Results 51 to 60 of about 4,441 (208)

A high-resolution N-glycoproteome landscape of aging mouse ovary

Redox Biology
Ovarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one of the most important protein modifications has been especially unexplored in this context.
Yongqi Wu, Zhida Zhang, Yongchao Xu, Yingjie Zhang, Lin Chen, Yiwen Zhang, Ke Hou, Muyao Yang, Zhehui Jin, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source

Glycoproteomic Analysis of Antibodies

Molecular & Cellular Proteomics, 2013
Antibody glycosylation has been shown to change with various processes. This review presents mass spectrometric approaches for antibody glycosylation analysis at the level of released glycans, glycopeptides, and intact protein. With regard to IgG fragment crystallizable glycosylation, mass spectrometry has shown its potential for subclass-specific ...
Zauner, G., Selman, M.H.J., Bondt, A., Rombouts, Y., Blank, D., Deelder, A.M., Wuhrer, M.   +6 more
openaire   +4 more sources

Databases and Associated Tools for Glycomics and Glycoproteomics

, 2016
The access to biodatabases for glycomics and glycoproteomics has proven to be essential for current glycobiological research. This chapter presents available databases that are devoted to different aspects of glycobioinformatics.
Rojas-Macias, Miguel A., Lisacek, Frederique, Mariethoz, Julien, Julien Mariethoz, Ståhle, J., Rudd, Pauline M., Stahle, Jonas, Karlsson, N. G.,, Jin, Chunsheng, Widmalm, G., Abrahams, Jodie L., Alocci, Davide, Barbara Adamczyk, Mullen, E., Alocci, D., Jodie L. Abrahams, Miguel A. Rojas-Macias, Abrahams, J. L., Chunsheng Jin, Campbell, M. P., Jonas Ståhle, Rudd, P. M., Pauline M. Rudd, Mariethoz, J., Campbell, Matthew P., Davide Alocci, Rojas-Macias, Miguel A.,, Karlsson, Niclas G., Ståhle, Jonas,, Widmalm, Göran, Packer, Nicolle H., Elaine Mullen, Widmalm, Göran,, Mullen, Elaine, Göran Widmalm, Packer, N. H., Lisacek, F., Jin, Chunsheng,, Adamczyk, Barbara,, Niclas G. Karlsson, Frederique Lisacek, Adamczyk, Barbara, Matthew P. Campbell, Nicolle H. Packer   +43 more
core   +1 more source

A comprehensive N-glycoproteome atlas reveals tissue-specific glycan remodeling but non-random structural microheterogeneities

Nature Communications
The mouse is a key model in biomedical research, yet its tissue-specific glycoproteome remains incompletely characterized due to glycan complexity and microheterogeneity.
Yongqi Wu, Muyao Yang, Yongchao Xu, Li Jia, Jun Li, Xiaohan Wang, Jiayu Zhao, Yinli Cai, Yiwen Zhang, Shisheng Sun   +9 more
doaj   +1 more source

“Ghost” Fragment Ions in Structure and Site-Specific Glycoproteomics Analysis

, 2023
Mass spectrometry (MS) can unlock crucial insights into the intricate world of glycosylation analysis. Despite its immense potential, the qualitative and quantitative analysis of isobaric glycopeptide structures remains one of the most daunting hurdles ...
Diana Campos (422207), Qiang Yang, Radoslav Goldman, Lai-Xi Wang, Diana Campos, Guanghui Zong, Qiang Yang (135832), Miloslav Sanda (1325664), Michael Girgis (10706922), Radoslav Goldman (10706), Michael Girgis, Guanghui Zong (1528576), Miloslav Sanda, Lai-Xi Wang (266700)   +13 more
core   +1 more source

Glycomics & Glycoproteomics in Glycoconjugate journal [PDF]

Glycoconjugate Journal, 2016
Glycoconjugates belong without doubt to the most complex and diverse molecules found in nature. They are crucial for both prokaryotic and eukaryotic life despite the fact that the glycosylation pathways and building blocks do diverge tremendously between the different phylogenetic kingdoms [1].
Kolarich, D., Wuhrer, M.
openaire   +3 more sources

A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates

Frontiers in Chemistry, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus utilizes the extensively glycosylated spike (S) protein protruding from the viral envelope to bind to angiotensin-converting enzyme-related carboxypeptidase (ACE2) as its primary ...
Qiong Wang, Yan Wang, Shuang Yang, Shuang Yang, Changyi Lin, Lateef Aliyu, Yiqun Chen, Lisa Parsons, Yuan Tian, Hongpeng Jia, Andrew Pekosz, Michael J. Betenbaugh, John F. Cipollo   +12 more
doaj   +1 more source

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source

Precision N-Glycoproteomic Profiling of Murine Peritoneal Macrophages After Different Stimulations

Frontiers in Immunology, 2021
Macrophages are important immune cells that participate in both innate and adaptive immune responses, such as phagocytosis, recognition of molecular patterns, and activation of the immune response.
Lujie Yang, Tianqi Gong, Huali Shen, Jiangnan Pei, Lei Zhang, Quanqing Zhang, Yuanyu Huang, Zuojian Hu, Ziyue Pan, Pengyuan Yang, Ling Lin, Hongxiu Yu   +11 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source