Results 1 to 10 of about 37,371 (251)

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis [PDF]

Cell Reports, 2017
Summary: Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases.
Sung-Kyun Park, Xiaorong Zhou, Kathryn A O'donnell   +2 more
exaly   +5 more sources

Small molecule splicing modulators that disrupt O-GlcNAc homeostasis [PDF]

Nature Communications
O-Linked N-acetylglucosamine (O-GlcNAc) is a nucleocytoplasmic post-translational modification that is tightly regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).
Steven S. Cheng, Alison C. Mody, Amedeo Vetere, Ashwin Govindan, Yewon Lee, Danielle E. Khost, Rohan Narayan, Timothy B. Sackton, Nicholas K. Conrad, Bridget K. Wagner, Christina M. Woo   +10 more
doaj   +2 more sources

O-GlcNAc modification: why so intimately associated with phosphorylation? [PDF]

Cell Communication and Signaling, 2011
Post-translational modification of proteins at serine and threonine side chains by β-N-acetylglucosamine (O-GlcNAc) mediated by the enzyme β-N-acetylglucosamine transferase has been emerging as a fundamental regulatory mechanism encompassing a wide range
Ande Sudharsana R, Mishra Suresh, Salter Neil W   +2 more
doaj   +3 more sources

Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein [PDF]

Journal of Virology
O-GlcNAcylation, a post-translational modification consisting of O-linked N-acetylglucosamine attached to serine and threonine residues, occurs in thousands of cytoplasmic, nuclear, and mitochondrial proteins but has been reported for relatively few ...
Yunliang Zhang, Bernard Moss
doaj   +2 more sources

Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II [PDF]

Genome Biology
Background How reversible glycosylation of DNA-bound proteins acts on transcription remains scarcely understood. O-linked β-N-acetylglucosamine (O-GlcNAc) is the only known form of glycosylation modifying nuclear proteins, including RNA polymerase II ...
Sofia Rucli, Nicolas Descostes, Yulia Ermakova, Urvashi Chitnavis, Jeanne Couturier, Ana Boskovic, Matthieu Boulard   +6 more
doaj   +2 more sources

The post-translational modification O-GlcNAc is a sensor and regulator of metabolism [PDF]

Open Biology
Cells must rapidly adapt to changes in nutrient conditions through responsive signalling cascades to maintain homeostasis. One of these adaptive pathways results in the post-translational modification of proteins by O-GlcNAc.
Murielle M. Morales, Matthew R. Pratt
doaj   +2 more sources

Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program [PDF]

Nature Communications
O-GlcNAc modification is a key cellular signal, but its role in regulating senescence-associated transcription remains poorly understood. Here, we apply a time-resolved chemical genomics strategy to map dynamic O-GlcNAc chromatin-associated proteins ...
Nana Zhang, Ran Zhao, Xiaomin Zhong, Qian Dong, Yajie Liu, Kairan Yu, Lirui Han, Fanxu Meng, Jiaxuan Wu, Qiushi Chen, Xuechen Li, Qingbin Chen, Keren Zhang, Huang Huang, Jianing Zhang, Sijin Wu, Yan Ren, Wei Wang, Yubo Liu   +18 more
doaj   +2 more sources

O-GlcNAc impacts mitophagy via the PINK1-dependent pathway [PDF]

Frontiers in Aging Neuroscience
BackgroundThe accumulation of dysfunctional mitochondria is an early feature of Alzheimer’s disease (AD). The impaired turnover of damaged mitochondria increases reactive oxygen species production and lowers ATP generation, leading to cellular toxicity ...
Ibtihal M. Alghusen, Marisa S. Carman, Heather M. Wilkins, Heather M. Wilkins, Heather M. Wilkins, Taylor A. Strope, Caleb Gimore, Halyna Fedosyuk, Jad Shawa, Sophiya John Ephrame, Aspin R. Denson, Xiaowan Wang, Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Chad Slawson, Chad Slawson   +16 more
doaj   +2 more sources

Dual functionality of O-GlcNAc transferase is required for Drosophila development [PDF]

Open Biology, 2015
Post-translational modification of intracellular proteins with O-linked N-acetylglucosamine (O-GlcNAc) catalysed by O-GlcNAc transferase (OGT) has been linked to regulation of diverse cellular functions.
Daniel Mariappa, Xiaowei Zheng, Marianne Schimpl, Olawale Raimi, Andrew T. Ferenbach, H.-Arno J. Müller, Daan M. F. van Aalten   +6 more
doaj   +1 more source

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila.

PLoS Genetics, 2022
O-GlcNAcylation is a reversible co-/post-translational modification involved in a multitude of cellular processes. The addition and removal of the O-GlcNAc modification is controlled by two conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAc ...
Michaela Fenckova, Villo Muha, Daniel Mariappa, Marica Catinozzi, Ignacy Czajewski, Laura E R Blok, Andrew T Ferenbach, Erik Storkebaum, Annette Schenck, Daan M F van Aalten   +9 more
doaj   +1 more source