Results 51 to 60 of about 3,095 (176)

Overcoming Challenges and Opening New Opportunities in Glycoproteomics

Biomolecules, 2013
Glycoproteomics has emerged as a prime area of interest within the field of proteomics because glycoproteins have been shown to function as biomarkers for disease and as promising therapeutic targets. A significant challenge in the study of glycoproteins
Bruce A. Macher, Leslie C. Timpe, Alejandro A. Corona, Sucharita M. Dutta, Christina Litsakos-Cheung, Ten-Yang Yen   +5 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Toward spatial glycomics and glycoproteomics: Innovations and applications

BBA Advances
In this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field.
Patcharaporn Boottanun, Sayaka Fuseya, Atsushi Kuno   +2 more
doaj   +1 more source

Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies

Transfusion, EarlyView.
Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson   +33 more
wiley   +1 more source

Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction

Frontiers in Pharmacology, 2018
Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue degeneration after permanent myocardial infarction (PMI ...
Martin Houde, Martin Houde, Adel Schwertani, Hanène Touil, Louisane Desbiens, Otman Sarrhini, Roger Lecomte, Martin Lepage, Hugo Gagnon, Shinji Takai, Gunnar Pejler, Gunnar Pejler, Danielle Jacques, Fernand Gobeil, Robert Day, Pedro D’Orléans-Juste   +15 more
doaj   +1 more source

Comparison of Three Glycoproteomic Methods for the Analysis of the Secretome of CHO Cells Treated with 1,3,4-O-Bu₃ManNAc

Bioengineering, 2020
Comprehensive analysis of the glycoproteome is critical due to the importance of glycosylation to many aspects of protein function. The tremendous complexity of this post-translational modification, however, makes it difficult to adequately characterize ...
Joseph L. Mertz, Shisheng Sun, Bojiao Yin, Yingwei Hu, Rahul Bhattacharya, Michael J. Bettenbaugh, Kevin J. Yarema, Hui Zhang   +7 more
doaj   +1 more source

Expanding the Chondroitin Sulfate Glycoproteome — But How Far?

Frontiers in Cell and Developmental Biology, 2021
Chondroitin sulfate proteoglycans (CSPGs) are found at cell surfaces and in connective tissues, where they interact with a multitude of proteins involved in various pathophysiological processes.
Fredrik Noborn, Mahnaz Nikpour, Andrea Persson, Jonas Nilsson, Jonas Nilsson, Göran Larson   +5 more
doaj   +1 more source

Gastroprotective Effects of Nettle‐ and Carob‐Enriched Snail Mucus in a Rat Model of Gastric Injury: Role of Antioxidant and Anti‐Inflammatory Mechanisms

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Dietary enrichment of Helix aspersa mucus with Urtica dioica or Ceratonia siliqua extracts increased its phenolic, flavonoid, protein, and glycoprotein content in a dose‐dependent manner, with nettle showing the strongest effect. In an ethanol‐induced rat model of gastric ulcer, the 30% nettle‐enriched mucus (SSUD30%) markedly reduced gastric lesions ...
Khaoula Gharbi, Slimen Selmi, Soumaya Wahabi, Hanen Kahlaoui, Karima Tlili, Stefano D'allacqua, Hichem Sebai   +6 more
wiley   +1 more source

Prediction of glycopeptide fragment mass spectra by deep learning

Nature Communications
Deep learning has achieved a notable success in mass spectrometry-based proteomics and is now emerging in glycoproteomics. While various deep learning models can predict fragment mass spectra of peptides with good accuracy, they cannot cope with the non ...
Yi Yang, Qun Fang
doaj   +1 more source