Cardiac transcription factor Nkx2.5 is downregulated under excessive O-GlcNAcylation condition. [PDF]
PLoS ONE, 2012 Post-translational modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is linked the development of diabetic cardiomyopathy. We investigated whether Nkx2.5 protein, a cardiac transcription factor, is regulated by O-GlcNAc.
Hoe Suk Kim +3 more
doaj +1 more source
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. [PDF]
, 2019 Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of ...
Albarran, Eddy +8 more
core +1 more source
O-GlcNAcase expression is sensitive to changes in O-GlcNAc homeostasis
Frontiers in Endocrinology, 2014 O-linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification involving an attachment of a single β-N-acetylglucosamine moiety to serine or threonine residues in nuclear and cytoplasmic proteins.
ZHEN eZHANG +4 more
doaj +1 more source
A nexus of lipid and O-Glcnac metabolism in physiology and disease
Frontiers in Endocrinology, 2022 Although traditionally considered a glucose metabolism-associated modification, the O-linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids and is required to maintain lipid homeostasis.
Amber Lockridge, John A. Hanover
doaj +1 more source
Engineering of GlcNAc-1-phosphotransferase for production of highly phosphorylated lysosomal enzymes for enzyme replacement therapy [PDF]
, 2017 Several lysosomal enzymes currently used for enzyme replacement therapy in patients with lysosomal storage diseases contain very low levels of mannose 6-phosphate, limiting their uptake via mannose 6-phosphate receptors on the surface of the deficient ...
Doray, Balraj +3 more
core +3 more sources
The glycosyltransferase EOGT regulates adropin expression in decidualizing human endometrium [PDF]
, 2017 In pregnancy, resistance of endometrial decidual cells to stress signals is critical for the integrity of the feto-maternal interface and, by extension, survival of the conceptus. O-GlcNAcylation is an essential post-translational modification that links
Alam, Mohammad T. +8 more
core +2 more sources
Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases [PDF]
, 2012 Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Boeriu, C.G. +3 more
core +2 more sources
Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel. [PDF]
Front Oncol, 2022 The expression of O-GlcNAc transferase (OGT) and its catalytic product, O-GlcNAcylation (O-GlcNAc), are elevated in many types of cancers, including prostate cancer (PC). Inhibition of OGT serves as a potential strategy for PC treatment alone or combinational therapy. PC is the second common cancer type in male worldwide, for which
Xia M +8 more
europepmc +4 more sources
The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc [PDF]
, 2014 Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space.
Hanson, R.W. +8 more
core +1 more source
Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability. [PDF]
J Biol Chem, 2022 Protein O-GlcNAcylation is a dynamic posttranslational modification that is catalyzed by the enzyme O-GlcNAc transferase (OGT) and is essential for neurodevelopment and postnatal neuronal function. Missense mutations in OGT segregate with a novel X-linked intellectual disability syndrome, the OGT congenital disorder of glycosylation (OGT-CDG).
Mitchell CW +2 more
europepmc +5 more sources