Results 91 to 100 of about 22,588 (217)

Can O-GIcNAc Transferase (OGT) Complex Be Used as a Target for the Treatment of Hematological Malignancies?

Pharmaceuticals
The circulatory system is a closed conduit system throughout the body and consists of two parts as follows: the cardiovascular system and the lymphatic system.
Shiwei Zhuang, Zhimei Liu, Jinyao Wu, Yudan Yao, Zongyang Li, Yanxiang Shen, Bin Yu, Donglu Wu   +7 more
doaj   +1 more source

Secure & Prepared, January 10, 2007, Vol.3, no.1 [PDF]

, 2007
Secure & Prepared is a bi-weekly publication of the Iowa Homeland Security & Emergency Management Division for those involved in the homeland security system in the state of ...

core  

Quenching of Weak Interactions in Nucleon Matter [PDF]

, 2002
We have calculated the one-body Fermi and Gamow-Teller charge-current, and vector and axial-vector neutral-current nuclear matrix elements in nucleon matter at densities of 0.08, 0.16 and 0.24 fm$^{-3}$ and proton fractions ranging from 0.2 to 0.5.
A. Akmal, A. Arima, A. Fabrocini, A.C. Hayes, B.S. Pudliner, E. Kolbe, G. Martinez-Pinedo, I. Bombaci, I.E. Lagaris, J. Morales, J.G. Congleton, J.L. Forest, J.W. Clark, K. Langanke, K. Suzuki, L.B. Auerbach, L.E. Marcucci, M. Prakash, M. Sakuda, P. Navratil, Q.R. Ahmad, R. Schiavilla, R. Schiavilla, R.B. Wiringa, S. Cowell, S. Fantoni, S. Fantoni, S. Fantoni, S. Fantoni, S. Fantoni, S. Reddy, S.C. Pieper, T.T.S. Kuo, V. R. Pandharipande, V.R. Pandharipande, V.R. Pandharipande   +35 more
core   +1 more source

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh, Richard Miallot, Chelsea De Bellis, Philippe Jolivet, Joanna Przybyl   +4 more
wiley   +1 more source

Pharmacological Inhibition of O-GlcNAc Transferase Promotes mTOR-Dependent Autophagy in Rat Cortical Neurons

Brain Sciences, 2020
O-GlcNAc transferase (OGT) is a ubiquitous enzyme that regulates the addition of β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of target proteins. Autophagy is a cellular process of self-digestion, in which cytoplasmic resources, such
Md. Ataur Rahman, Yoonjeong Cho, Hongik Hwang, Hyewhon Rhim   +3 more
doaj   +1 more source

Liver Stiffness Characterization of OGTLKO Mouse Model of Progressive Liver Fibrosis

Journal of Ultrasound in Medicine, Volume 45, Issue 5, Page 1069-1082, May 2026.
Objectives O‐GlcNAcylation plays a key regulatory role in hepatic physiology, and its disruption leads to fibrosis in liver‐specific OGT knockout mice (OGTLKO), making this model valuable for studying advanced metabolic dysfunction‐associated steatohepatitis (MASH).
Gilles Renault, Lenin Chinchilla, Lourdes Massengo, Pierre Monbernard, Fadila Benhamed, Marion Regnier, Raphael Denis, Catherine Postic, Anthony Novell, Jean‐Luc Gennisson   +9 more
wiley   +1 more source

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins [PDF]

, 2016
O-linked N-acetylglucosamine modification (O-GlcNAcylation) is a nutrient-dependent protein post-translational modification (PTM), dynamically and reversibly driven by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) that catalyse the ...
Akimoto, Andrew T. Ferenbach, Banerjee, Butkinaree, Cao, Comer, Corrado, Daan M.F. van Aalten, Daniel Mariappa, Dassanayaka, Dias, Dong, Exner, Frezza, Gawlowski, Gu, Haltiwanger, Haltiwanger, Hanover, Hanover, Hart, Hart, Hofer, Housley, Hu, Hube, Iyer, Iyer, Johnsen, Kreppel, Lazarus, Lazarus, Liu, Love, Love, Lozano, Ma, Ma, Nolte, Olichon, Pathak, Pekkurnaz, Riccardo Trapannone, Ruan, Shafi, Shin, Sohn, Tan, Torres, van den Ent, Walgren, Wang, Yang, Yi, Zhao, Zhou, Zhu   +56 more
core   +3 more sources

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis

Journal of Orthopaedic Translation
Background: O-GlcNAc transferase (OGT) is responsible for attaching O-linked N-acetylglucosamine (O-GlcNAc) to proteins, regulating diverse cellular processes ranging from transcription and translation to signaling and metabolism.
Yu Du, Xiang Gao, Jianqiang Chen, Xinxin Chen, Hang Liu, Wenge He, Lu Liu, Yue Jiang, Baicheng He, Zhongliang Deng, Chao Liang, Fengjin Guo   +11 more
doaj   +1 more source

Improving Detection of Prediabetes in Children and Adults: Using Combinations of Blood Glucose Tests

Frontiers in Public Health, 2015
Aim: To determine combinations of blood glucose tests: oral glucose tolerance (OGT), fasting plasma glucose (FBG) and hemoglobin A1C (HbA1C) that are associated with highest diagnostic rates of prediabetes in non-diabetic American children and adults ...
Ike Solomon Okosun, J Paul Seale, Rodney eLyn, Monique eDavis-Smith   +3 more
doaj   +1 more source