OGT restrains the expansion of DNA damage signaling [PDF]
Nucleic Acids Research, 2016 O-linked N-acetylglucosamine linkage (O-GlcNAcylation) to serine or threonine residues regulates numerous biological processes; however, its role in DNA damage response remains elusive. Here, we found that O-GlcNAcylation is induced by DNA damage response.
Chen, Qiang, Yu, Xiaochun
openaire +2 more sources
O-GlcNAcase contributes to cognitive function in Drosophila [PDF]
, 2020 Contains fulltext : 219183.pdf (publisher's version ) (Open ...
Catinozzi, Marica +7 more
core +3 more sources
Optimization of an in vitro transcription/translation system based on Sulfolobus solfataricus cell lysate. [PDF]
, 2018 A system is described which permits the efficient synthesis of proteins in vitro at high temperature. It is based on the use of an unfractionated cell lysate (S30) from Sulfolobus solfataricus previously well characterized in our laboratory for ...
Anna La Teana, +5 more
core +2 more sources
An in-silico analysis of OGT gene association with diabetes mellitus
BMC Research Notes, 2023 Abstract O-GlcNAcylation is a nutrient-sensing post-translational modification process. This cycling process involves two primary proteins: the O-linked N-acetylglucosamine transferase ( OGT ) catalysing the addition, and the glycoside hydrolase OGA (O-GlcNAcase) catalysing ...
Ayodele, Abigail O. +8 more
openaire +4 more sources
The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix [PDF]
, 2018 O-linked β-N-acetyl-D-glucosamine (O-GlcNAc) transferase (OGT) regulates protein O-GlcNAcylation, an essential post-translational modification that is abundant in the brain.
Abraham +41 more
core +2 more sources
Biology, 2022 Acute pancreatitis (AP) involves premature trypsinogen activation, which mediates a cascade of pro-inflammatory signaling that causes early stages of pancreatic injury.
Mackenzie Moore +5 more
doaj +1 more source
Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray. [PDF]
PLoS ONE, 2016 O-GlcNAcylation is a reversible and dynamic protein post-translational modification in mammalian cells. The O-GlcNAc cycle is catalyzed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).
Jie Shi +3 more
doaj +1 more source
Operator Gauge Symmetry in QED [PDF]
, 2006 In this paper, operator gauge transformation, first introduced by Kobe, is applied to Maxwell's equations and continuity equation in QED. The gauge invariance is satisfied after quantization of electromagnetic fields.
Khademi, Siamak, Nasiri, Sadollah
core +2 more sources
The inhibitory effects of Orengedokuto on inducible PGE2 production in BV-2 microglial cells
Heliyon, 2021 Background and aim: Reactive microglia has been associated with neuroinflammation caused by the production of proinflammatory molecules such as cytokines, nitric oxide, and prostaglandins. The overexpression of these molecules may provoke neuronal damage
Yoshika Iwata +6 more
doaj +1 more source
Impact of OGT deregulation on EZH2 target genes FOXA1 and FOXC1 expression in breast cancer cells. [PDF]
PLoS ONE, 2018 Enhancer of zest homolog 2 (EZH2) is a histone methyltransferase which plays a crucial role in cancer progression by regulation of genes involved in cellular processes such as proliferation, invasion and self-renewal.
Ewa Forma +6 more
doaj +1 more source