Results 1 to 10 of about 14,068 (233)
Potential coordination role between O-GlcNAcylation and epigenetics
Protein and Cell, 2017 Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the glycoside hydrolase O-GlcNAcase (OGA) in cells. O-GlcNAcylation often occurs on serine
Donglu Wu, Jingji Jin
exaly +3 more sources
O-GlcNAcylation regulates endometrial decidualization through dual mechanisms: PI3K-AKT axis-mediated phosphorylation and direct modification of FOXO1 [PDF]
Biology DirectBackground Steroid hormone-driven endometrial decidualization involves the differentiation of endometrial stromal cells into decidual cells, which form the decidua for blastocyst implantation.
Qianyi Sun +8 more
doaj +2 more sources
Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
Cardiovascular Diabetology, 2023 Background O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions.
Chidinma A Okolo +6 more
doaj +1 more source
O-GlcNAcylation and its role in the immune system
Journal of Biomedical Science, 2020 O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of nuclear or cytoplasmic proteins by O-GlcNAc transferase (OGT) and which can be ...
Yi-Hsuan Chang, Chia-Lin Weng, Kuo-I Lin
doaj +1 more source
Scientific Reports, 2022 O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification on serine and threonine residues of cytosolic, nuclear and mitochondrial proteins.
Victoria Jiménez-Castillo +12 more
doaj +1 more source
O-GlcNAcase contributes to cognitive function in Drosophila [PDF]
, 2020 Contains fulltext : 219183.pdf (publisher's version ) (Open ...
Catinozzi, Marica +7 more
core +3 more sources
O-GlcNAcylation in Chronic Lymphocytic Leukemia and Other Blood Cancers
Frontiers in Immunology, 2021 In the past decade, aberrant O-GlcNAcylation has emerged as a new hallmark of cancer. O-GlcNAcylation is a post-translational modification that results when the amino-sugar β-D-N-acetylglucosamine (GlcNAc) is made in the hexosamine biosynthesis pathway ...
David E. Spaner +4 more
doaj +1 more source
O‐GlcNAcylation: cellular physiology and therapeutic target for human diseases
MedComm, 2023 O‐linked‐β‐N‐acetylglucosamine (O‐GlcNAcylation) is a distinctive posttranslational protein modification involving the coordinated action of O‐GlcNAc transferase and O‐GlcNAcase, primarily targeting serine or threonine residues in various proteins.
Lin Ye +6 more
doaj +1 more source
Blockage of O-linked GlcNAcylation induces AMPK-dependent autophagy in bladder cancer cells
Cellular & Molecular Biology Letters, 2020 Background High levels of the post-translational modification O-GlcNAcylation (O-GlcNAc) are found in multiple cancers, including bladder cancer. Autophagy, which can be induced by stress from post-translational modifications, plays a critical role in ...
Lu Jin +8 more
doaj +1 more source
Bone Research, 2022 Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation. In inflammatory arthritis such as rheumatoid arthritis (RA), however, increased osteoclast differentiation and activity skew this ...
Yi-Nan Li +20 more
doaj +1 more source