Results 1 to 10 of about 36,483 (183)

OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ mice [PDF]

Oncogenesis, 2014
Emerging evidence suggests that aberrant O-GlcNAcylation is associated with tumorigenesis. Many oncogenic factors are O-GlcNAcylated, which modulates their functions.
A Sveen, C Slawson, C Slawson, ER Fearon, GW Hart, GW Hart, HM Itkonen, JJ Smith, JR Ha, PG Suh, Q Zhu, R Sayat, S Olivier-Van Stichelen, SA Caldwell, T Kamigaito, TA Chan, TP Lynch, V Dehennaut, W Mi, W Rozanski, WH Yang, WY Mi, Y Gu, YR Yang, ZY Ma   +24 more
core   +6 more sources

Human O-GlcNAcase catalytic-stalk dimer anchors flexible histone binding domains [PDF]

Communications Chemistry
Although thousands of proteins are specifically O-GlcNAc modified, the molecular features recognized by the enzymes of O-GlcNAc cycling (OGT/OGA) remain poorly defined.
Sarah B. Nyenhuis, Agata Steenackers, Mana Mohan Mukherjee, Jenny E. Hinshaw, John A. Hanover   +4 more
doaj   +2 more sources

Synaptic toxicity of OGA inhibitors and the failure of ceperognastat. [PDF]

J Prev Alzheimers Dis
O-GlcNAcase inhibitors (OGAi) have emerged as a promising therapeutic strategy in Alzheimer's disease (AD) by enhancing O-GlcNAcylation, which competes with tau phosphorylation and reduces tau aggregation. However, the Phase II clinical trial failure of ceperognastat, marked by accelerated cognitive decline in the treatment group, has raised ...
Meade J, Mesa H, Alamgir S, Bieniecka I, Liu L, Zhang Q.   +5 more
europepmc   +6 more sources

OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair

Cell Death and Disease, 2021
Accumulated evidence shows that OGT-mediated O-GlcNAcylation plays an important role in response to DNA damage repair. However, it is unclear if the “eraser” O-GlcNAcase (OGA) participates in this cellular process.
Xiuhua Liu, Xiaochun Yu, Chen Wu
exaly   +2 more sources

NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation

Frontiers in Endocrinology, 2022
In vitro maturation (IVM) refers to the process of developing immature oocytes into the mature in vitro under the microenvironment analogous to follicle fluid.
Jiayu Lin, Yanyan Zeng, Taibao Wu
exaly   +3 more sources

Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex

Nature Communications, 2023
O-GlcNAcylation is a conserved post-translational modification that attaches N-acetyl glucosamine (GlcNAc) to myriad cellular proteins. In response to nutritional and hormonal signals, O-GlcNAcylation regulates diverse cellular processes by modulating ...
Ping Lu, Yusong Liu, Maozhou He
exaly   +2 more sources

Small molecule splicing modulators that disrupt O-GlcNAc homeostasis [PDF]

Nature Communications
O-Linked N-acetylglucosamine (O-GlcNAc) is a nucleocytoplasmic post-translational modification that is tightly regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).
Steven S. Cheng, Alison C. Mody, Amedeo Vetere, Ashwin Govindan, Yewon Lee, Danielle E. Khost, Rohan Narayan, Timothy B. Sackton, Nicholas K. Conrad, Bridget K. Wagner, Christina M. Woo   +10 more
doaj   +2 more sources

Artesunate inhibits hepatocellular carcinoma cell migration and invasion through OGA-mediated O-GlcNAcylation of ZEB1 [PDF]

Open Life Sciences
Artesunate combines with OGA, which promotes O-GlcNAcylation of ZEB1 and thus reduces the protein stability of ZEB1, further inhibiting migration and invasion of hepatocellular carcinoma cells.
Li Ying, Zhang Yuan, Lu Wei, Chen Yun, Qian Xiaoling   +4 more
doaj   +2 more sources

The relationship between social network addiction, online gaming addiction, and suicide ideation: mediating and moderating role of loneliness [PDF]

BMC Psychology
Digital addictions, specifically social network addiction (SNA) and online gaming addiction (OGA), are emerging as major public health issues, particularly due to their potential links with mental health risks.
Orhan Koçak, Ayşen Kovan, Abdulmohsen Mohammed Abdullah Alkhulayfi, Nouf Abdullah Alshehri, Merve Demirdöven, Murat Yıldırım   +5 more
doaj   +2 more sources

Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms [PDF]

Nature Communications
Nucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen, Sergio G. Bartual, Huijie Yuan, Olawale G. Raimi, Andrii Gorelik, Andrew T. Ferenbach, Kristian Lytje, Jan Skov Pedersen, Taner Drace, Thomas Boesen, Daan M. F. van Aalten   +10 more
doaj   +2 more sources