Results 101 to 110 of about 14,762,033 (298)
Transient glyco-engineering to produce recombinant IgA1 with defined N- and O-glycans in plants
Frontiers in Plant Science, 2016 The production of therapeutic antibodies to combat pathogens and treat diseases such as cancer is of great interest for the biotechnology industry. The recent development of plant-based expression systems has demonstrated that plants are well-suited for ...
Martina eDicker +7 more
doaj +1 more source
Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
wiley +1 more source
, 2022 Immune checkpoint therapy (ICT) with a monoclonal antibody (MAb) against programmed cell death protein 1 (PD-1) is a powerful clinical treatment for tumors.
Dan Lu (135836) +10 more
core +1 more source
Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
Advanced Science, EarlyView.BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley +1 more source
A Novel model for Mucin-type O-glycosylation sites Prediction
, 2010 Glycosylation, one of the most common protein post-translational modifications, is involved in a variety of important biological processes, including protein stability, solubility, secretion of signal, extracellular recognition, regulation of ...
艾纯芝, 周坤, 杨凌
core
LINC00173 promotes Wilms’ tumor progression through MGAT1-mediated MUC3A N-glycosylation
, 2022 Recent studies have unveiled that LINC00173 promotes small cell lung cancer progression. However, LINC00173 has not been studied in Wilms’ tumor (WT).
Qingliang Zhu (12484975) +5 more
core +1 more source
Advanced Science, EarlyView.This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu +6 more
wiley +1 more source
Congenital protein hypoglycosylation diseases
The Application of Clinical Genetics, 2012 Susan E SparksDepartment of Pediatrics, Levine Children's Hospital at Carolinas Medical Center, Charlotte, NC, USA; Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USAAbstract: Glycosylation is an ...
Sparks SE
doaj
Dynamic glycosylation remodeling in neurological disorders
Frontiers in Molecular NeuroscienceGlycosylation, a crucial post-translational modification, involves the covalent attachment of monosaccharides or oligosaccharides to proteins. This process significantly influences protein stability and function.
Dan Xing +8 more
doaj +1 more source
, 2017 Introduction: Glycosylation controls diverse protein functions and regulates various cellular phenotypes. Trophoblast invasion is essential for normal placental development.
許文明;黃敏銓;徐明洸 +1 more
core +1 more source