Results 111 to 120 of about 22,588 (217)

HCF-1 as a key modulator of OGT function and O-GlcNAcylation in the liver

Scientific Reports
Host cell factor-1 (HCF-1) is a transcriptional coregulator essential for maintaining liver function and cellular metabolism. O-linked N-acetylglucosamine transferase (OGT) is a key nutrient-sensing enzyme that catalyzes protein O-GlcNAcylation, a ...
Vaibhav Kapuria, Ayushma, Winship Herr, Shilpi Minocha   +3 more
doaj   +1 more source

407 The OGT/O-GlcNAc Axis Regulates Fibrosis Resolution in Idiopathic Pulmonary Fibrosis

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by dysregulated collagen accumulation in the lung parenchyma.
Shia Vang, Yiming Livelo, Bailey Burpee, Meghan J. Hirsch, Emma L. Matthews, Luke I. Jones, Girish Melkani, Stefanie Krick, Jarrod W. Barnes   +8 more
doaj   +1 more source

USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT

Cancer Cell International
Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development. Herein, we identified Ubiquitin-specific peptidase 8 (USP8) as a key regulator for promoting the tumorigenesis of iCCA cell via stabilizing OGT ...
Guo Long, Dong Wang, Jianing Tang, Kuan Hu, Ledu Zhou   +4 more
doaj   +1 more source

GENUS : a generic component library for high level synthesis [PDF]

, 1988
This report describes the organization of GENUS, a generic component library for high level synthesis. Generic components and instances in GENUS are organized into hierarchical classes, with the component type stored at the root of the hierarchy, and ...
Dutt, Nikil D.
core  

High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell

Autoimmunity
Objective O-linked N-acetylglucosamine (O-GlcNAc) glycosylation represents a prevalent post-translational modification of proteins. Accumulating evidence indicates that dysregulated O-GlcNAcylation can induce glucose toxicity and plays critical roles in ...
Jing Qin, Zhisong Chen, Meiling Ye, Lina Liang, Xinguo Ding   +4 more
doaj   +1 more source

The OGT–TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis

Hepatology
Background and Aims: Metabolic dysfunction–associated fatty liver disease (MASLD) encompasses a spectrum of liver pathologies ranging from simple steatosis to metabolic dysfunction–associated steatohepatitis (MASH) with fibrosis.
Zhang, Lei, Han, Cuijuan, Shrestha, Man Mohan, Le, Jiamei, Berger, Kristian, Huang, Yiheng, Desrouleaux, Reina, Wang, Eric, Nagy, Laszlo, Yang, Xiaoyong   +9 more
openaire   +3 more sources

O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism

Nature Communications
Viral infection induces robust reprogramming of metabolic pathways in host cells. However, whether host metabolic enzymes detect viral components remains unknown. Our group and others previously identified O-GlcNAc transferase (OGT), an important glucose
Hong Dong, Chenxi Liang, Junjie Zhang, Weidong Wu, Nitesh Kumar, Zihao Liu, Yajun Sun, Zhiwei Liao, Xiaolin Cheng, Yanbao Yu, Yong Zhang, Michael J. Holtzman, Jianrong Li, Kymberly M. Gowdy, Paul G. Thomas, Jovica D. Badjic, Anjun Ma, Qin Ma, Jacob S. Yount, Shan-Lu Liu, Haitao Wen   +20 more
doaj   +1 more source

Mapping of OGT in theE. colichromosome

Nucleic Acids Research, 1989
P M, Potter, L, Harris, G P, Margison
openaire   +3 more sources

Monetary Policy Rules in the BRICS: How Important is Nonlinearity? [PDF]

Given limited research on monetary policy rules in emerging markets, this paper estimates monetary policy rules for five key emerging market economies: Brazil, Russia, India, China and South Africa (BRICS) analysing whether the monetary authority reacts ...
Fredj Jawadi, Ricardo M. Sousa, Sushanta K. Mallick   +2 more
core  

Estimation and inference in unstable nonlinear least squares models [PDF]

In this paper, we extend Bai and Perron's (1998, Econometrica, pp. 47-78) method for detecting multiple breaks to nonlinear models. To that end, we consider a nonlinear model that can be estimated via nonlinear least squares (NLS) and features a limited ...
Boldea, Otilia, Hall, Alastair R.
core   +1 more source