Results 11 to 20 of about 4,132 (206)
The Hitchhiker's guide to glycoproteomics [PDF]
Biochemical Society Transactions, 2021 Protein glycosylation is one of the most common post-translational modifications that are essential for cell function across all domains of life. Changes in glycosylation are considered a hallmark of many diseases, thus making glycoproteins important diagnostic and prognostic biomarker candidates and therapeutic targets.
Tiago Oliveira +3 more
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Nature Reviews Methods Primers, 2022 Protein glycosylation involves the co-translational or post-translational addition of glycans to proteins and is a crucial protein modification in health and disease. The aim of glycoproteomics is to understand how glycosylation shapes biological processes by understanding peptide sequences, glycan structures and sites of modification in a system-wide ...
Ieva Bagdonaite +13 more
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Mass Spectrometry Strategies for O-Glycoproteomics
CellsGlycoproteomics has accelerated in recent decades owing to numerous innovations in the analytical workflow. In particular, new mass spectrometry strategies have contributed to inroads in O-glycoproteomics, a field that lags behind N-glycoproteomics due ...
Amanda Helms, Jennifer S. Brodbelt
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Current Opinion in Structural Biology, 2017 Mass spectrometry-based "-omics" technologies are important tools for global and detailed mapping of post-translational modifications. Protein glycosylation is an abundant and important post translational modification widespread throughout all domains of life.
Halim, Adnan, Anonsen, Jan Haug
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Toward spatial glycomics and glycoproteomics: Innovations and applications
BBA AdvancesIn this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field.
Patcharaporn Boottanun +2 more
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Molecules, 2021 Protein glycosylation that mediates interactions among viral proteins, host receptors, and immune molecules is an important consideration for predicting viral antigenicity.
William E. Hackett, Joseph Zaia
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Glycoproteomics in neurodegenerative diseases [PDF]
Mass Spectrometry Reviews, 2009 AbstractProtein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to ...
Hwang, Hyejin +17 more
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Journal of Proteome Research, 2018 Glycoproteomics is an important recent advance in the field of glycoscience. In glycomics, glycan structures are comprehensively analyzed after glycans are released from glycoproteins. However, a major limitation of glycomics is the lack of insight into glycoprotein functions.
Hisashi Narimatsu +12 more
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Glycomics, glycoproteomics and the immune system
Current Opinion in Chemical Biology, 2012 Glycomics and glycoproteomics have become indispensible tools in the study of glycoconjugates. Mass spectrometry based methods are standardly used to study the proteome and/or glycome and these approaches are capable of providing both, qualitative and quantitative information using top down techniques. The human immune system marks a particular area of
Kolarich, Daniel +2 more
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Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. [PDF]
, 2021 Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but their relative performance remains untested.
Cao, Weiqian +15 more
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