Results 61 to 70 of about 22,588 (217)

A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization

Frontiers in Immunology, 2023
IntroductionO-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA).
Xiaozhi Xi, Xiaozhi Xi, Xiaozhi Xi, Guokai Xiao, Guokai Xiao, Guokai Xiao, Guiqi An, Lin Liu, Xiaochun Liu, Peiyu Hao, Peiyu Hao, Peiyu Hao, Jennifer Yiyang Wang, Dandan Song, Dandan Song, Dandan Song, Wengong Yu, Wengong Yu, Wengong Yu, Yuchao Gu, Yuchao Gu, Yuchao Gu   +21 more
doaj   +1 more source

DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection [PDF]

, 2010
Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response.
Adams, Afanasev, Alina E. Gorna, Aly, Arnold, Bacon, Banu, Bergval, Betts, Boshoff, Boshoff, Bostanabad, Burney, Capelli, Chan, Chan, Cheng, Cooper, Cubillos-Ruiz, Darwin, Darwin, Das, Davis, Dos Vultos, Dubnau, Durbach, Farnia, Fennelly, Filliol, Fleischmann, Flint, Fontan, Friedberg, Frischkorn, Fu, Fu, Gaynor, Gordhan, Graham, Grishko, Guthlein, Hampshire, Hazbon, Hughes, Jain, Jaroslaw Dziadek, Jiao, Kapur, Karakousis, Karakousis, Karunkaran, Katti, Kesavan, Kim, Ko, Ko, Korycka-Machala, Krokan, Kurthkoti, Kurthkoti, Lari, Lever, Loudon, MacMicking, Malshetty, Martinez, Mokrousov, Moller, Movahedzadeh, Mulder, Munoz-Elias, Muttucumaru, Nguyen, Niemann, Nikolayevskyy, Nouvel, O'sullivan, Olano, Peccia, Peccia, Pitcher, Rachman, Rachman, Rad, Ramaswamy, Richard P. Bowater, Riley, Saito, Sander, Sassetti, Sassetti, Saunders, Schnappinger, Schwab, Sherman, Sinha, Sinha, Smeulders, Springer, Srivastava, Stephanou, Talaat, Talaat, Tang, Tsai, Venkatesh, Vilcheze, Voskuil, Voskuil, Waddell, Wanner, Warner, Weikert, Wiid, Wiseman, World Health Organization, Zaczek, Zainuddin   +117 more
core   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Augmented Reality of Anatomical Structures of the Maxillomandibular Complex for Learning Dental Radiographic Techniques

Journal of Dental Education, EarlyView.
ABSTRACT Introduction Augmented reality (AR) enables interactive learning in real‐world environments. In dental radiography education, AR offers a promising tool to enhance students' clinical skills by allowing them to simulate and practice procedures before engaging with actual patients. Repeated practice in an AR environment can reinforce theoretical
Maitê Michel Piazza Willig, Mariana Boessio Vizzotto, Henrique Timm Vieira, Priscila Fernanda da Silveira Tiecher, Thiago de Oliveira Gamba, Nádia Assein Arús, Luis Ernesto Arriola‐Guillén, Heraldo Luís Dias da Silveira   +7 more
wiley   +1 more source

Mapping Patient Complexity to Educational Needs: Proof‐of‐Concept for a Data‐Driven Framework

Journal of Dental Education, EarlyView.
ABSTRACT Purpose: This study aimed to determine whether routinely collected clinical data from a university dental clinic could be translated into a coherent framework for organizing competency‐based clinical training. By examining patterns of patient complexity, the study sought to generate an evidence‐informed set of educational care lines to guide ...
Francesca Zotti, Rozendo Luiz Corso, Bruna Orlandin, Leandro Corso, Thiago Oliveira Gamba   +4 more
wiley   +1 more source

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]

, 2015
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R, Arnold, Don B, Langen, Ralf, Lewis, Yuka E, Lin, Yu Hsuan, Marotta, Nicholas P, Pratt, Matthew R, Roth, Maxwell T, Zaro, Balyn W   +8 more
core   +2 more sources

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

Tracking the Pulse of the Dunes: Seasonal Metabolic Responses of Liolaemus arambarensis to Climatic Variability

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Seasonal environmental fluctuations profoundly influence ectothermic vertebrates, regulating their physiology, metabolism, and life cycles. This study investigated the metabolic and morphometric seasonal dynamics of the subtropical sand lizard Liolaemus arambarensis, an endangered species endemic to the coastal dunes of southern Brazil.
Artur Antunes Navarro Valgas, Gustavo Kasper Cubas, Diogo Reis de Oliveira, Jessica Fonseca Araujo, Guendalina Turcato Oliveira, Laura Verrastro   +5 more
wiley   +1 more source

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

eLife
The O-GlcNAc transferase (OGT) is an essential enzyme that mediates protein O-GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins.
Jianwen Chen, Bao Zhao, Hong Dong, Tianliang Li, Xiang Cheng, Wang Gong, Jing Wang, Junran Zhang, Gang Xin, Yanbao Yu, Yu L Lei, Jennifer D Black, Zihai Li, Haitao Wen   +13 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source