Results 11 to 20 of about 14,068 (233)
O-GlcNAcylation dictates pyroptosis
Frontiers in ImmunologyO-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating the signaling pathways of pyroptosis.
Yue Lang +4 more
doaj +3 more sources
Mass Spectrometry for O-GlcNAcylation [PDF]
Frontiers in Chemistry, 2021 O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) at proteins with low-abundance expression level and species diversity, shows important roles in plenty of biological processes. O-GlcNAcylations with abnormal expression levels are associated with many diseases. Systematically profiling of O-GlcNAcylation at qualitative or quantitative level
Ruoting Yin +8 more
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Protein O-GlcNAcylation in Health and Diseases. [PDF]
MedComm (2020)ABSTRACT O‐GlcNAcylation is a reversible posttranslational modification of proteins that has garnered significant attention in recent years. By regulating the structure and function of proteins, it plays a critical role in various biological processes.
Ran Z +5 more
europepmc +4 more sources
O-GlcNAcylation and neurodegeneration [PDF]
Brain Research Bulletin, 2017 O-GlcNAcylation is a dynamic form of protein glycosylation which involves the addition of β-d-N-acetylglucosamine (GlcNAc) via an O-linkage to serine or threonine residues of nuclear, cytoplasmic, mitochondrial and transmembrane proteins. The two enzymes responsible for O-GlcNAc cycling are O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA); their ...
Willayat Y, Wani +4 more
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O-GlcNAcylation of kinases [PDF]
Biochemical and Biophysical Research Communications, 2012 Recent evidence indicates that site-specific crosstalk between O-GlcNAcylation and phosphorylation and the O-GlcNAcylation of kinases play an important role in regulating cell signaling. However, relatively few kinases have been analyzed for O-GlcNAcylation.
Wagner B, Dias +2 more
openaire +2 more sources
The role of O-GlcNAcylation in development
Development, 2023 ABSTRACT O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways.
Czajewski, Ignacy +1 more
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O-GlcNAcylation and cardiovascular disease [PDF]
Biochemical Society Transactions, 2017 The post-translational modification of serine and threonine residues of proteins found in numerous subcellular locations by O-linked N-acetylglucosamine (O-GlcNAc) is emerging as a key mediator of many cardiovascular pathophysiological processes.
JaLessa N, Wright +3 more
openaire +2 more sources
O-GlcNAcylation Prediction: An Unattained Objective
Advances and Applications in Bioinformatics and Chemistry, 2021 O-GlcNAcylation is an essential post-translational modification (PTM) in mammalian cells. It consists in the addition of a N-acetylglucosamine (GlcNAc) residue onto serines or threonines by an O-GlcNAc transferase (OGT). Inhibition of OGT is lethal, and misregulation of this PTM can lead to diverse pathologies including diabetes, Alzheimer's disease ...
Theo Mauri +5 more
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O-GlcNAcylation: The Sweet Side of Epigenetics
Epigenetics & Chromatin, 2023 Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function without altering the DNA sequence. Histones can also undergo post-translational O-GlcNAcylation, a rather understudied modification that plays ...
Thomas Dupas +2 more
openaire +3 more sources
O-GlcNAcylation and Metabolic Reprograming in Cancer [PDF]
Frontiers in Endocrinology, 2014 Although cancer metabolism has received considerable attention over the past decade, our knowledge on its specifics is still fragmentary. Altered cellular metabolism is one of the most important hallmarks of cancer. Cancer cells exhibit aberrant glucose metabolism characterized by aerobic glycolysis, a phenomenon known as Warburg effect.
Jóźwiak, Paweł +3 more
openaire +5 more sources