O‐glycosylation in viruses: A sweet tango [PDF]
mLifeO‐glycosylation is an ancient yet underappreciated protein posttranslational modification, on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even cancer.
Annan Ming +6 more
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O-glycosylation of SARS-CoV-2 spike protein by host O-glycosyltransferase strengthens its trimeric structure [PDF]
Acta Biochimica et Biophysica SinicaProtein O-glycosylation, also known as mucin-type O-glycosylation, is one of the most abundant glycosylation in mammalian cells. It is initially catalyzed by a family of polypeptide GalNAc transferases (ppGalNAc-Ts).
Xu Zhijue +15 more
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Mucin-Type O-Glycosylation in Gastric Carcinogenesis [PDF]
Biomolecules, 2016 Mucin-type O-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. Modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their glycan products constitute well-established molecular hallmarks of disease state.
Henrique Duarte +5 more
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GALNT3 is a novel target driving lymphomagenesis via O-glycosylation of FGFR2 [PDF]
Cell Communication and SignalingDespite the dual roles of GALNT3 in various cellular processes in tumorigenesis of solid tumors, the clinical and biological significance of GALNT3 in lymphomagenesis remains largely unknown.
Ruixin Sun +7 more
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Database Analysis of O-Glycosylation Sites in Proteins [PDF]
Biophysical Journal, 2001 Statistical analysis was carried out to study the sequential aspects of amino acids around the O-glycosylated Ser/Thr. 992 sequences containing O-glycosylated Ser/Thr were selected from the O-GLYCBASE database of O-glycosylated proteins. The frequency of occurrence of amino acid residues around the glycosylated Ser/Thr revealed that there is an ...
Hema Thanka Christlet, T., Veluraja, K.
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N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation
Molecular & Cellular Proteomics, 2018 Human C1-inhibitor (C1-Inh) is a serine protease inhibitor and the major regulator of the contact activation pathway as well as the classical and lectin complement pathways. It is known to be a highly glycosylated plasma glycoprotein. However, both the structural features and biological role of C1-Inh glycosylation are largely unknown.
Stavenhagen, K. +8 more
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GlycoIP: an integrated platform for simultaneous and site-specific N/O-glycosylation analysis of human semen [PDF]
Frontiers in ChemistryProtein glycosylation plays a pivotal role in human semen, influencing various processes, such as spermatogenesis, maturation, sperm motility, capacitation, and fertilization.
Gaoshu Yan +5 more
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An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease
Frontiers in Molecular Biosciences, 2021 The cardiovascular system is a complex and well-organized system in which glycosylation plays a vital role. The heart and vascular wall cells are constituted by an array of specific receptors; most of them are N- glycosylated and mucin-type O ...
Karen Julissa Loaeza-Reyes +11 more
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A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization [PDF]
Open Biology, 2014 Campylobacter jejuni is an important cause of human foodborne gastroenteritis; strategies to prevent infection are hampered by a poor understanding of the complex interactions between host and pathogen. Previous work showed that C.
Jafar Mahdavi +13 more
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Frontiers in Chemistry, 2021 HKU1 is a human beta coronavirus and infects host cells via highly glycosylated spike protein (S). The N-glycosylation of HKU1 S has been reported.
Yun Cui +6 more
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