Results 61 to 70 of about 14,762,033 (298)

Computational Prediction of N- and O-Linked Glycosylation Sites for Human and Mouse Proteins

, 2022
Protein glycosylation is one of the most complex posttranslational modifications (PTM) that play a fundamental role in protein function. Identification and annotation of these sites using experimental approaches are challenging and time consuming. Hence,
Campbell, M, Taherzadeh, G, Zhou, Y
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Heterogeneous glycosylation and methylation of the Aeromonas caviae flagellin

MicrobiologyOpen, 2022
Bacterial swimming is mediated by the rotation of a flagellar filament. Many bacteria are now known to be able to O‐glycosylate their flagellins, the proteins that make up the flagellar filament.
Rebecca C. Lowry, Laila Allihaybi, Jennifer L. Parker, Narciso A. S. Couto, Graham P. Stafford, Jonathan G. Shaw   +5 more
doaj   +1 more source

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]

, 2010
Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Paul S Sharp, Dominic J. Wells, Ke Liu, Susan C Brown, Sharp, P S, Dominic J Wells, Cirak, S., Sebahattin Cirak, Wells, DJ, Paul S. Sharp, Muntoni, F., Susan C. Brown, Wells, D J, Brockington, M., Cirak, S, Liu, K., Brockington, M, Torelli, S, Brown, SC, Sharp, PS, Muntoni, F, Brown, S C, Sharp, P.S., Torelli, S., Liu, K, Wells, D.J., Silvia Torelli, Brockington, M A, Francesco Muntoni, Martin Brockington, Brown, S.C.   +30 more
core   +1 more source

Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes [PDF]

, 2020
Autoantibody signatures of circulating mucin fragments stem from cancer tissues, and microenvironments are promising biomarkers for cancer diagnosis and therapy.
Yokoi, Yasuhiro, Hinou, Hiroshi [0000-0003-2223-7300], Matsushita, Takahiko [0000-0001-9741-3722], Matsuoka, Koji, Nouso, Kazuhiro, Nishimura, Shin-Ichiro, Wakui, Hajime, Garcia-Martin, Fayna [0000-0001-9118-3874], Kamiyama, Toshiya, Taketomi, Akinobu, Hayakawa, Shun   +10 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells

Cell Reports, 2019
Summary: O-GalNAc glycosylation is initiated in the Golgi by glycosyltransferases called GALNTs. Proteomic screens identified >600 O-GalNAc-modified proteins, but the biological relevance of these modifications has been difficult to determine.
Deepthi Raghu, Robert J. Mobley, Noha A.M. Shendy, Charles H. Perry, Amy N. Abell   +4 more
doaj   +1 more source

Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells. [PDF]

, 2012
C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C.
Tilo Biedermann (116048), Jeanette Wagener (116035), Weig, Michael S., Susanne Kaesler (116042), Jeanette Wagener, Bader, Oliver, Schaller, Martin, Albert D. de Boer (116041), Naglik, Julian R., Naglik, Julian R, Piet W. J. de Groot (116040), Daniela Mailänder-Sanchez (116045), Weindl, Günther, Julian R Naglik, Hans Christian Korting (116050), Günther Weindl, Martin Schaller, Julian R. Naglik (116049), Selvam Thavaraj (116043), Albert D de Boer, Oliver Bader, Hans Christian Korting, de Boer, Albert D, Albert D. De Boer, Oliver Bader (116044), Claudia Borelli (116046), Selvam Thavaraj, Borelli, Claudia, Daniela Mailänder-Sanchez, Susanne Kaesler, Günther Weindl (116038), Biedermann, Tilo, Michael Weig, Michael Weig (116047), Claudia Borelli, de Boer, Albert D., Weindl, Guenther, Mailaender-Sanchez, Daniela, Julian R. Naglik, Kaesler, Susanne, de Groot, Piet W. J., Thavaraj, Selvam, Korting, Hans Christian, Mailänder-Sanchez, Daniela, Apoptosis Of Epithelial Cells, Piet W. J. De Groot, Martin Schaller (116051), Wagener, Jeanette, Weig, Michael, Tilo Biedermann, Piet W J de Groot, Naglik, Julian R; id_orcid, de Groot, Piet W J, Bader Oliver, Biedermann Tilo, Naglik Julian R., Weig Michael, Korting Hans Christian, Schaller Martin, de Groot Piet W. J., Kaesler Susanne, Mailänder-Sanchez Daniela, Borelli Claudia, Mailänder-Sánchez, Daniela Isabel, Thavaraj Selvam, Weindl Günther, Wagener Jeanette, de Boer Albert D.   +67 more
core   +1 more source

An Interactive View of Glycosylation

, 2022
The present chapter focuses on the interactive and explorative aspects of bioinformatics resources that have been recently released in glycobiology. The comparative analysis of data in a field where knowledge is scattered, incomplete, and disconnected ...
Mariethoz, J., Packer, N. H., Lisacek, F., Karlsson, Niclas G.,, Alocci, D.   +4 more
core   +1 more source

Mucin-Type O-Glycosylation in Invertebrates [PDF]

Molecules, 2015
O-Glycosylation is one of the most important posttranslational modifications of proteins. It takes part in protein conformation, protein sorting, developmental processes and the modulation of enzymatic activities. In vertebrates, the basics of the biosynthetic pathway of O-glycans are already well understood.
openaire   +3 more sources