Results 81 to 90 of about 10,478,036 (300)
, 2017 Core 1 beta 1,3-galactosyltransferase (C1GALT1) transfers galactose (Gal) to N-acetylgalactosamine (GalNAc) to form Gal beta 1,3GalNAc (T antigen). Aberrant O-glycans, such as T antigen, are commonly found in colorectal cancer.
黃敏銓;洪基翔;賴鴻緒;李伯皇;梁金銅;黃約翰 +1 more
core +1 more source
GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells
Cell Reports, 2019 Summary: O-GalNAc glycosylation is initiated in the Golgi by glycosyltransferases called GALNTs. Proteomic screens identified >600 O-GalNAc-modified proteins, but the biological relevance of these modifications has been difficult to determine.
Deepthi Raghu +4 more
doaj +1 more source
The influence of flanking sequences on O-glycosylation
Biochemical and Biophysical Research Communications, 1991 The influence of flanking sequences on O-glycosylation of serine and threonine residues was explored by comparison of known acceptor sites. Positions -6, -1 and +3 relative to the site were identified as particularly significant. To test the hypothesis that O-glycosylation could be affected by amino acid sequence, a series of test peptides was made ...
B, O'Connell, L A, Tabak, N, Ramasubbu
openaire +2 more sources
Mucin-type O-Glycosylation during Development [PDF]
Journal of Biological Chemistry, 2013 Mucin-type O-glycosylation is an evolutionarily conserved protein modification present on membrane-bound and secreted proteins. Aberrations in O-glycosylation are responsible for certain human diseases and are associated with disease risk factors. Recent studies have demonstrated essential roles for mucin-type O-glycosylation in protein secretion ...
Duy T, Tran, Kelly G, Ten Hagen
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Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Advanced Materials, EarlyView.Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
Advanced Materials, EarlyView.A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk +7 more
wiley +1 more source
Quantitative characterization of O-GalNAc glycosylation
, 2021 O-GalNAc type glycosylation is an abundant and complex protein modification. Recent developments in mass spectrometry resulted in significant success in quantitative analysis of O-GalNAc glycosylation.
Vakhrushev, Sergey Y. +3 more
core +1 more source
FoodsAlthough Hylocereus polyrhizus pulp residues polysaccharides (HPPP) have shown potential in improving metabolic disorders and intestinal barrier function, the mechanism by which they exert their effects through regulating O-glycosylation modifications in
Guanghui Li +7 more
doaj +1 more source
O-glycosylation and its role in therapeutic proteins
Bioscience Reports, 2022 AbstractProtein glycosylation is ubiquitous throughout biology. From bacteria to humans, this post translational modification with sophisticated carbohydrate structures plays a profound role in the interaction of proteins with cells and changes the physiochemical properties of the proteins that carry them.
Nicole Thompson, Warren Wakarchuk
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Advanced Science, EarlyView.Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu +12 more
wiley +1 more source