Results 11 to 20 of about 36,512 (211)

O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability

Cell Reports
Summary: Dysregulation of O-GlcNAcylation has emerged as a potential biomarker for several diseases, particularly cancer. The role of OGT (O-GlcNAc transferase) in maintaining O-GlcNAc homeostasis has been extensively studied; nevertheless, the ...
Won Ho Yang
exaly   +3 more sources

OGT and OGA gene-edited human induced pluripotent stem cells for dissecting the functional roles of O-GlcNAcylation in hematopoiesis

Frontiers in Cell and Developmental Biology
Hematopoiesis continues throughout life to produce all types of blood cells from hematopoietic stem cells (HSCs). Metabolic state is a known regulator of HSC self-renewal and differentiation, but whether and how metabolic sensor O-GlcNAcylation, which ...
Xing Kang, Pimonwan Srisook, Parinya Samart   +2 more
exaly   +3 more sources

Research on performance Evaluation method to promote sustainable development of opening government affairs [PDF]

E3S Web of Conferences, 2021
Open government affairs (OGA) play an important role in promoting national governance system and capacity. In order to realize an open and efficient government, it is necessary to scientifically evaluate the performance of government.
Zhou Mingle, Cao Shengli, Wang Ran, Wang Yu   +3 more
doaj   +1 more source

Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice

Journal of Integrative Neuroscience, 2023
Background: Tauopathies such as Alzheimer’s disease (AD) are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau (MAPT) aggregating into neurofibrillary tangles (NFTs).
Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbracht   +3 more
doaj   +1 more source

Short O-GlcNAcase Is Targeted to the Mitochondria and Regulates Mitochondrial Reactive Oxygen Species Level

Cells, 2022
O-GlcNAcylation is a reversible post-translational modification involved in the regulation of cytosolic, nuclear, and mitochondrial proteins. Only two enzymes, OGT (O-GlcNAc transferase) and OGA (O-GlcNAcase), control the attachment and removal of O ...
Patrick Pagesy, Abdelouhab Bouaboud, Zhihao Feng, Philippe Hulin, Tarik Issad   +4 more
doaj   +1 more source

Structural and functional insight into human O-GlcNAcase. [PDF]

, 2017
O-GlcNAc hydrolase (OGA) removes O-linked N-acetylglucosamine (O-GlcNAc) from a myriad of nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments, we determined the three-dimensional structure of human OGA, revealing an unusual ...
AJ McCoy, BL Cantarel, C Butkinaree, Christian Roth, CM Ferrer, David J Vocadlo, DJ Vocadlo, Dustin T King, E Krissinel, F Liu, FV Rao, G Winter, Gideon J Davies, Glyn R Hemsworth, GN Murshudov, JA Groves, K Cowtan, L Wells, Lianne I Willems, M Bergeron-Brlek, M Jínek, M Schimpl, MB Lazarus, MD Winn, MJ Fogg, MS Macauley, MZ Li, N Cekic, N Cetinbaş, O Lagerlöf, P Emsley, PD Adams, PR Evans, RJ Dennis, Robert Britton, S Hardivillé, S McNicholas, SA Yuzwa, Sherry Chan, SM Smith, T Izumi, VB Chen, Vimal Varghese, W Kabsch, Wendy A Offen, Y Gao, Y He   +46 more
core   +6 more sources

O-GlcNAcase contributes to cognitive function in Drosophila [PDF]

, 2020
Contains fulltext : 219183.pdf (publisher's version ) (Open ...
Catinozzi, Marica, Eidhof, Ilse, Fenckova, Michaela, Ferenbach, Andrew, Muha, Villo, Schenck, Annette, Storkebaum, Erik, van Aalten, Daan   +7 more
core   +3 more sources

Comparing Microsoft Kinect and Observational Gait Analysis in Assessing Gait Parameters of Apparently Healthy Adults [PDF]

Iranian Rehabilitation Journal, 2023
Objectives: Although the Microsoft Kinect has compelling potential for gait analysis in medicine, data available to compare it with observational gait analysis (OGA) is scarce.
Chidozie Emmanuel Mbada, Emmanuel Oluwatosin Abata, Omoniyi Ayokunle Ojapinwa, Saturday Nicholas Oghumu, Adekola Ademogoyegun, Francis Fatoye   +5 more
doaj  

O-GlcNAcase:promiscuous hexosaminidase or key regulator of O-GlcNAc signalling? [PDF]

, 2014
O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
Banerjee, Butkinaree, Cantarel, Cecioni, Cetinba, Comtesse, Copeland, Dennis, Dong, Dorfmueller, Dorfmueller, Drougat, Forsythe, Francisco, Gao, Gong, Graham, Guinez, Hanover, Hart, Hayakawa, He, He, Heckel, Hilgers, Housley, Howerton, Hu, Itkonen, Keembiyehetty, Knapp, Laczy, Lefebvre, Lepage, Libina, Liu, Macauley, Macauley, Macauley, Macauley, Macauley, Mahuran, Martin, Minami, Müller, Nagel, Olszewski, Ostrowski, Pathak, Penton, Radermacher, Rahman, Rao, Rao, Robinson, Ruan, Ruan, Schimpl, Schimpl, Schultz, Sekine, Shen, Slawson, Speakman, Stryke, Swallow, Tews, Toleman, Toleman, Torres, Wang, Wang, Webster, Wells, Whisenhunt, Whitworth, Yang, Yu, Yuzwa, Yuzwa, Zachara, Zachara, Zhu   +82 more
core   +3 more sources

One-Seventh of Patients with COVID-19 Had Olfactory and Gustatory Abnormalities as Their Initial Symptoms: A Systematic Review and Meta-Analysis

Life, 2020
Coronavirus disease 2019 (COVID-19) patients exhibited protean clinical manifestations. Olfactory and gustatory abnormalities (anosmia and ageusia) were observed in COVID-19 patients, but the reported prevalence varied.
Hsin Chi, Nan-Chang Chiu, Chun-Chih Peng, Chao-Hsu Lin, Yu-Lin Tai, Ming-Dar Lee, Yu-Jyun Cheng, Boon Fatt Tan, Chien-Yu Lin   +8 more
doaj   +1 more source