Results 1 to 10 of about 22,517 (154)

Dual functionality of O-GlcNAc transferase is required for Drosophila development [PDF]

Open Biology, 2015
Post-translational modification of intracellular proteins with O-linked N-acetylglucosamine (O-GlcNAc) catalysed by O-GlcNAc transferase (OGT) has been linked to regulation of diverse cellular functions.
Daniel Mariappa, Xiaowei Zheng, Marianne Schimpl, Olawale Raimi, Andrew T. Ferenbach, H.-Arno J. Müller, Daan M. F. van Aalten   +6 more
doaj   +5 more sources

Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling

Cell Reports, 2021
Summary: Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases. However, the roles of Ogt in regulating neurogenesis remain largely unknown.
Xuejun Cheng, Qiang Zhu, Jinyu Zhang
exaly   +3 more sources

Distinct OGT-Binding Sites Promote HCF-1 Cleavage. [PDF]

PLoS ONE, 2015
Human HCF-1 (also referred to as HCFC-1) is a transcriptional co-regulator that undergoes a complex maturation process involving extensive O-GlcNAcylation and site-specific proteolysis.
Tanja Bhuiyan, Patrice Waridel, Vaibhav Kapuria, Vincent Zoete, Winship Herr   +4 more
doaj   +6 more sources

OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis

Autoimmunity
Backgrounds The role of O-GlcNAc transferase (OGT)-induced O-linked N-acetylglucosaminylation (O-GlcNAcylation) has been reported in multiple human diseases. However, its specific functions in osteoarthritis (OA) progression remain undetermined.Objective
Chunlei He
exaly   +3 more sources

Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors

Türk Biyokimya Dergisi, 2021
The aim of this study was to investigate BAP1, OGT and YY1 genes and protein levels in 12 samples (8 males, 4 females) of eyelid tumor tissue with basal cell carcinoma (BCC) and 12 normal control subjects (8 males, 4 females).
Tas Ayca, Gumus Erkan, Ozmen Esma, Erdogan Haydar, Silig Yavuz   +4 more
doaj   +1 more source

Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel

Frontiers in Oncology, 2022
The expression of O-GlcNAc transferase (OGT) and its catalytic product, O-GlcNAcylation (O-GlcNAc), are elevated in many types of cancers, including prostate cancer (PC).
Mingyue Xia, Shuyan Wang, Yannan Qi, Kaili Long, Enjie Li, Lingfeng He, Feiyan Pan, Zhigang Guo, Zhigang Hu   +8 more
doaj   +1 more source

Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). [PDF]

, 2013
O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events.
Chen, Xi, Chen, Yi, Li, Lei, Liu, Pi, Liu, Xiaoyan, Ma, Xiaofeng, Muthana, Musleh M, Sun, Hong, Wang, Peng G, Yan, Hui, Zhang, Lianwen, Zhou, Feng   +11 more
core   +8 more sources

OGT/HIF-2α axis promotes the progression of clear cell renal cell carcinoma and regulates its sensitivity to ferroptosis

iScience, 2023
Summary: O-GlcNAc transferase (OGT) acts in the development of various cancers, but its role in clear cell renal cell carcinoma (ccRCC) remains unclear. In this study, we found that OGT was upregulated in ccRCC and this upregulation was associated with a
Zhou Yang, Xiyi Wei, Chengjian Ji, Xiaohan Ren, Wei Su, Yichun Wang, Jingwan Zhou, Zheng Zhao, Pengcheng Zhou, Kejie Zhao, Bing Yao, Ninghong Song, Chao Qin   +12 more
doaj   +1 more source

Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway

Journal of Neuroinflammation, 2023
Previous studies have shown that Ogt-mediated O-GlcNAcylation is essential for neuronal development and function. However, the function of O-GlcNAc transferase (Ogt) and O-GlcNAcylation in astrocytes remains largely unknown.
Xiaoxue Dong, Liqi Shu, Jinyu Zhang, Xu Yang, Xuejun Cheng, Xingsen Zhao, Wenzheng Qu, Qiang Zhu, Yikai Shou, Guoping Peng, Binggui Sun, Wen Yi, Qiang Shu, Xuekun Li   +13 more
doaj   +1 more source

Does geriatric follow-up visits reduce hospital readmission among older patients discharged to temporary care at a skilled nursing facility: a before-and-after cohort study

BMJ Open, 2021
Introduction Hospital readmission is a burden to patients, relatives and society. Older patients with frailty are at highest risk of readmission and its negative outcomes.Objective We aimed at examining whether follow-up visits by an outgoing ...
Jesper Ryg, Karen Andersen-Ranberg, Katja Thomsen, Anders Fournaise, Lars Erik Matzen   +4 more
doaj   +1 more source