Results 31 to 40 of about 14,068 (233)

O-GlcNAcylation at the center of antitumor immunity

Current Opinion in Biotechnology, 2023
The post-translational modification known as O-GlcNAcylation is a highly dysregulated process in tumors, and a key contributor to malignant transformation. In contrast, after three decades since its discovery, very little has been revealed about this process in the immune system.
Graham A Heieis, Bart Everts
openaire   +2 more sources

O‐GlcNAcylation and hyaluronan synthesis

The FASEB Journal, 2012
The intracellular regulation of HA synthesis throughout O‐GlcNacylation is investigated. It was reported that the HA precursor UDP‐N‐acetylglucosamine (UDP‐GlcNac) and UDP glucuronic acid availability modulates of HA synthesis. In this study, we tested the role of O‐GlcNacylation, a type of cytoplasmic protein O‐glycosylation to ...
PASSI, ALBERTO, VIGETTI, DAVIDE, DELEONIBUS, SARA, VIOLA, MANUELA, KAROUSOU, EVGENIA, MORETTO, PAOLA, Bartolini B., DE LUCA, GIANCARLO   +7 more
openaire   +2 more sources

Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs [PDF]

Asian Spine Journal, 2017
Study DesignHuman herniated discs were obtained from discectomy specimens for the immunohistochemical detection of O-GlcNAc and O-GlcNAcase (OGA)/O-GlcNAc transferase (OGT).PurposeThis study aimed to quantify the extent of O-GlcNAcylation and its ...
Georgios Nikolaou, Aristeidis H. Zibis, Apostolos H. Fyllos, Antonios Katsioulis, Sotirios Sotiriou, Anastasios Kotrotsios, Markos Sgantzos, Aikaterini Vassiou, Dimitrios L. Arvanitis   +8 more
doaj   +1 more source

O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity

Frontiers in Immunology, 2021
Post-translational modifications, including O-GlcNAcylation, play fundamental roles in modulating cellular events, including transcription, signal transduction, and immune signaling.
Junghwa Seo, Junghwa Seo, Yun Soo Park, Yun Soo Park, Tae Hyun Kweon, Tae Hyun Kweon, Jingu Kang, Jingu Kang, Seongjin Son, Seongjin Son, Han Byeol Kim, Yu Ri Seo, Min Jueng Kang, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Jin-Hong Kim, Jin-Hong Kim, Boyoun Park, Boyoun Park, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +24 more
doaj   +1 more source

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. [PDF]

, 2019
Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of ...
Albarran, Eddy, Bieri, Gregor, Ding, Jun B, Pratt, Karishma, Sanchez-Diaz, Cesar, Snethlage, Cedric E, Villeda, Saul A, Wheatley, Elizabeth G, White, Charles W   +8 more
core   +1 more source

Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation [PDF]

, 2017
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O ...
AL Mammen, AT Huddleston, BD Lazarus, BQ Liu, C Betzen, C Kim, CS Arnold, DJ Whitcomb, E Benito, EW Taylor, F Liu, GA Ngoh, GW Hart, HJ Goldberg, HK Lee, J Boehm, J Jo, J Lisman, JE Rexach, JF Alfaro, JH Morrison, JR Erickson, K Liu, K Vosseller, KW Roche, L Gong, LS Griffith, LS Griffith, LT Knapp, M Ogawa, M Robles-Flores, M Tiedge, MK Tallent, MP Housley, NP Marotta, R Okuyama, RJ Konrad, RL Huganir, RN Cole, RN Cole, SA Yuzwa, SN Burke, T Hosokawa, T Kanno, WB Dias, Y Akimoto, Y Skorobogatko, YR Yang, YR Yang, YR Yang, YR Yang, Z Wang   +51 more
core   +1 more source

O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease

Cells, 2022
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease spectrum associated with insulin resistance (IR), from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC).
Yicheng Zhou, Zhangwang Li, Minxuan Xu, Deju Zhang, Jitao Ling, Peng Yu, Yunfeng Shen   +6 more
doaj   +1 more source

Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species [PDF]

, 2018
Overproduction of superoxide anion (•O2-) and O-linked β-N-acetylglucosamine (O-GlcNAc)-modification in the vascular system are contributors to endothelial dysfunction.
Alves-Lopes, Rhéure, Dela Justina, Vanessa, Giachini, Fernanda Regina, Lima, Victor V., Mestriner, Fabíola Leslie, Neves, Karla Bianca, Silva Miguez, Jéssica, Souza-Silva, Leonardo, Tostes, Rita C.   +8 more
core   +2 more sources

O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways [PDF]

PeerJ, 2021
O-GlcNAcylation modifies proteins in serine or threonine residues in the nucleus, cytoplasm, and mitochondria. It regulates a variety of cellular biological processes and abnormal O-GlcNAcylation is associated with diabetes, cancer, cardiovascular ...
Hongshuo Zhang, Zhen Li, Yufei Wang, Ying Kong   +3 more
doaj   +2 more sources

Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells

Molecular Brain, 2021
As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases.
So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo, Dong-Hyung Cho   +8 more
doaj   +1 more source