Results 41 to 50 of about 3,095 (176)

Glycomics & Glycoproteomics in Glycoconjugate journal [PDF]

Glycoconjugate Journal, 2016
Glycoconjugates belong without doubt to the most complex and diverse molecules found in nature. They are crucial for both prokaryotic and eukaryotic life despite the fact that the glycosylation pathways and building blocks do diverge tremendously between the different phylogenetic kingdoms [1].
Kolarich, D., Wuhrer, M.
openaire   +3 more sources

A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates

Frontiers in Chemistry, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus utilizes the extensively glycosylated spike (S) protein protruding from the viral envelope to bind to angiotensin-converting enzyme-related carboxypeptidase (ACE2) as its primary ...
Qiong Wang, Yan Wang, Shuang Yang, Shuang Yang, Changyi Lin, Lateef Aliyu, Yiqun Chen, Lisa Parsons, Yuan Tian, Hongpeng Jia, Andrew Pekosz, Michael J. Betenbaugh, John F. Cipollo   +12 more
doaj   +1 more source

Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics

Advanced Science, EarlyView.
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley   +1 more source

Precision N-Glycoproteomic Profiling of Murine Peritoneal Macrophages After Different Stimulations

Frontiers in Immunology, 2021
Macrophages are important immune cells that participate in both innate and adaptive immune responses, such as phagocytosis, recognition of molecular patterns, and activation of the immune response.
Lujie Yang, Tianqi Gong, Huali Shen, Jiangnan Pei, Lei Zhang, Quanqing Zhang, Yuanyu Huang, Zuojian Hu, Ziyue Pan, Pengyuan Yang, Ling Lin, Hongxiu Yu   +11 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science
Glycosylation plays an important role in regulating innate and adaptive immunity. With promising advances in structural and site‐specific glycoproteomics, how to thoroughly extract important information from these multi‐dimensional data has become ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source

Glycoproteomics Technologies in Glycobiotechnology

, 2020
Glycosylation is a key factor determining the pharmacological properties of biotherapeutics, including their stability, solubility, bioavailability, pharmacokinetics, and immunogenicity. As such, comprehensive information about glycosylation of biotherapeutics is critical to demonstrate similarity.
Kathirvel Alagesan, Marcus Hoffmann, Erdmann Rapp, Daniel Kolarich   +3 more
openaire   +5 more sources

Comparative glycoproteomics: approaches and applications [PDF]

Briefings in Functional Genomics and Proteomics, 2008
Glycosylation plays fundamental roles in controlling various biological processes. Therefore, glycosylation analysis has become an important target for proteomic research and has great potential for clinical applications. With the continuous development and refinement of glycoprotein isolation methods, increasing attention has been directed to the ...
Xin, Wei, Lingjun, Li
openaire   +2 more sources

Structural and site-specific characterization of distinctive N-glycans with heavy fucosylation in human semen

Carbohydrate Polymer Technologies and Applications
Heavy fucosylation (fucose residues ≥ 6 per glycan) has been previously reported in human semen with unclear precise site-specific glycan structures. In current study, we characterized heavily fucosylated glycoproteins as a distinctive feature of human ...
Miaomiao Xin, Yintai Xu, Shanshan You, Cheng Li, Jiechen Shen, Bojing Zhu, Qiaohong Zhao, Juanzi Shi, Shisheng Sun   +8 more
doaj   +1 more source