Results 11 to 20 of about 20,888 (214)

X-inactivation normalizes O-GlcNAc Transferase levels and generates an O-GlcNAc-depleted Barr body [PDF]

Frontiers in Genetics, 2014
O-GlcNAc Transferase (OGT) catalyzes protein O-GlcNAcylation, an abundant and dynamic nuclear and cytosolic modification linked to epigenetic regulation of gene expression.
Stéphanie eOlivier-Van Stichelen, John A Hanover   +1 more
doaj   +3 more sources

Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors [PDF]

Bioconjugate Chemistry, 2018
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors.
Andrii Gorelik, Bogachev V. S., Daan M. F. van Aalten, Derossi D., Dong D. L., Karim Rafie, Riccardo Trapannone, Torres C. R., Vladimir S. Borodkin   +8 more
core   +8 more sources

O-GlcNAc transferase is important for homology-directed repair. [PDF]

DNA Repair (Amst), 2022
O-Linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) to serine or threonine residues is a reversible and dynamic post-translational modification. O-GlcNAc transferase (OGT) is the only enzyme for O-GlcNAcylation, and is a potential cancer therapeutic target in combination with clastogenic (i.e., chromosomal breaking) therapeutics.
Ping X, Stark JM.
europepmc   +3 more sources

Exploiting O-GlcNAc dyshomeostasis to screen O-GlcNAc transferase intellectual disability variants. [PDF]

Stem Cell Reports
O-GlcNAcylation is an essential protein modification catalyzed by O-GlcNAc transferase (OGT). Missense variants in OGT are linked to a novel intellectual disability syndrome known as OGT congenital disorder of glycosylation (OGT-CDG). The mechanisms by which OGT missense variants lead to this heterogeneous syndrome are not understood, and no unified ...
Yuan H, Mitchell CW, Ferenbach AT, Bonati MT, Feresin A, Benke PJ, Tan QKG, van Aalten DMF.   +7 more
europepmc   +4 more sources

O-GlcNAc Transferase – An Auxiliary Factor or a Full-blown Oncogene? [PDF]

Molecular Cancer Research, 2021
Abstract The β-linked N-acetyl-d-glucosamine (GlcNAc) is a posttranslational modification of serine and threonine residues catalyzed by the enzyme O-GlcNAc transferase (OGT). Increased OGT expression is a feature of most human cancers and inhibition of OGT decreases cancer cell proliferation.
Itkonen, HM, Loda, M, Mills, IG
openaire   +3 more sources

H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase. [PDF]

Drug Resist Updat, 2023
Drivers of the drug tolerant proliferative persister (DTPP) state have not been well investigated. Histone H3 lysine-4 trimethylation (H3K4me3), an active histone mark, might enable slow cycling drug tolerant persisters (DTP) to regain proliferative capacity.
Ravindran Menon D, Hammerlindl H, Gimenez G, Hammerlindl S, Zuegner E, Torrano J, Bordag N, Emran AA, Giam M, Denil S, Pavelka N, Tan AC, Sturm RA, Haass NK, Rancati G, Herlyn M, Magnes C, Eccles MR, Fujita M, Schaider H.   +19 more
europepmc   +6 more sources

Cardioprotective O-GlcNAc signaling is elevated in murine female hearts via enhanced O-GlcNAc transferase activity. [PDF]

J Biol Chem, 2023
The post-translational modification of intracellular proteins by O-linked β-GlcNAc (O-GlcNAc) has emerged as a critical regulator of cardiac function. Enhanced O-GlcNAcylation activates cytoprotective pathways in cardiac models of ischemia-reperfusion (I/R) injury; however, the mechanisms underpinning O-GlcNAc cycling in response to I/R injury have not
Narayanan B, Sinha P, Henry R, Reeves RA, Paolocci N, Kohr MJ, Zachara NE.   +6 more
europepmc   +3 more sources

The diverging role of O-GlcNAc transferase in corticotroph and somatotroph adenomas. [PDF]

Pituitary
Abstract Purpose Molecular mechanisms involved in the pathogenesis and tumor progression of pituitary adenomas (PA) remain incompletely understood. Corticotroph and somatotroph PA associate a high clinical burden, and despite improved surgical outcomes and medical treatment options, sometimes require multiple surgeries and radiation ...
Gonzalez R, Massman L, Ho S, Luna S, Cheok S, Liang B, Mrachek K, Coss D, Ioachimescu AG, Zwagerman N, Olivier-Van Stichelen S.   +10 more
europepmc   +3 more sources

Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain. [PDF]

PLoS ONE, 2012
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal of O-GlcNAc groups to and from proteins are catalyzed by O-linked N-acetylglucosamine transferase
Ying Liu, Xiaojing Li, Yang Yu, Jianhua Shi, Zhihou Liang, Xiaoqin Run, Yi Li, Chun-ling Dai, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong   +11 more
doaj   +1 more source

O-GlcNAc transferase regulates excitatory synapse maturity [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Neurons in the brain adapt to environmental challenges by rearranging their connections, or synapses, to other neurons. This process is called synaptic plasticity and it is unclear how synaptic plasticity is regulated. Here we show that the enzyme O-GlcNAc transferase (OGT) modulates the maturity of excitatory synapses.
Olof, Lagerlöf, Gerald W, Hart, Richard L, Huganir   +2 more
openaire   +2 more sources