Results 71 to 80 of about 22,588 (217)
BMC Cardiovascular DisordersBackground The O-GlcNAc transferase (OGT) levels are closely related to the O-GlcNAcylation of proteins and are also associated with cardiovascular disease. This study explored the association between OGT activity and major adverse cardiovascular events (
Wei Yu +5 more
doaj +1 more source
Biased amino acid composition in warm-blooded animals [PDF]
, 2009 Among eubacteria and archeabacteria, amino acid composition is correlated with habitat temperatures. In particular, species living at high temperatures have proteins enriched in the amino acids E-R-K and depleted in D-N-Q-T-S-H-A. Here, we show that this
Guang-Zhong Wang, Martin J. Lercher
core +1 more source
, 2016 We study actions of Lie supergroups, in particular, the hitherto elusive notion of orbits through odd (or more general) points. Following categorical principles, we derive a conceptual framework for their treatment and therein prove general existence ...
Alldridge, Alexander +2 more
core +2 more sources
Cancer Science, EarlyView.Lysine acetyltransferase 2A (KAT2A) is a transcriptional coactivator and a member of the Histone Acetyltransferase (HAT) family. While altered KAT2A activity has been implicated in various cancers, its role in bladder cancer (BLCA) remains poorly understood.
Wenjie Yang +8 more
wiley +1 more source
O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury
Brain Research BulletinBackground: Spinal cord injury (SCI) represents a severe disorder of the nervous system, imposing significant physical, psychological, and socioeconomic burdens on affected individuals and society. Objective: We investigated the implication of O-linked β-
Zhichao Zeng, Xuqiang Liao, Xinjian Zhao
doaj +1 more source
Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids [PDF]
MedChemComm, 2018 O-GlcNAc transferase (OGT) attaches a GlcNAc moiety on specific substrate proteins using UDP-GlcNAc as the sugar donor.
Hao Zhang +6 more
openaire +3 more sources
The Journal of Clinical Investigation, 2023 Major depressive disorder is a common and devastating psychiatric disease, and the prevalence and burden are substantially increasing worldwide. Multiple studies of depression patients have implicated glucose metabolic dysfunction in the pathophysiology ...
Jun Fan +16 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu +7 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1286-1305, June 2026.ABSTRACT Bladder exstrophy and epispadias complex (BEEC) is one of the most severe congenital malformations of the urogenital tract, significantly impacting continence, sexual function, and renal function. To date, the only recurrent genetic aberration identified is the 22q.11.2 microduplication, but several candidate regions and genes including ...
Agneta Nordenskjöld +9 more
wiley +1 more source
O-GlcNAc transferase acts as a critical nutritional node for the control of liver homeostasis
JHEP ReportsBackground & Aims: O-GlcNAcylation is a reversible post-translational modification controlled by the activity of two enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).
Paula Ortega-Prieto +16 more
doaj +1 more source