Results 61 to 70 of about 4,132 (206)

Comparative glycoproteomics: approaches and applications [PDF]

Briefings in Functional Genomics and Proteomics, 2008
Glycosylation plays fundamental roles in controlling various biological processes. Therefore, glycosylation analysis has become an important target for proteomic research and has great potential for clinical applications. With the continuous development and refinement of glycoprotein isolation methods, increasing attention has been directed to the ...
Xin, Wei, Lingjun, Li
openaire   +2 more sources

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science
Glycosylation plays an important role in regulating innate and adaptive immunity. With promising advances in structural and site‐specific glycoproteomics, how to thoroughly extract important information from these multi‐dimensional data has become ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source

Structural and site-specific characterization of distinctive N-glycans with heavy fucosylation in human semen

Carbohydrate Polymer Technologies and Applications
Heavy fucosylation (fucose residues ≥ 6 per glycan) has been previously reported in human semen with unclear precise site-specific glycan structures. In current study, we characterized heavily fucosylated glycoproteins as a distinctive feature of human ...
Miaomiao Xin, Yintai Xu, Shanshan You, Cheng Li, Jiechen Shen, Bojing Zhu, Qiaohong Zhao, Juanzi Shi, Shisheng Sun   +8 more
doaj   +1 more source

Overcoming Challenges and Opening New Opportunities in Glycoproteomics

Biomolecules, 2013
Glycoproteomics has emerged as a prime area of interest within the field of proteomics because glycoproteins have been shown to function as biomarkers for disease and as promising therapeutic targets. A significant challenge in the study of glycoproteins
Bruce A. Macher, Leslie C. Timpe, Alejandro A. Corona, Sucharita M. Dutta, Christina Litsakos-Cheung, Ten-Yang Yen   +5 more
doaj   +1 more source

Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies

Transfusion, EarlyView.
Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson   +33 more
wiley   +1 more source

Multi-attribute Glycan Identification and FDR Control for Glycoproteomics

, 2021
PSM tables associated with the publication "Multi-attribute Glycan Identification and FDR Control for Glycoproteomics." PSM tables are named according to the corresponding figure in the manuscript.
Nesvizhskii, Alexey, Geiszler, Daniel, Yu, Fengchao, Polasky, Daniel   +3 more
core   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 599-623, July/August 2026.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Glycoproteomics: A Balance between High-Throughput and In-Depth Analysis [PDF]

, 2017
Glycoproteomics is an important subdiscipline of proteomics. Mass spectrometry (MS)-based glycoproteomics has relied so far on two levels of analysis, targeting either the released glycans or digested glycopeptides.
Heck, Albert J R, Franc, Vojtech, Yang, Yang, Biomolecular Mass Spectrometry and Proteomics, Afd Biomol.Mass Spect. and Proteomics   +4 more
core   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source