Results 41 to 50 of about 22,588 (217)

How the glycosyltransferase OGT catalyzes amide bond cleavage [PDF]

Nature Chemical Biology, 2016
The essential human enzyme O-linked β-N-acetylglucosamine transferase (OGT), known for modulating the functions of nuclear and cytoplasmic proteins through serine and threonine glycosylation, was unexpectedly implicated in the proteolytic maturation of the cell cycle regulator host cell factor-1 (HCF-1).
Janetzko, John, Trauger, Sunia, Lazarus, Michael B., Walker, Suzanne   +3 more
openaire   +3 more sources

O-GlcNAc modification in endothelial cells modulates adiposity via fat absorption from the intestine in mice

Heliyon
Introduction: Endothelial cells have a crucial function in transporting and exchanging various nutrients. O-GlcNAcylation, mediated by O-GlcNAc transferase (OGT), involves the addition of N-acetylglucosamine to proteins and serves as an intracellular ...
Seiichiro Ohgaku, Shogo Ida, Natsuko Ohashi, Katsutaro Morino, Atsushi Ishikado, Tsuyoshi Yanagimachi, Koichiro Murata, Daisuke Sato, Satoshi Ugi, Ali Nasiri, Gerald I. Shulman, Hiroshi Maegawa, Shinji Kume, Yukihiro Fujita   +13 more
doaj   +1 more source

OGT and OGA: Sweet guardians of the genome

Journal of Biological Chemistry
The past 4 decades have witnessed tremendous efforts in deciphering the role of O-GlcNAcylation in a plethora of biological processes. Chemists and biologists have joined hand in hand in the sweet adventure to unravel this unique and universal yet uncharted post-translational modification, and the recent advent of cutting-edge chemical biology and mass
Chen Wu, Jiaheng Li, Lingzi Lu, Mengyuan Li, Yanqiu Yuan, Jing Li   +5 more
openaire   +2 more sources

Cardiomyocyte Ogt is essential for postnatal viability

American Journal of Physiology-Heart and Circulatory Physiology, 2014
The singly coded gene O-linked-β- N-acetylglucosamine ( O-GlcNAc) transferase ( Ogt) resides on the X chromosome and is necessary for embryonic stem cell viability during embryogenesis. In mature cells, this enzyme catalyzes the posttranslational modification known as O-GlcNAc to various cellular proteins. Several groups, including our own, have shown
Lewis J, Watson, Bethany W, Long, Angelica M, DeMartino, Kenneth R, Brittian, Ryan D, Readnower, Robert E, Brainard, Timothy D, Cummins, Lakshmanan, Annamalai, Bradford G, Hill, Steven P, Jones   +9 more
openaire   +3 more sources

SIRT1 regulates O-GlcNAcylation of tau through OGT

Aging, 2020
Tau is modified with O-GlcNAcylation extensively in human brain. The O-GlcNAcylation levels of tau are decreased in Alzheimer's disease (AD) brain. Sirtuin type 1 (SIRT1) is an enzyme that deacetylates proteins including transcriptional factors and associates with neurodegenerative diseases, such as AD.
Lu, Shu, Yin, Xiaomin, Wang, Jia, Gu, Qun, Huang, Qin, Jin, Nana, Chu, Dandan, Xu, Ziqi, Liu, Fei, Qian, Wei   +9 more
openaire   +2 more sources

MicroRNA-200a/200b Modulate High Glucose-Induced Endothelial Inflammation by Targeting O-linked N-Acetylglucosamine Transferase Expression

Frontiers in Physiology, 2018
Background and Aims: Increased O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins by O-GlcNAc transferase (OGT) is associated with diabetic complications. Furthermore, oxidative stress promotes endothelial inflammation during diabetes.
Wan-Yu Lo, Wan-Yu Lo, Wen-Kai Yang, Wen-Kai Yang, Ching-Tien Peng, Wan-Yu Pai, Huang-Joe Wang, Huang-Joe Wang   +7 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Two-neutrino double electron capture on $^{124}$Xe based on an effective theory and the nuclear shell model

, 2018
We study the two-neutrino double electron capture on $^{124}$Xe based on an effective theory (ET) and large-scale shell model calculations, two modern nuclear structure approaches that have been tested against Gamow-Teller and double-beta decay data.
Menéndez, J., Pérez, E. A. Coello, Schwenk, A.   +2 more
core   +1 more source

Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors [PDF]

, 2018
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors.
Andrii Gorelik, Bogachev V. S., Daan M. F. van Aalten, Derossi D., Dong D. L., Karim Rafie, Riccardo Trapannone, Torres C. R., Vladimir S. Borodkin   +8 more
core   +3 more sources

Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice [PDF]

, 2020
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on ...
Claro Cala, Carmen María, Herrera González, María Dolores, Miñano Sánchez, Francisco Javier, Pérez Montero , Marta, Quintela, José Carlos, Rodríguez Rodríguez , Rosalía, Álvarez de Sotomayor Paz, María   +6 more
core   +1 more source