Results 31 to 40 of about 22,588 (217)
Molecular Metabolism, 2022 Objective: The intestine is an important organ for nutrient metabolism via absorption and endocrine systems. Nutrients regulate O-GlcNAcylation, a post-translational modification of various proteins by O-GlcNAc transferase (OGT). We have previously shown
Kimihiro Nishimura +12 more
doaj +1 more source
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation [PDF]
, 2018 Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis.
Bacigalupa, Zachary A. +8 more
core +1 more source
The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities [PDF]
, 2018 O-Linked GlcNAc transferase (OGT) possesses dual glycosyltransferase-protease activities. OGT thereby stably glycosylates serines and threonines of numerous proteins and, via a transient glutamate glycosylation, cleaves a single known substrate-the so ...
Borodkin, Vladimir S. +7 more
core +4 more sources
O-Glcnac Modulates Nasal Inverted Papilloma Progression And Malignancy
International Dental JournalAim or purpose: This study investigated the role of O-GlcNAc glycosylation in nasal inverted papilloma (NIP) pathogenesis and malignant transformation, addressing its understudied mechanistic relevance (Zhao et al., 2016, Laryngoscope 126:E141-7 ...
Sen Wang, Yintao Yu, Fang Wang
doaj +1 more source
Adipocyte OGT governs diet-induced hyperphagia and obesity [PDF]
Nature Communications, 2018 AbstractPalatable foods (fat and sweet) induce hyperphagia, and facilitate the development of obesity. Whether and how overnutrition increases appetite through the adipose-to-brain axis is unclear. O-linked beta-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) couples nutrient cues to O-GlcNAcylation of intracellular proteins at serine/threonine ...
Min-Dian Li +14 more
openaire +3 more sources
PLoS ONE, 2021 Neurodevelopmental disorders such as epilepsy and autism have been linked to an imbalance of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of C.
Nirthieca Suthakaran +5 more
doaj +2 more sources
Microarray Discovery of New OGT Substrates: The Medulloblastoma Oncogene OTX2 Is O-GlcNAcylated [PDF]
, 2014 O-GlcNAc transferase (OGT) is a serine/threonine glycosyltransferase that is essential for development and continues to be critically important throughout life. Understanding OGT’s complex biology requires identifying its substrates.
Kirschner, Marc W. +3 more
core +3 more sources
The nutrient sensor OGT in PVN neurons regulates feeding [PDF]
Science, 2016 When enough isn't enough Overeating and obesity are rapidly becoming worldwide problems. Normally, mice do not overeat—they balance their caloric intake with their caloric needs. Lagerlöf et al.
Olof, Lagerlöf +6 more
openaire +2 more sources
Cell Reports, 2017 Summary: Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases.
Sung-Kyun Park +6 more
doaj +1 more source
Insights into the Ecological Roles and Evolution of Methyl-Coenzyme M Reductase-Containing Hot Spring Archaea [PDF]
, 2019 Several recent studies have shown the presence of genes for the key enzyme associated with archaeal methane/alkane metabolism, methyl-coenzyme M reductase (Mcr), in metagenome-assembled genomes (MAGs) divergent to existing archaeal lineages.
Chen, Ya-Ting +17 more
core +3 more sources