Results 71 to 80 of about 14,762,033 (298)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Biological Functions of Glycosylation and Their Application in Glycoengineered Therapeutics
ChemEngineeringGlycosylation is the most common post-translational modification in the human proteome, with over half of all human proteins bearing covalently attached glycans.
Corbyn Kubalek +7 more
doaj +1 more source
, 2013 Two-pore domain potassium (K2P) channels play fundamental roles in cellular processes by enabling a constitutive leak of potassium from cells in which they are expressed, thus influencing cellular membrane potential and activity.
Roncoroni, Laura +5 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu +10 more
wiley +1 more source
FoodsAlthough Hylocereus polyrhizus pulp residues polysaccharides (HPPP) have shown potential in improving metabolic disorders and intestinal barrier function, the mechanism by which they exert their effects through regulating O-glycosylation modifications in
Guanghui Li +7 more
doaj +1 more source
Analysing the Glycosylation Profile of Triple Negative Breast Cancer [PDF]
Protein glycosylation is a sequential process that involves many enzymes and aids in protein stability and cell signalling. Protein glycosylation is altered in cancer and can increase its invasive and metastatic potential.
Sutherland, Shannon Theresa
core +1 more source
Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis
Advanced Materials, EarlyView.Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne +12 more
wiley +1 more source
Refining the genetics of muscular dystrophies with defective glycosylation of dystroglycan [PDF]
, 2010 The aberrant glycosylation of α-dystroglycan is associated with a subset of clinically heterogeneous muscular dystrophies collectively referred to as dystroglycanopathies.
Godfrey, C.
core
, 2017 Core 1 beta 1,3-galactosyltransferase (C1GALT1) transfers galactose (Gal) to N-acetylgalactosamine (GalNAc) to form Gal beta 1,3GalNAc (T antigen). Aberrant O-glycans, such as T antigen, are commonly found in colorectal cancer.
黃敏銓;洪基翔;賴鴻緒;李伯皇;梁金銅;黃約翰 +1 more
core +1 more source
The influence of flanking sequences on O-glycosylation
Biochemical and Biophysical Research Communications, 1991 The influence of flanking sequences on O-glycosylation of serine and threonine residues was explored by comparison of known acceptor sites. Positions -6, -1 and +3 relative to the site were identified as particularly significant. To test the hypothesis that O-glycosylation could be affected by amino acid sequence, a series of test peptides was made ...
B, O'Connell, L A, Tabak, N, Ramasubbu
openaire +2 more sources