Results 51 to 60 of about 4,132 (206)

Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation

Frontiers in Chemistry, 2021
The α1,6-fucosyltransferase (encoded by FUT8 gene) is the key enzyme transferring fucose to the innermost GlcNAc residue on an N-glycan through an α-1,6 linkage in the mammalian cells.
Ganglong Yang, Qiong Wang, Lijun Chen, Michael J. Betenbaugh, Hui Zhang, Hui Zhang   +5 more
doaj   +1 more source

Glycoproteomic Analysis of Antibodies

Molecular & Cellular Proteomics, 2013
Antibody glycosylation has been shown to change with various processes. This review presents mass spectrometric approaches for antibody glycosylation analysis at the level of released glycans, glycopeptides, and intact protein. With regard to IgG fragment crystallizable glycosylation, mass spectrometry has shown its potential for subclass-specific ...
Zauner, G., Selman, M.H.J., Bondt, A., Rombouts, Y., Blank, D., Deelder, A.M., Wuhrer, M.   +6 more
openaire   +4 more sources

Glycomics & Glycoproteomics in Glycoconjugate journal [PDF]

Glycoconjugate Journal, 2016
Glycoconjugates belong without doubt to the most complex and diverse molecules found in nature. They are crucial for both prokaryotic and eukaryotic life despite the fact that the glycosylation pathways and building blocks do diverge tremendously between the different phylogenetic kingdoms [1].
Kolarich, D., Wuhrer, M.
openaire   +3 more sources

Databases and Associated Tools for Glycomics and Glycoproteomics

, 2016
The access to biodatabases for glycomics and glycoproteomics has proven to be essential for current glycobiological research. This chapter presents available databases that are devoted to different aspects of glycobioinformatics.
Rojas-Macias, Miguel A., Lisacek, Frederique, Mariethoz, Julien, Julien Mariethoz, Ståhle, J., Rudd, Pauline M., Stahle, Jonas, Karlsson, N. G.,, Jin, Chunsheng, Widmalm, G., Abrahams, Jodie L., Alocci, Davide, Barbara Adamczyk, Mullen, E., Alocci, D., Jodie L. Abrahams, Miguel A. Rojas-Macias, Abrahams, J. L., Chunsheng Jin, Campbell, M. P., Jonas Ståhle, Rudd, P. M., Pauline M. Rudd, Mariethoz, J., Campbell, Matthew P., Davide Alocci, Rojas-Macias, Miguel A.,, Karlsson, Niclas G., Ståhle, Jonas,, Widmalm, Göran, Packer, Nicolle H., Elaine Mullen, Widmalm, Göran,, Mullen, Elaine, Göran Widmalm, Packer, N. H., Lisacek, F., Jin, Chunsheng,, Adamczyk, Barbara,, Niclas G. Karlsson, Frederique Lisacek, Adamczyk, Barbara, Matthew P. Campbell, Nicolle H. Packer   +43 more
core   +1 more source

“Ghost” Fragment Ions in Structure and Site-Specific Glycoproteomics Analysis

, 2023
Mass spectrometry (MS) can unlock crucial insights into the intricate world of glycosylation analysis. Despite its immense potential, the qualitative and quantitative analysis of isobaric glycopeptide structures remains one of the most daunting hurdles ...
Diana Campos (422207), Qiang Yang, Radoslav Goldman, Lai-Xi Wang, Diana Campos, Guanghui Zong, Qiang Yang (135832), Miloslav Sanda (1325664), Michael Girgis (10706922), Radoslav Goldman (10706), Michael Girgis, Guanghui Zong (1528576), Miloslav Sanda, Lai-Xi Wang (266700)   +13 more
core   +1 more source

A comprehensive N-glycoproteome atlas reveals tissue-specific glycan remodeling but non-random structural microheterogeneities

Nature Communications
The mouse is a key model in biomedical research, yet its tissue-specific glycoproteome remains incompletely characterized due to glycan complexity and microheterogeneity.
Yongqi Wu, Muyao Yang, Yongchao Xu, Li Jia, Jun Li, Xiaohan Wang, Jiayu Zhao, Yinli Cai, Yiwen Zhang, Shisheng Sun   +9 more
doaj   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Glycoproteomics Technologies in Glycobiotechnology

, 2020
Glycosylation is a key factor determining the pharmacological properties of biotherapeutics, including their stability, solubility, bioavailability, pharmacokinetics, and immunogenicity. As such, comprehensive information about glycosylation of biotherapeutics is critical to demonstrate similarity.
Kathirvel Alagesan, Marcus Hoffmann, Erdmann Rapp, Daniel Kolarich   +3 more
openaire   +5 more sources