Results 111 to 120 of about 10,478,036 (300)

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

A Novel model for Mucin-type O-glycosylation sites Prediction

, 2010
Glycosylation, one of the most common protein post-translational modifications, is involved in a variety of important biological processes, including protein stability, solubility, secretion of signal, extracellular recognition, regulation of ...
艾纯芝, 周坤, 杨凌
core  

The cloning , expression and characterisation of bacterial chitin-binding proteins from pseudomonas aeruginosa , serratia marcescens, photorhabdus luminescens and photorhabdus asymbiotica. [PDF]

, 2011
It is well recognised that most proteins are subject to post translational modifications and that these modifications can have specific effects on the biological properties and functions of these proteins.
Larragy, Ruth
core  

beta-1,4-galactosyltransferase III suppresses extravillous trophoblast invasion through modifying beta 1-integrin glycosylation

, 2017
Introduction: Glycosylation controls diverse protein functions and regulates various cellular phenotypes. Trophoblast invasion is essential for normal placental development.
許文明;黃敏銓;徐明洸, Liao, W. -C.;Liu, C. -H.;Chen, C. -H.;Hsu, W. -M.;Liao, Y. -Y.;Chang, H. -M.;Lan, C. -T.;Huang, M. -C.;Shyu, M. -K.   +1 more
core   +1 more source

Transient glyco-engineering to produce recombinant IgA1 with defined N- and O-glycans in plants

Frontiers in Plant Science, 2016
The production of therapeutic antibodies to combat pathogens and treat diseases such as cancer is of great interest for the biotechnology industry. The recent development of plant-based expression systems has demonstrated that plants are well-suited for ...
Martina eDicker, Marc eTschofen, Daniel eMaresch, Julia eKönig, Paloma eJuarez, Diego eOrzaez, Friedrich eAltmann, Richard eStrasser   +7 more
doaj   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

The role of calnexin, calreticulin and heavy chain glycosylation in MHC class I assembly

, 2002
Class I heavy chain (HC) must assemble with β-microglobulin (β2m) and acquire optimal peptide in order to be presented to cytotoxic T cells (CTLs). Calnexin is involved in the initial folding of class I HC and subsequent assembly with β2m.
Adhikari, Raju., Adhikari, Raju
core   +1 more source

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Keeping an eye on congenital disorders of O-glycosylation: a systematic literature review

, 2018
Congenital disorders of glycosylation (CDG) are a rapidly growing family comprising >100 genetic diseases. Some 25 CDG are pure O-glycosylation defects.
Marques-da-Silva, Dorinda, dos Reis Ferreira, V, Jaeken, J., Gole, Glen A., Francisco, Rita, Rita Francisco, Jaeken, Jaak, Coman, D, Francisco, R, Pascoal, C, Francisco, R., Morava, E., Gole, G. A., Coman, D., Dorinda Marques‐da‐Silva, Morava, E, Carlota Pascoal, Glen A. Gole, Pascoal, C., Marques-da-Silva, D, Coman, David, Eva Morava, David Coman, Jaak Jaeken, Pascoal, Carlota, Morava, Eva, Marques-da-Silva, D., Dos Reis Ferreira, Vanessa, Vanessa dos Reis Ferreira, Jaeken, J, Gole, GA   +30 more
core   +1 more source

Diastereoselectivity in Anomeric O-alkylation Glycosylation [PDF]

, 2021
Biosynth AS used anomeric O-alkylation of α-haloacetophenones in their patented total synthesis of anthocyanins from 2006. There were, however, several challenges with stereoselectivity and yields when performing this glycosylation on a large scale.
Naimak, Jørn Holm
core