StrucGAP: a modular, streamlined and traceable data mining platform for structural and site-specific glycoproteomics [PDF]
Nature CommunicationsThe rapidly developing search engines for glycopeptide identification and accumulated high-resolution glycoproteomic data underscore the need for robust downstream data mining platforms towards subsequently functional and mechanistic studies.
Muyao Yang +9 more
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Advancement in Clinical Glycomics and Glycoproteomics for Congenital Disorders of Glycosylation: Progress and Challenges Ahead [PDF]
BiomedicinesCongenital disorders of glycosylation (CDG) are a group of rare, multisystemic genetic diseases caused by defects in glycan biosynthesis and protein glycosylation.
Nurulamin Abu Bakar, Nurul Izzati Hamzan
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The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches [PDF]
Frontiers in NutritionHuman milk lactoferrin (hmLF), a sialic acid-rich iron-binding milk glycoprotein, is essential for infant development, playing a key role in immune defense and gut maturation.
Jing Zhu +14 more
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Journal of Advanced ResearchIntroduction: The human plasma glycoproteome holds enormous potential to identify personalized biomarkers for diagnostics. Glycoproteomics has matured into a technology for plasma N-glycoproteome analysis but further evolution towards clinical ...
Hans Jct Wessels +2 more
exaly +3 more sources
Toward spatial glycomics and glycoproteomics: Innovations and applications [PDF]
BBA AdvancesIn this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field.
Patcharaporn Boottanun +2 more
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Are viral vector-mediated therapies compatible with aberrant glycosylation? [PDF]
Molecular Therapy: Methods & Clinical DevelopmentThe ability of adeno-associated viruses (AAVs) to transduce host cells relies on interactions with glycan moieties on the cellular surface.
I.J.J. Muffels +6 more
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GproDIA enables data-independent acquisition glycoproteomics with comprehensive statistical control
Nature Communications, 2021 Data independent acquisition (DIA) proteomics provides deep coverage and high quantitative accuracy, but is not yet well established in glycoproteomics. Here, the authors develop a DIA-based glycoproteomics workflow with stringent statistical controls to
Yi Yang +6 more
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Protein Arginylation Is Regulated during SARS-CoV-2 Infection
Viruses, 2023 Background: In 2019, the world witnessed the onset of an unprecedented pandemic. By February 2022, the infection by SARS-CoV-2 has already been responsible for the death of more than 5 million people worldwide.
Janaina Macedo-da-Silva +14 more
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STAR Protocols, 2020 Summary: This protocol describes an integrated approach for analyzing site-specific N- and O-linked glycosylation of SARS-CoV-2 spike protein by mass spectrometry.
Katelyn E. Rosenbalm +4 more
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Profound N-glycan remodelling accompanies MHC-II immunopeptide presentation
Frontiers in Immunology, 2023 Immunopeptidomics, the study of peptide antigens presented on the cell surface by the major histocompatibility complex (MHC), offers insights into how our immune system recognises self/non-self in health and disease.
Hayley Goodson +10 more
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