Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics [PDF]
, 2007 The addition of the monosaccharide beta-N-acetyl-D-glucosamine to proteins (O-GlcNAc glycosylation) is an intracellular, post-translational modification that shares features with phosphorylation.
Bryan, Marian C. +9 more
core +1 more source
Structural and functional insight into human O-GlcNAcase [PDF]
, 2017 O-GlcNAc hydrolase (OGA) removes O-linked N-acetylglucosamine (O-GlcNAc) from a myriad of nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments, we determined the three-dimensional structure of human OGA, revealing an unusual ...
Roth, Christian +9 more
core +6 more sources
Phosphorylation modification of wheat lectin VER2 is associated with vernalization-induced O-GlcNAc signaling and intracellular motility. [PDF]
PLoS ONE, 2009 BACKGROUND: O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins mediates stress response and cellular motility in animal cells. The plant lectin concanavalin A can increase nuclear O-GlcNAc levels and decrease cytoplasmic O-GlcNAc ...
Lijing Xing +4 more
doaj +1 more source
BMJ Open Diabetes Research & Care, 2021 Introduction This study aims to determine whether high glucose condition and dynamic O-linked N-acetylglucosamine (O-GlcNAc) modification can promote the proliferation and migration of human retinal microvascular endothelial cells (HRMECs) and whether ...
Yan Jiang +5 more
doaj +1 more source
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. [PDF]
, 2019 Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of ...
Albarran, Eddy +8 more
core +1 more source
New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
Frontiers in Chemistry, 2021 O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins ...
Matjaž Weiss +9 more
doaj +1 more source
O-GlcNAcase:promiscuous hexosaminidase or key regulator of O-GlcNAc signalling? [PDF]
, 2014 O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
Banerjee +82 more
core +3 more sources
Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation [PDF]
, 2003 We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain.
Hsieh-Wilson, Linda C. +1 more
core +1 more source
A nexus of lipid and O-Glcnac metabolism in physiology and disease
Frontiers in Endocrinology, 2022 Although traditionally considered a glucose metabolism-associated modification, the O-linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids and is required to maintain lipid homeostasis.
Amber Lockridge, John A. Hanover
doaj +1 more source
Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags [PDF]
, 2010 Mechanistic studies of O-GlcNAc glycosylation have been limited by an inability to monitor the glycosylation stoichiometries of proteins obtained from cells.
Hsieh-Wilson, Linda C. +5 more
core +2 more sources