Results 61 to 70 of about 4,441 (208)

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science
Glycosylation plays an important role in regulating innate and adaptive immunity. With promising advances in structural and site‐specific glycoproteomics, how to thoroughly extract important information from these multi‐dimensional data has become ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Structural and site-specific characterization of distinctive N-glycans with heavy fucosylation in human semen

Carbohydrate Polymer Technologies and Applications
Heavy fucosylation (fucose residues ≥ 6 per glycan) has been previously reported in human semen with unclear precise site-specific glycan structures. In current study, we characterized heavily fucosylated glycoproteins as a distinctive feature of human ...
Miaomiao Xin, Yintai Xu, Shanshan You, Cheng Li, Jiechen Shen, Bojing Zhu, Qiaohong Zhao, Juanzi Shi, Shisheng Sun   +8 more
doaj   +1 more source

Overcoming Challenges and Opening New Opportunities in Glycoproteomics

Biomolecules, 2013
Glycoproteomics has emerged as a prime area of interest within the field of proteomics because glycoproteins have been shown to function as biomarkers for disease and as promising therapeutic targets. A significant challenge in the study of glycoproteins
Bruce A. Macher, Leslie C. Timpe, Alejandro A. Corona, Sucharita M. Dutta, Christina Litsakos-Cheung, Ten-Yang Yen   +5 more
doaj   +1 more source

Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies

Transfusion, EarlyView.
Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson   +33 more
wiley   +1 more source

Fragmentation characteristics of glycopeptides [PDF]

, 2013
Mass spectrometric analysis of glycopeptides is an emerging strategy for analysis of glycosylation patterns. Here we present an approach using energy resolved collision induced decomposition (CID) spectra to determine structural features of glycopeptides.
Jekő, Anita, Drahos, László, Révész, Ágnes, Krenyácz, Judit, Tóth, Eszter, Ozohanics, Olivér, Vékey, Károly   +6 more
core   +1 more source

Multi-attribute Glycan Identification and FDR Control for Glycoproteomics

, 2021
PSM tables associated with the publication "Multi-attribute Glycan Identification and FDR Control for Glycoproteomics." PSM tables are named according to the corresponding figure in the manuscript.
Nesvizhskii, Alexey, Geiszler, Daniel, Yu, Fengchao, Polasky, Daniel   +3 more
core   +1 more source

M2BPgs-HCC: An Automated Multilectin Bead Array Indicating Aberrant Glycosylation Signatures Toward Hepatitis C Virus-Associated Hepatocellular Carcinoma Prognosis

Molecules
Regular monitoring of patients with a history of hepatitis C virus (HCV) infection is critical for the detection and management of hepatocellular carcinoma (HCC).
Hiroko Shimazaki, Haruki Uojima, Kazumi Yamasaki, Tomomi Obayashi, Sayaka Fuseya, Takashi Sato, Masashi Mizokami, Atsushi Kuno   +7 more
doaj   +1 more source

Glycoproteomic Signatures of IgG Subclass N‐Glycosylation Reveal Molecular Endotypes in Idiopathic Inflammatory Myopathies

MedComm, Volume 7, Issue 10, October 2026.
• EThcD‐sceHCD‐MS/MS and updated PANDA software decode IgG N‐glycosylation in IIMs. • Unsupervised clustering reveals three novel glyco‐endotypes matching clinical phenotypes. • A seven‐glycopeptide model enables robust endotype prediction beyond conventional subtypes.
Tong Wu, Yanhong Li, Yingying Ling, Yinlan Wu, Jing Zhao, Lu Cheng, Chunyu Tan, Yi Zhang, Yong Zhang, Yi Liu   +9 more
wiley   +1 more source

Glycoproteomics Technologies in Glycobiotechnology

, 2020
Glycosylation is a key factor determining the pharmacological properties of biotherapeutics, including their stability, solubility, bioavailability, pharmacokinetics, and immunogenicity. As such, comprehensive information about glycosylation of biotherapeutics is critical to demonstrate similarity.
Kathirvel Alagesan, Marcus Hoffmann, Erdmann Rapp, Daniel Kolarich   +3 more
openaire   +5 more sources