Results 61 to 70 of about 6,118 (218)

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science
Glycosylation plays an important role in regulating innate and adaptive immunity. With promising advances in structural and site‐specific glycoproteomics, how to thoroughly extract important information from these multi‐dimensional data has become ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source

Structural and site-specific characterization of distinctive N-glycans with heavy fucosylation in human semen

Carbohydrate Polymer Technologies and Applications
Heavy fucosylation (fucose residues ≥ 6 per glycan) has been previously reported in human semen with unclear precise site-specific glycan structures. In current study, we characterized heavily fucosylated glycoproteins as a distinctive feature of human ...
Miaomiao Xin, Yintai Xu, Shanshan You, Cheng Li, Jiechen Shen, Bojing Zhu, Qiaohong Zhao, Juanzi Shi, Shisheng Sun   +8 more
doaj   +1 more source

Overcoming Challenges and Opening New Opportunities in Glycoproteomics

Biomolecules, 2013
Glycoproteomics has emerged as a prime area of interest within the field of proteomics because glycoproteins have been shown to function as biomarkers for disease and as promising therapeutic targets. A significant challenge in the study of glycoproteins
Bruce A. Macher, Leslie C. Timpe, Alejandro A. Corona, Sucharita M. Dutta, Christina Litsakos-Cheung, Ten-Yang Yen   +5 more
doaj   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Structural and functional glycosphingolipidomics by glycoblotting with aminooxy-functionalized gold nanoparticle [PDF]

, 2008
Glycosphingolipids (GSLs) synthesized in Golgi apparatus by sequential transfer of sugar residues to a ceramide lipid anchor are ubiquitously distributing on vertebrate plasma membranes.
Midori Abe, Noriko Nagahori, Shin-Ichiro Nishimura   +2 more
core   +1 more source

Applications of omics approaches to the development of microbiological risk assessment using RNA virus dose–response models as a case study [PDF]

, 2014
The last decade has seen a huge increase in the amount of “omics” data available and in our ability to interpret those data. The aim of this paper is to consider how omics techniques can be used to improve and refine microbiological risk assessment ...
Bassett, J., Gale, P., Hill, A., Kelly, L., Le Mark, Y., McClure, P., Soumpasis, I.   +6 more
core   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Highlights of B/D‐HPP and HPP Resource Pillar Workshops at 12th Annual HUPO World Congress of Proteomics [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106985/1/pmic7698 ...
Aebersold, Ruedi, Bader, Gary D., Edwards, Aled M., Eyk, Jennifer, Kussman, Martin, Omenn, Gilbert S., Qin, Jun   +6 more
core   +1 more source

M2BPgs-HCC: An Automated Multilectin Bead Array Indicating Aberrant Glycosylation Signatures Toward Hepatitis C Virus-Associated Hepatocellular Carcinoma Prognosis

Molecules
Regular monitoring of patients with a history of hepatitis C virus (HCV) infection is critical for the detection and management of hepatocellular carcinoma (HCC).
Hiroko Shimazaki, Haruki Uojima, Kazumi Yamasaki, Tomomi Obayashi, Sayaka Fuseya, Takashi Sato, Masashi Mizokami, Atsushi Kuno   +7 more
doaj   +1 more source