Results 11 to 20 of about 22,588 (217)
Cell Death and DiseaseO-GlcNAcylation catalyzed by O-GlcNAc transferase (OGT) plays an important role in the regulation of tumor glycolysis. However, the mechanism underlying OGT regulation remains largely unknown.
Luyao Lin +11 more
doaj +3 more sources
Genes to Cells, 2013 Gene expression is controlled by alterations in the epigenome, including DNA methylation and histone modification. Recently, it was reported that 5‐methylcytosine (5mC) is converted to 5‐hydroxymethylcytosine (5hmC) by proteins in the ten‐eleven translocation (TET) family.
Ryo, Ito +7 more
openaire +2 more sources
Activation by NarL at the Escherichia coli ogt promoter [PDF]
Biochemical Journal, 2020 The Escherichia coli NarX/NarL two-component response-regulator system regulates gene expression in response to nitrate ions and the NarL protein is a global transcription factor, which activates transcript initiation at many target promoters. One such target, the E.
Patcharawarin Ruanto +6 more
openaire +4 more sources
Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights [PDF]
International Journal of Molecular Sciences, 2017 O6-DNA-alkyl-guanine-DNA-alkyl-transferases (OGTs) are evolutionarily conserved, unique proteins that repair alkylation lesions in DNA in a single step reaction. Alkylating agents are environmental pollutants as well as by-products of cellular reactions, but are also very effective chemotherapeutic drugs.
Riccardo Miggiano +5 more
openaire +5 more sources
PLoS Genetics, 2020 The conserved O-GlcNAc transferase OGT O-GlcNAcylates serine and threonine residues of intracellular proteins to regulate their function. OGT is required for viability in mammalian cells, but its specific roles in cellular physiology are poorly ...
Sarel J Urso +3 more
doaj +1 more source
Specificity of oligonucleotide gene therapy (OGT) agents
Theranostics, 2022 Oligonucleotide gene therapy (OGT) agents (e. g. antisense, deoxyribozymes, siRNA and CRISPR/Cas) are promising therapeutic tools. Despite extensive efforts, only few OGT drugs have been approved for clinical use. Besides the problem of efficient delivery to targeted cells, hybridization specificity is a potential limitation of OGT agents.
Nedorezova, Daria D. +5 more
openaire +2 more sources
A Small Molecule That Inhibits OGT Activity in Cells [PDF]
ACS Chemical Biology, 2015 O-GlcNAc transferase (OGT) is an essential mammalian enzyme that regulates numerous cellular processes through the attachment of O-linked N-acetylglucosamine (O-GlcNAc) residues to nuclear and cytoplasmic proteins. Its targets include kinases, phosphatases, transcription factors, histones, and many other intracellular proteins.
Rodrigo F, Ortiz-Meoz +9 more
openaire +2 more sources
Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex
Nature Communications, 2023 O-GlcNAcylation is a conserved post-translational modification that attaches N-acetyl glucosamine (GlcNAc) to myriad cellular proteins. In response to nutritional and hormonal signals, O-GlcNAcylation regulates diverse cellular processes by modulating ...
Ping Lu +7 more
doaj +1 more source
Frontiers in Physiology, 2020 Background and Aims: Increased O-GlcNAc transferase (OGT)–induced O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification is linked with diabetic complications.
Wan-Yu Lo +4 more
doaj +1 more source
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. [PDF]
, 2019 Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of ...
Albarran, Eddy +8 more
core +1 more source