Results 31 to 40 of about 6,118 (218)

Glycoproteomics in neurodegenerative diseases [PDF]

Mass Spectrometry Reviews, 2009
AbstractProtein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to ...
Hwang, Hyejin, Zhang, Jianpeng, Chung, Kathryn A., Leverenz, James B., Zabetian, Cyrus P., Peskind, Elaine R., Jankovic, Joseph, Su, Zhen, Hancock, Aneeka M., Pan, Catherine, Montine, Thomas J., Pan, Sheng, Nutt, John, Albin, Roger L., Gearing, Marla, Beyer, Richard P., Shi, Min, Zhang, Jing   +17 more
openaire   +3 more sources

N-glycoproteins in Plant Cell Walls: A Survey

Plants, 2022
Cell walls are an extracellular compartment specific to plant cells, which are not found in animal cells. Their composition varies between cell types, plant species, and physiological states.
Hélène San Clemente, Elisabeth Jamet
doaj   +1 more source

Lectin magnetic bead array for biomarker discovery [PDF]

, 2010
Alterations in protein glycosylation play an important role in patho-physiology, and much effort has been devoted to detecting glycoprotein biomarkers.
Hill, Michelle M., Jones, Alun, Loo, Dorothy   +2 more
core   +1 more source

Differential Glycosite Profiling—A Versatile Method to Compare Membrane Glycoproteomes

Molecules, 2021
Glycosylation is the most prevalent and varied form of post-translational protein modifications. Protein glycosylation regulates multiple cellular functions, including protein folding, cell adhesion, molecular trafficking and clearance, receptor ...
Malwina Michalak, Martin Simon Kalteis, Aysel Ahadova, Matthias Kloor, Mark Kriegsmann, Katharina Kriegsmann, Uwe Warnken, Dominic Helm, Jürgen Kopitz   +8 more
doaj   +1 more source

Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6‐deficient spondylodysplastic Ehlers–Danlos syndrome

JIMD Reports, 2022
The spondylodysplastic type of Ehlers–Danlos syndrome (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate ...
Mahnaz Nikpour, Fredrik Noborn, Jonas Nilsson, Tim Van Damme, Olivier Kaye, Delfien Syx, Fransiska Malfait, Göran Larson   +7 more
doaj   +1 more source

Plasma glycoproteomic biomarkers identify metastatic melanoma patients with reduced clinical benefit from immune checkpoint inhibitor therapy

Frontiers in Immunology, 2023
The clinical success of immune-checkpoint inhibitors (ICI) in both resected and metastatic melanoma has confirmed the validity of therapeutic strategies that boost the immune system to counteract cancer.
Chad Pickering, Paul Aiyetan, Gege Xu, Alan Mitchell, Rachel Rice, Yana G. Najjar, Joseph Markowitz, Joseph Markowitz, Lisa M. Ebert, Lisa M. Ebert, Lisa M. Ebert, Michael P. Brown, Michael P. Brown, Michael P. Brown, Gonzalo Tapia-Rico, Dennie Frederick, Xin Cong, Daniel Serie, Klaus Lindpaintner, Flavio Schwarz, Genevieve M. Boland   +20 more
doaj   +1 more source

Serum Glycoproteomic Alterations in Patients with Diabetic Retinopathy

Proteomes, 2020
The precise molecular mechanisms of diabetic retinopathy (DR) pathogenesis are unclear, and treatment options are limited. There is an urgent need to discover and develop novel therapeutic targets for the treatment of this disease.
Ashok Sharma, James Cox, Joshua Glass, Tae Jin Lee, Sai Karthik Kodeboyina, Wenbo Zhi, Lane Ulrich, Zachary Lukowski, Shruti Sharma   +8 more
doaj   +1 more source

The Need for Community Standards to Enable Accurate Comparison of Glycoproteomics Algorithm Performance

Molecules, 2021
Protein glycosylation that mediates interactions among viral proteins, host receptors, and immune molecules is an important consideration for predicting viral antigenicity.
William E. Hackett, Joseph Zaia
doaj   +1 more source

GALNT10 Affects O-Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer. [PDF]

Adv Sci (Weinh)
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Zhang Y, Zuha A, Wu Z, Luo A, Jin B, Sun Q, Li Y, Liu Q, Guo H, Shang C.   +9 more
europepmc   +2 more sources

Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities [PDF]

, 2017
Trypanosoma brucei causes African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two of which, TbSTT3A and TbSTT3B, are expressed in the bloodstream form of the parasite.
Abraham, Acosta-Serrano, Acosta-Serrano, Aebi, Allison, Anders Jinnelov, Aslett, Atrih, Bandini, Bangs, Bangs, Boehm, Brandes, Butter, Cardoso de Almeida, Castillo-Acosta, Castillo-Acosta, Castillo-Acosta, Castro, Cherepanova, Cherepanova, Choi, Crooks, Damerow, Damerow, Engstler, Ferguson, Ferguson, Güther, Güther, Hese, Hirumi, Horn, Izquierdo, Izquierdo, Izquierdo, Jackson, Jones, Kalb, Kelleher, Kelley, Krissinel, LaCount, Liaqat Ali, Lingnau, Lizak, Maishman, Manthri, Maria Lucia S. Güther, Mehlert, Mehlert, Michael A.J. Ferguson, Michele Tinti, Miller, Mohorko, Nagamune, Nasab, Oberholzer, Peck, Pettersen, Poljak, Ruiz-Canada, Salmon, Schulz, Schwede, Shrimal, Siegel, Steverding, Tiengwe, Treumann, Urbaniak, Urbaniak, Vacic, Wirtz, Woycechowsky, Yan, Zamze, Zamze, Zielinska   +78 more
core   +3 more sources