific receptors; most of them are N- glycosylated and mucin-type O ...
Karen Julissa Loaeza-Reyes, Karen Julissa Loaeza-Reyes, Edgar Zenteno, Adriana Moreno-Rodríguez, Rafael Torres-Rosas, Liliana Argueta-Figueroa, Liliana Argueta-Figueroa, Roberta Salinas-Marín, Lizet Monserrat Castillo-Real, Socorro Pina-Canseco, Yobana Pérez Cervera, Yobana Pérez Cervera   +11 more
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A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization [PDF]

Open Biology, 2014
Campylobacter jejuni is an important cause of human foodborne gastroenteritis; strategies to prevent infection are hampered by a poor understanding of the complex interactions between host and pathogen. Previous work showed that C.
Jafar Mahdavi, Necmettin Pirinccioglu, Neil J. Oldfield, Elisabet Carlsohn, Jeroen Stoof, Akhmed Aslam, Tim Self, Shaun A. Cawthraw, Liljana Petrovska, Natalie Colborne, Carina Sihlbom, Thomas Borén, Karl G. Wooldridge, Dlawer A. A. Ala'Aldeen   +13 more
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Deciphering the O-Glycosylation of HKU1 Spike Protein With the Dual-Functional Hydrophilic Interaction Chromatography Materials

Frontiers in Chemistry, 2021
HKU1 is a human beta coronavirus and infects host cells via highly glycosylated spike protein (S). The N-glycosylation of HKU1 S has been reported.
Yun Cui, Xuefang Dong, Xiaofei Zhang, Cheng Chen, Dongmei Fu, Xiuling Li, Xinmiao Liang   +6 more
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Abnormal B cell glycosylation in autoimmunity: A new potential treatment strategy

Frontiers in Immunology, 2022
Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) are two autoimmune diseases characterised by the production of pathogenic autoreactive antibodies. Their aetiology is poorly understood. Nevertheless, they have been shown to involve
Marie Morel, Pierre Pochard, Pierre Pochard, Wiam Echchih, Maryvonne Dueymes, Maryvonne Dueymes, Cristina Bagacean, Cristina Bagacean, Sandrine Jousse-Joulin, Sandrine Jousse-Joulin, Valérie Devauchelle-Pensec, Valérie Devauchelle-Pensec, Divi Cornec, Divi Cornec, Christophe Jamin, Christophe Jamin, Jacques-Olivier Pers, Jacques-Olivier Pers, Anne Bordron   +18 more
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GlypNirO: An automated workflow for quantitative N- and O-linked glycoproteomic data analysis

Beilstein Journal of Organic Chemistry, 2020
Mass spectrometry glycoproteomics is rapidly maturing, allowing unprecedented insights into the diversity and functions of protein glycosylation. However, quantitative glycoproteomics remains challenging.
Toan K. Phung, Cassandra L. Pegg, Benjamin L. Schulz   +2 more
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An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag Short title: Controlled bioconjugation via O-glycan engineering

mAbs, 2021
Bioconjugates are an important class of therapeutic molecules. To date, O-glycan-based metabolic glycoengineering has had limited use in this field, due to the complexities of the endogenous O-glycosylation pathway and the lack of an O-glycosylation ...
Thomas V. Murray, Kasia Kozakowska-McDonnell, Adam Tibbles, Annabel Taylor, Daniel Higazi, Emmanuel Rossy, Alessandra Rossi, Sivaneswary Genapathy, Giulia Tamburrino, Nicola Rath, Natalie Tigue, Vivian Lindo, Tristan Vaughan, Monika A. Papworth   +13 more
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Structural characteristics around O-glycosylation sites in mammalian proteins

Journal of Biomechanical Science and Engineering, 2014
The structural characteristic that O-glycan sugars prefer to bind to the regions forming β-strand structures is reported in this paper. While N-acetylglucosamine (GlcNAc) and mannose (Man) modification sites were contained in β-strand structures, fucose (
Kenji ETCHUYA, Yuri MUKAI
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