Results 51 to 60 of about 20,888 (214)

O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Protein posttranslational modifications by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood.
Wei‐Zhong Zhu, Danny El‐Nachef, Xiulan Yang, Dolena Ledee, Aaron K. Olson   +4 more
doaj   +1 more source

Functional Analysis of O-GlcNAcylation in Cancer Metastasis

Frontiers in Oncology, 2020
One common and reversible type of post-translational modification (PTM) is the addition of O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), and its dynamic balance is controlled by O-GlcNAc transferase (OGT) and glycoside ...
Donglu Wu, Donglu Wu, Jingji Jin, Zhidong Qiu, Zhidong Qiu, Da Liu, Da Liu, Haoming Luo, Haoming Luo   +8 more
doaj   +1 more source

Age-related elevation of O-GlcNAc causes meiotic arrest in male mice

Cell Death Discovery, 2023
In recent years, the postponement of childbearing has become a critical social issue. Male fertility is negatively associated with age because of testis aging. Spermatogenesis is impaired with age, but the molecular mechanism remains unknown. The dynamic
Zhang Qian, Chuwei Li, Shanmeizi Zhao, Hong Zhang, Rujun Ma, Xie Ge, Jun Jing, Li Chen, Jinzhao Ma, Yang Yang, Lu Zheng, Kemei Zhang, Zhaowanyue He, Mengqi Xue, Ying Lin, Kadiliya Jueraitetibaike, Yuming Feng, Chun Cao, Ting Tang, Shanshan Sun, Hui Teng, Wei Zhao, Bing Yao   +22 more
doaj   +1 more source

An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]

, 2003
The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B., Knopf, Lea G., Li, Yajie, Marti, Matthias, Müller, Norbert, Regös, Attila, Schraner, Elisabeth M., Wild, Peter   +7 more
core   +1 more source

Distribution of O-GlcNAc Transferase in the Rat Pancreas.

ACTA HISTOCHEMICA ET CYTOCHEMICA, 2000
O−GlcNAc transferase(OGT) catalyzes the attachment of N−acetylglucosamine monosaccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway. We examined the localization of OGT protein in the rat pancreas.
Yoshihiro Akimoto, Gerald W. Hart, Hiroshi Hirano   +2 more
openaire   +2 more sources

O-GlcNAc: A Sweetheart of the Cell Cycle and DNA Damage Response

Frontiers in Endocrinology, 2018
The addition and removal of O-linked N-acetylglucosamine (O-GlcNAc) to and from the Ser and Thr residues of proteins is an emerging post-translational modification.
Caifei Liu, Jing Li
doaj   +1 more source

O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Molecular Medicine, 2022
O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all animals and plants.
Qingsong Lu, Xiaozhen Zhang, Tingbo Liang, Xueli Bai   +3 more
doaj   +1 more source

A structural and biochemical model of processive chitin synthesis [PDF]

, 2014
Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Andrew T. Ferenbach, Atkinson, Barny, Bond, Bowen, Cabib, Charnock, Coutinho, D'Haeze, Daan M.F. van Aalten, Debellé, Drew, Gaughran, Helge C. Dorfmueller, Imai, Kamst, Kamst, Kamst, Karnezis, Kathiravan, Källberg, Manoil, Martínez-Rucobo, Masubuchi, Mavingui, Morgan, Nagahashi, Orlean, Rao, Ruiz-Herrera, Semino, Shaw, Streng, Sudoh, Thompson, Uchida, Vladimir S. Borodkin, Xie, Yabe   +38 more
core   +3 more sources

O‐GlcNAc Transferase is a Critical Regulator of Cytokinesis

The FASEB Journal, 2006
O‐GlcNAc is a ubiquitous and dynamic post‐translational protein modification consisting of a single N‐acetylglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Previous work in our laboratory has shown that elevated O‐GlcNAc levels either though pharmacological or genetic manipulation leads to delays in cell ...
Chad Slawson, Gerald W. Hart
openaire   +1 more source

Substrate and product analogues as human O-GlcNAc transferase inhibitors [PDF]

Amino Acids, 2010
Protein glycosylation on serine/threonine residues with N-acetylglucosamine (O-GlcNAc) is a dynamic, inducible and abundant post-translational modification. It is thought to regulate many cellular processes and there are examples of interplay between O-GlcNAc and protein phosphorylation. In metazoa, a single, highly conserved and essential gene encodes
Dorfmueller, Helge C., Borodkin, Vladimir S., Blair, David E., Pathak, Shalini, Navratilova, Iva, van Aalten, Daan M. F.   +5 more
openaire   +3 more sources