Results 1 to 10 of about 20,819 (160)

Dual functionality of O -GlcNAc transferase is required for Drosophila development [PDF]

Open Biology, 2015
Post-translational modification of intracellular proteins with O-linked N-acetylglucosamine (O-GlcNAc) catalysed by O-GlcNAc transferase (OGT) has been linked to regulation of diverse cellular functions.
Daniel Mariappa, Marianne Schimpl, Olawale G Raimi   +2 more
exaly   +6 more sources

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats [PDF]

Open Biology, 2017
O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-translational modification found on hundreds of nucleocytoplasmic proteins in metazoa.
Karim Rafie, Olawale Raimi, Andrew T Ferenbach   +2 more
exaly   +2 more sources

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis

Cell Reports, 2017
Summary: Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases.
Sung-Kyun Park, Xiaorong Zhou, Jennifer J Köhler   +2 more
exaly   +3 more sources

The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix [PDF]

Cell Chemical Biology, 2018
O-linked β-N-acetyl-D-glucosamine (O-GlcNAc) transferase (OGT) regulates protein O-GlcNAcylation, an essential post-translational modification that is abundant in the brain.
Salome Llabres, Andrii Gorelik, Andrew T Ferenbach   +2 more
exaly   +4 more sources

O-GlcNAc transferase plays a non-catalytic role in C. elegans male fertility. [PDF]

PLoS Genetics, 2022
Animal behavior is influenced by the competing drives to maintain energy and to reproduce. The balance between these evolutionary pressures and how nutrient signaling pathways intersect with mating remains unclear.
Daniel Konzman, Tetsunari Fukushige, Mesgana Dagnachew, Michael Krause, John A Hanover   +4 more
doaj   +2 more sources

O-GlcNAc modification: why so intimately associated with phosphorylation? [PDF]

Cell Communication and Signaling, 2011
Post-translational modification of proteins at serine and threonine side chains by β-N-acetylglucosamine (O-GlcNAc) mediated by the enzyme β-N-acetylglucosamine transferase has been emerging as a fundamental regulatory mechanism encompassing a wide range
Ande Sudharsana R, Mishra Suresh, Salter Neil W   +2 more
doaj   +3 more sources

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila.

PLoS Genetics, 2022
O-GlcNAcylation is a reversible co-/post-translational modification involved in a multitude of cellular processes. The addition and removal of the O-GlcNAc modification is controlled by two conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAc ...
Michaela Fenckova, Villo Muha, Daniel Mariappa, Marica Catinozzi, Ignacy Czajewski, Laura E R Blok, Andrew T Ferenbach, Erik Storkebaum, Annette Schenck, Daan M F van Aalten   +9 more
doaj   +1 more source

Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice

Cells, 2021
The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell survival and insulin secretion.
Ramkumar Mohan, Seokwon Jo, Elina Da Sol Chung, Eunice Oribamise, Amber Lockridge, Juan E. Abrahante-Lloréns, Hai-Bin Ruan, Xiao-Yong Yang, Emilyn U. Alejandro   +8 more
doaj   +1 more source

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Frontiers in Neuroscience, 2023
A substantial body of evidence has indicated that intracerebral O-linked N-acetyl-β-D-glucosamine (O-GlcNAc), a generalized post-translational modification, was emerging as an effective regulator of stress-induced emotional and cognitive impairments. Our
Yan Huang, Yan Huang, Yan Huang, Jianhui Wang, Jianhui Wang, Feng Liu, Feng Liu, Chenran Wang, Chenran Wang, Zhiyong Xiao, Zhiyong Xiao, Wenxia Zhou, Wenxia Zhou, Wenxia Zhou   +13 more
doaj   +1 more source

New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth

Frontiers in Chemistry, 2021
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins ...
Matjaž Weiss, Elena M. Loi, Elena M. Loi, Maša Sterle, Cyril Balsollier, Cyril Balsollier, Tihomir Tomašič, Roland J. Pieters, Martina Gobec, Marko Anderluh   +9 more
doaj   +1 more source