Results 21 to 30 of about 14,068 (233)
O-GlcNAcylation and Cancer [PDF]
, 2022 This book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcription and as a link between nutrition and epigenetic ...
Belkoura, Ikram, Lefebvre, Tony
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O-GlcNAcylation in health and neurodegenerative diseases [PDF]
Experimental & Molecular Medicine, 2021 AbstractO-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular pathways involved in transcription, translation, and proteostasis.
Byeong Eun Lee +2 more
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Chemistry-Assisted Proteomic Profiling of O-GlcNAcylation
Frontiers in Chemistry, 2021 The modification on proteins with O-linked N-acetyl-β-D-glucosamine (O-GlcNAcylation) is essential for normal cell physiology. Dysregulation of O-GlcNAcylation leads to many human diseases, such as cancer, diabetes and neurodegenerative diseases ...
Qiang Zhu, Wen Yi
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Recently, we observed an increase in O-GlcNAc (O-linked-ß-N-acetylglucosamine) modification, and signal transducer and activator of transcription proteins 3 (STAT3) expression in primary retinal vascular endothelial cells (RVECs) under ...
Chong Xu +4 more
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Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice [PDF]
Open Biology, 2019 O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease.
Villo Muha +13 more
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O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]
, 2015 Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R +8 more
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Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). [PDF]
, 2013 O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events.
Chen, Xi +11 more
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O-GlcNAcylation in Renal (Patho)Physiology
International Journal of Molecular Sciences, 2022 Kidneys maintain internal milieu homeostasis through a well-regulated manipulation of body fluid composition. This task is performed by the correlation between structure and function in the nephron. Kidney diseases are chronic conditions impacting healthcare programs globally, and despite efforts, therapeutic options for its treatment are limited.
Rodrigo P. Silva-Aguiar +4 more
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Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]
, 2012 Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M. +8 more
core +2 more sources
O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function
Frontiers in Endocrinology, 2021 The dynamic cycling of N-acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes.
Jie Ning +5 more
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