Results 11 to 20 of about 4,441 (208)

The Hitchhiker's guide to glycoproteomics [PDF]

Biochemical Society Transactions, 2021
Protein glycosylation is one of the most common post-translational modifications that are essential for cell function across all domains of life. Changes in glycosylation are considered a hallmark of many diseases, thus making glycoproteins important ...
Packer, Nicolle H, Oliveira, Tiago, Kolarich, Daniel, Thaysen-Andersen, Morten   +3 more
core   +4 more sources

Deep Learning Prediction of O-Glycopeptide Tandem Mass Spectra Enhances O-Glycoproteomics. [PDF]

Adv Sci (Weinh)
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Zong Y, Wang Y, Qiao L.
europepmc   +3 more sources

Glycoproteomics

Nature Reviews Methods Primers, 2022
Protein glycosylation involves the co-translational or post-translational addition of glycans to proteins and is a crucial protein modification in health and disease.
Schjoldager, Katrine, Halim, A, Bertozzi, CR, Vakhrushev, Sergey Y., Aoki-Kinoshita, Kiyoko F., Riley, Nicholas M., Wandall, HH, Bagdonaite, I, Scott, Nichollas E., Thaysen-Andersen, Morten, Malaker, Stacy A., Riley, NM, Parker, BL, Scott, NE, Malaker, SA, Vakhrushev, SY, Thaysen-Andersen, M, Bertozzi, Carolyn R., Schjoldager, K, Nesvizhskii, AI, Nesvizhskii, Alexey I., Polasky, Daniel A., Aoki-Kinoshita, KF, Halim, Adnan, Wandall, Hans H., Parker, Benjamin L., Bagdonaite, Ieva, Polasky, DA   +27 more
core   +4 more sources

Microbial glycoproteomics

Current Opinion in Structural Biology, 2017
Mass spectrometry-based "-omics" technologies are important tools for global and detailed mapping of post-translational modifications. Protein glycosylation is an abundant and important post translational modification widespread throughout all domains of
Halim, Adnan, Jan Haug Anonsen, Adnan Halim, Anonsen, Jan Haug   +3 more
core   +4 more sources

Mass Spectrometry Strategies for O-Glycoproteomics

Cells
Glycoproteomics has accelerated in recent decades owing to numerous innovations in the analytical workflow. In particular, new mass spectrometry strategies have contributed to inroads in O-glycoproteomics, a field that lags behind N-glycoproteomics due ...
Amanda Helms, Jennifer S. Brodbelt
doaj   +2 more sources

Toward spatial glycomics and glycoproteomics: Innovations and applications

BBA Advances
In this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field.
Patcharaporn Boottanun, Sayaka Fuseya, Atsushi Kuno   +2 more
doaj   +2 more sources

Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics

Journal of Proteome Research, 2018
Glycoproteomics is an important recent advance in the field of glycoscience. In glycomics, glycan structures are comprehensively analyzed after glycans are released from glycoproteins.
Zhang, Hui, Narimatsu, Hisashi, Henrik Clausen (117282), Li Cheng (228291), Kaji, Hiroyuki, Sheng-Ce Tao (1305759), Kuno, Atsushi, Hiroyuki Kaji, Hiroyuki Kaji (505920), Yangyang Sun (1446925), Sergey Y. Vakhrushev, Sheng-Ce Tao, Vakhrushev, Sergey Y, Noro, Erika, Xia Zou (108788), Akira Togayachi (754136), Akira Togayachi, Hisashi Narimatsu (309772), Henrik Clausen, Zou, Xia, Hui Zhang (7197), Hui Zhang, Erika Noro, Cheng, Li, Erika Noro (1364763), Xia Zou, Sergey Y. Vakhrushev (715996), Chiaki Nagai-Okatani, Nagai-Okatani, Chiaki, Atsushi Kuno (7003), Atsushi Kuno, Togayachi, Akira, Chiaki Nagai-Okatani (2818309), Yangyang Sun, Li Cheng, Tao, Sheng-Ce, Sun, Yangyang, Hisashi Narimatsu, Clausen, Henrik   +38 more
core   +4 more sources

Clinical glycoproteomics: methods and diseases

MedComm
Glycoproteins, representing a significant proportion of posttranslational products, play pivotal roles in various biological processes, such as signal transduction and immune response.
Yujia Wang, Kaixin Lei, Lijun Zhao, Yong Zhang   +3 more
doaj   +3 more sources

Glycomics, glycoproteomics and the immune system

Current Opinion in Chemical Biology, 2012
Glycomics and glycoproteomics have become indispensible tools in the study of glycoconjugates. Mass spectrometry based methods are standardly used to study the proteome and/or glycome and these approaches are capable of providing both, qualitative and ...
Kolarich, D., Seeberger, P. H., Kolarich, Daniel, Lepenies, B., Seeberger, Peter H, Lepenies, Bernd, Seeberger, Peter H., Seeberger, P.   +7 more
core   +5 more sources

Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. [PDF]

, 2021
Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but their relative performance remains untested.
Cao, Weiqian, Alagesan, Kathirvel, Edwards, Nathan, Kawahara, Rebeca, Kolarich, Daniel, Cheng, Kai, Choo, Matthew S, Hu, Yingwei, Bern, Marshall, Chalkley, Robert J, Huang, Yifan, Goldman, Radoslav, Hoffmann, Marcus, Packer, Nicki, Chernykh, Anastasia, et al.   +15 more
core   +4 more sources