Results 41 to 50 of about 6,118 (218)
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. [PDF]
, 2020 The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is ...
Coon, Joshua +5 more
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Glycoproteomics and clinical applications [PDF]
PROTEOMICS – Clinical Applications, 2010 AbstractGlycosylation is the most structurally complicated and diverse type of protein modifications. Protein glycosylation has long been recognized to play fundamental roles in many biological processes, as well as in disease genesis and progression. Glycoproteomics focuses on characterization of proteins modified by carbohydrates.
Yuan, Tian, Hui, Zhang
openaire +2 more sources
Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates [PDF]
, 2016 Protein O-mannosylation is a post-translational modification essential for correct development of mammals. In humans, deficient O-mannosylation results in severe congenital muscular dystrophies often associated with impaired brain and eye development ...
Bartels, MF +10 more
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A Perspective on Extracellular Vesicles Proteomics
Frontiers in Chemistry, 2017 Increasing attention has been given to secreted extracellular vesicles (EVs) in the past decades, especially in the portrayal of their molecular cargo and role as messengers in both homeostasis and pathophysiological conditions.
Livia Rosa-Fernandes +6 more
doaj +1 more source
Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry [PDF]
, 2016 Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be ...
Altmann, F. +8 more
core +2 more sources
Glycoproteomic Analysis of Antibodies
Molecular & Cellular Proteomics, 2013 Antibody glycosylation has been shown to change with various processes. This review presents mass spectrometric approaches for antibody glycosylation analysis at the level of released glycans, glycopeptides, and intact protein. With regard to IgG fragment crystallizable glycosylation, mass spectrometry has shown its potential for subclass-specific ...
Zauner, G. +6 more
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A high-resolution N-glycoproteome landscape of aging mouse ovary
Redox BiologyOvarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one of the most important protein modifications has been especially unexplored in this context.
Yongqi Wu +11 more
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Glycomics & Glycoproteomics in Glycoconjugate journal [PDF]
Glycoconjugate Journal, 2016 Glycoconjugates belong without doubt to the most complex and diverse molecules found in nature. They are crucial for both prokaryotic and eukaryotic life despite the fact that the glycosylation pathways and building blocks do diverge tremendously between the different phylogenetic kingdoms [1].
Kolarich, D., Wuhrer, M.
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Frontiers in Chemistry, 2022 Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy ...
Wenjuan Zeng +13 more
doaj +1 more source
Glycomic analysis of high density lipoprotein shows a highly sialylated particle. [PDF]
, 2014 Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL.
German, J Bruce +6 more
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