Results 21 to 30 of about 36,512 (211)

OGA inhibition by GlcNAc-selenazoline

Bioorganic & Medicinal Chemistry, 2010
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated ...
Kim, E. J., Love, D. C., Darout, E., Abdo, M., Rempel, B., Withers, S. G., Rablen, Paul R., Hanover, J. A., Knapp, S.   +8 more
openaire   +4 more sources

OGA-UCT: On-the-Go Abstractions in UCT

Proceedings of the International Conference on Automated Planning and Scheduling, 2016
Recent work has begun exploring the value of domain abstractions in Monte-Carlo Tree Search (MCTS) algorithms for probabilistic planning. These algorithms automatically aggregate symmetric search nodes (states or state-action pairs) saving valuable planning time.
Ankit Anand, Ritesh Noothigattu, Mausam, Parag Singla   +3 more
openaire   +2 more sources

Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors [PDF]

International Journal of Molecular Sciences, 2015
Abnormal phosphorylation of tau has been considered as a key pathogenic mechanism inducing tau aggregation in multiple neurodegenerative disorders, collectively called tauopathies. Recent evidence showed that tau phosphorylation sites are protected with O-linked β-N-acetylglucosamine (O-GlcNAc) in normal brain.
Sungsu Lim, Md. Haque, Ghilsoo Nam, Nayeon Ryoo, Hyewhon Rhim, Yun Kim   +5 more
openaire   +3 more sources

Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice

Diabetes & Vascular Disease Research, 2023
Sustained hyperglycemia results in excess protein O -GlcNAcylation, leading to vascular complications in diabetes. This study aims to investigate the role of O -GlcNAcylation in the progression of coronary microvascular disease (CMD) in inducible type 2 ...
Jody Tori Cabrera, Rui Si, Atsumi Tsuji-Hosokawa, Hua Cai, Jason X-J Yuan, Wolfgang H Dillmann, Ayako Makino   +6 more
doaj   +1 more source

OGA: an ontological tool of human phenotypes with genetic associations [PDF]

BMC Research Notes, 2013
Background: The availability of genetic data has increased dramatically in recent years. The greatest value of this data is its potential for personalized medicine. Many new associations are reported every day from Genome Wide Association Studies (GWAS). However, robust, reproducible associations are elusive for some complex diseases.
Herrera-Galeano, Jesus, Hirschberg, David L., Mokashi, Vishwesh, Solka, Jeffrey   +3 more
openaire   +3 more sources

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry [PDF]

, 2018
The attachment of the sugar N-acetyl-D-glucosamine (GlcNAc) to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation.
Aristotelous, Tonia, Borodkin, Vladimir S., Ferenbach, Andrew T., Navratilova, Iva, Rafie, Karim, Selvan, Nithya, Van Aalten, Daan M.F.   +6 more
core   +3 more sources

O-GlcNAcase expression is sensitive to changes in O-GlcNAc homeostasis

Frontiers in Endocrinology, 2014
O-linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification involving an attachment of a single β-N-acetylglucosamine moiety to serine or threonine residues in nuclear and cytoplasmic proteins.
ZHEN eZHANG, Ee Phie eTan, Nicole eVandenHull, Kenneth R. Peterson, Chad eSlawson   +4 more
doaj   +1 more source

O-GlcNAcylation regulates extracellular signal-regulated kinase (ERK) activation in Alzheimer’s disease

Frontiers in Aging Neuroscience, 2023
IntroductionAberrant activation of Extracellular Signal-Regulated Kinase (ERK) signaling is associated with Alzheimer’s disease (AD) pathogenesis. For example, enhanced ERK signal activation mediated by Apolipoprotein E4 (APOE4), which is a critical ...
Sophiya John Ephrame, Gentry K. Cork, Victoria Marshall, Margaret A. Johnston, Jenna Shawa, Ibtihal Alghusen, Amy Qiang, Aspin R. Denson, Marisa S. Carman, Halyna Fedosyuk, Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Chad Slawson, Chad Slawson   +14 more
doaj   +1 more source

Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation [PDF]

, 2017
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O ...
AL Mammen, AT Huddleston, BD Lazarus, BQ Liu, C Betzen, C Kim, CS Arnold, DJ Whitcomb, E Benito, EW Taylor, F Liu, GA Ngoh, GW Hart, HJ Goldberg, HK Lee, J Boehm, J Jo, J Lisman, JE Rexach, JF Alfaro, JH Morrison, JR Erickson, K Liu, K Vosseller, KW Roche, L Gong, LS Griffith, LS Griffith, LT Knapp, M Ogawa, M Robles-Flores, M Tiedge, MK Tallent, MP Housley, NP Marotta, R Okuyama, RJ Konrad, RL Huganir, RN Cole, RN Cole, SA Yuzwa, SN Burke, T Hosokawa, T Kanno, WB Dias, Y Akimoto, Y Skorobogatko, YR Yang, YR Yang, YR Yang, YR Yang, Z Wang   +51 more
core   +1 more source

Targeting tau for Alzheimers disease through OGA inhibition. [PDF]

J Prev Alzheimers Dis
Rafii MS.
europepmc   +3 more sources