Results 41 to 50 of about 10,478,036 (300)

Sugar activation and glycosylation in Plasmodium [PDF]

, 2015
TKS thanks previous funding from the Wellcome Trust (093228), SUSLA and BBSRC, and current funding from MRC (MR/M020118/1) and European Community’s Seventh Framework Programme under grant agreement No. 602773 (Project KINDRED). MC, JAR and LI are members
Smith, Terry K., Smith, Terry K, Izquierdo Lázaro, Luis, João A. Rodrigues, Rodrigues, João A., Cova, Marta, Marta Cova, Terry K. Smith, Izquierdo, Luis, Luis Izquierdo   +9 more
core   +1 more source

Data of ESI mass spectra of apoCIII from an individual with normal O-glycosylation

, 2022
Text data of Fig. 2 ESI mass spectra of apoCIII from an individual with normal O-glycosylation. (a) Multiply-charged ion mass spectrum. Charge state is indicated above each isoform.
Nobuhiko Okamoto (459417), Yoshinao Wada (1398244)   +1 more
core   +1 more source

An etanercept O-glycovariant with enhanced potency

Molecular Therapy: Methods & Clinical Development, 2022
Most therapeutic proteins are glycosylated with N-glycans and/or O-glycans. N-glycans on therapeutic proteins have been extensively studied for their control strategy and impact on drug product quality.
Thomas G. Biel, Talia Faison, Alicia M. Matthews, Guozhang Zou, Uriel Ortega-Rodriguez, Melissa A. Pegues, Nicole Azer, Fabiola Gomez, Sarah Johnson, Sarah Rogstad, Kang Chen, Hang Xie, Cyrus Agarabi, V. Ashutosh Rao, Tongzhong Ju   +14 more
doaj   +1 more source

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. [PDF]

, 2010
N-linked glycosylation is the most frequent modification of secreted and membrane-bound proteins in eukaryotic cells, disruption of which is the basis of the congenital disorders of glycosylation (CDGs).
Hudson H. Freeze, Silhavy, J.L., Christian R.H. Raetz, Al-Gazali, Lihadh, Swistun, Dominika, Dusica Babovic-Vuksanovic, Guan, Z., Blümel, Peter, Sykut-Cegielska, J., Hans van Bokhoven, Bokhoven, J.H.L.M. van, Ludwig Lehle, Lehle, Ludwig, Wevers, R.A., Al-Gazali, L., Houliston, S., Dobyns, W.B., Bassam R. Ali, Lefeber, D.J., Ali, Bassam R., Raetz, Christian R.H., Dirk J. Lefeber, Guan, Ziqiang, Ron A. Wevers, Hans Hombauer, Maciej Adamowicz, Jolanta Sykut-Cegielska, Stephanie L. Bielas, Ng, B.G., Freeze, H.H., Ewa Swiezewska, Wevers, Ron A., William B. Dobyns, Gleeson, Joseph G., Bobby G. Ng, Cantagrel, Vincent, Ng, Bobby G., Swiezewska, Ewa, Lefeber, Dirk J., De Brouwer, Arjan P., Houliston, Scott, Adamowicz, M., Silhavy, Jennifer L., Lihadh Al-Gazali, Ziqiang Guan, Éva Morava, Dobyns, William B., Adamowicz, Maciej, Morava, E., Babovic-Vuksanovic, Dusica, Raetz, C.R., Vincent Cantagrel, Lehle, L., Hombauer, H., Scott Houliston, Freeze, Hudson H., Jennifer L. Silhavy, Swistun, D., Blumel, P., Babovic-Vuksanovic, D., Cantagrel, V., Gleeson, J.G., Peter Blümel, Sykut-Cegielska, Jolanta, Arjan P. De Brouwer, Morava, Éva, Joseph G. Gleeson, Brouwer, A.P.M. de, van Bokhoven, Hans, Swiezewska, E., Hombauer, Hans, Dominika Swistun, Bielas, S.L., Ali, B.R., Bielas, Stephanie L.   +74 more
core   +1 more source

Mass spectrometry-based approach for development of biomarkers in IgA nephropathy: a pilot trial

Fujita Medical Journal, 2018
IgA1 with galactose (Gal)-deficient hinge-region (HR) O-glycans (Gd-IgA1) plays a key role in IgA nephropathy (IgAN), and the serum level of Gd-IgA1 is elevated in the majority of IgAN patients.
Ayako Kondo, Kazuo Takahashi, Hisateru Yamaguchi, Yuri Yoshida, Tomohiro Mizuno, Kazuki Nakajima, Hiroki Hayashi, Shigehisa Koide, Daijo Inaguma, Midori Hasegawa, Yoshiyuki Hiki, Yukio Yuzawa   +11 more
doaj   +1 more source

Data of Deconvoluted mass spectra of apoCIII from CDG patients with abnormal O-glycosylation

, 2022
Text data of Fig. 7 Deconvoluted mass spectra of apoCIII from CDG patients with abnormal O-glycosylation. (a, b) ATP6V0A2-CDG, (c) TRAPPC11-CDG, (d) SLC35A1-CDG.
Nobuhiko Okamoto (459417), Yoshinao Wada (1398244)   +1 more
core   +1 more source

Characterization of the O-Glycoproteome of Porphyromonas gingivalis

Microbiology Spectrum, 2022
Porphyromonas gingivalis is an important human pathogen and also a model organism for the Bacteroidetes phylum. O-glycosylation has been reported in this phylum with findings that include the O-glycosylation motif, the structure of the O-glycans in a few
Paul D. Veith, Mikio Shoji, Nichollas E. Scott, Eric C. Reynolds   +3 more
doaj   +1 more source

Glycosylation of viral proteins: Implication in virus–host interaction and virulence

Virulence, 2022
Glycans are among the most important cell molecular components. However, given their structural diversity, their functions have not been fully explored. Glycosylation is a vital post-translational modification for various proteins.
Tingting Feng, Jinyu Zhang, Zhiqian Chen, Wen Pan, Zhengrong Chen, Yongdong Yan, Jianfeng Dai   +6 more
doaj   +1 more source

Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis

Frontiers in Immunology, 2018
Post-translational modifications such as glycosylation play an important role in the functions of homeostatic proteins, and are critical driving factors of several diseases; however, the role of glycosylation in autoimmune hepatitis is poorly understood.
Xiaohua Hao, Yufeng Li, Jianwen Wang, Jiali Ma, Shuli Zhao, Xiaohui Ye, Lingling He, Junru Yang, Meixin Gao, Fan Xiao, Hongshan Wei   +10 more
doaj   +1 more source

Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes

International Journal of Microbiology, 2010
Recent years have witnessed a rapid growth in the number and diversity of prokaryotic proteins shown to carry N- and/or O-glycans, with protein glycosylation now considered as fundamental to the biology of these organisms as it is in eukaryotic systems ...
Anne Dell, Alaa Galadari, Federico Sastre, Paul Hitchen   +3 more
doaj   +1 more source