StrucGAP: a modular, streamlined and traceable data mining platform for structural and site-specific glycoproteomics [PDF]
Nature CommunicationsThe rapidly developing search engines for glycopeptide identification and accumulated high-resolution glycoproteomic data underscore the need for robust downstream data mining platforms towards subsequently functional and mechanistic studies.
Muyao Yang +9 more
doaj +2 more sources
Advancement in Clinical Glycomics and Glycoproteomics for Congenital Disorders of Glycosylation: Progress and Challenges Ahead [PDF]
BiomedicinesCongenital disorders of glycosylation (CDG) are a group of rare, multisystemic genetic diseases caused by defects in glycan biosynthesis and protein glycosylation.
Nurulamin Abu Bakar, Nurul Izzati Hamzan
doaj +2 more sources
Journal of Advanced ResearchIntroduction: The human plasma glycoproteome holds enormous potential to identify personalized biomarkers for diagnostics. Glycoproteomics has matured into a technology for plasma N-glycoproteome analysis but further evolution towards clinical ...
Hans J C T Wessels +2 more
exaly +3 more sources
The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches [PDF]
Frontiers in NutritionHuman milk lactoferrin (hmLF), a sialic acid-rich iron-binding milk glycoprotein, is essential for infant development, playing a key role in immune defense and gut maturation.
Jing Zhu +14 more
doaj +2 more sources
Advanced ScienceProtein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li +9 more
doaj +2 more sources
Clinical glycoproteomics: methods and diseases
MedCommGlycoproteins, representing a significant proportion of posttranslational products, play pivotal roles in various biological processes, such as signal transduction and immune response.
Kaixin Lei, Lijun Zhao, Yong Zhang
exaly +2 more sources
Are viral vector-mediated therapies compatible with aberrant glycosylation? [PDF]
Molecular Therapy: Methods & Clinical DevelopmentThe ability of adeno-associated viruses (AAVs) to transduce host cells relies on interactions with glycan moieties on the cellular surface.
I.J.J. Muffels +6 more
doaj +2 more sources
Multi-Omics Characterization of a Novel SSR4 Variant in Congenital Disorders of Glycosylation [PDF]
MetabolitesBackground: Congenital disorders of glycosylation (CDG) are rare inborn errors of metabolism with multisystemic manifestations. SSR4-CDG is an ultra-rare X-linked subtype caused by pathogenic variants in SSR4, a component of the translocon-associated ...
Nurulamin Abu Bakar +6 more
doaj +2 more sources
GproDIA enables data-independent acquisition glycoproteomics with comprehensive statistical control
Nature Communications, 2021 Data independent acquisition (DIA) proteomics provides deep coverage and high quantitative accuracy, but is not yet well established in glycoproteomics. Here, the authors develop a DIA-based glycoproteomics workflow with stringent statistical controls to
Yi Yang +6 more
doaj +1 more source
Protein Arginylation Is Regulated during SARS-CoV-2 Infection
Viruses, 2023 Background: In 2019, the world witnessed the onset of an unprecedented pandemic. By February 2022, the infection by SARS-CoV-2 has already been responsible for the death of more than 5 million people worldwide.
Janaina Macedo-da-Silva +14 more
doaj +1 more source