Results 31 to 40 of about 3,095 (176)

Glycoproteomics and clinical applications [PDF]

PROTEOMICS – Clinical Applications, 2010
AbstractGlycosylation is the most structurally complicated and diverse type of protein modifications. Protein glycosylation has long been recognized to play fundamental roles in many biological processes, as well as in disease genesis and progression. Glycoproteomics focuses on characterization of proteins modified by carbohydrates.
Yuan, Tian, Hui, Zhang
openaire   +2 more sources

Serum Glycoproteomic Alterations in Patients with Diabetic Retinopathy

Proteomes, 2020
The precise molecular mechanisms of diabetic retinopathy (DR) pathogenesis are unclear, and treatment options are limited. There is an urgent need to discover and develop novel therapeutic targets for the treatment of this disease.
Ashok Sharma, James Cox, Joshua Glass, Tae Jin Lee, Sai Karthik Kodeboyina, Wenbo Zhi, Lane Ulrich, Zachary Lukowski, Shruti Sharma   +8 more
doaj   +1 more source

The Need for Community Standards to Enable Accurate Comparison of Glycoproteomics Algorithm Performance

Molecules, 2021
Protein glycosylation that mediates interactions among viral proteins, host receptors, and immune molecules is an important consideration for predicting viral antigenicity.
William E. Hackett, Joseph Zaia
doaj   +1 more source

A Perspective on Extracellular Vesicles Proteomics

Frontiers in Chemistry, 2017
Increasing attention has been given to secreted extracellular vesicles (EVs) in the past decades, especially in the portrayal of their molecular cargo and role as messengers in both homeostasis and pathophysiological conditions.
Livia Rosa-Fernandes, Victória Bombarda Rocha, Victor Corasolla Carregari, Andrea Urbani, Andrea Urbani, Giuseppe Palmisano, Giuseppe Palmisano   +6 more
doaj   +1 more source

A high-resolution N-glycoproteome landscape of aging mouse ovary

Redox Biology
Ovarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one of the most important protein modifications has been especially unexplored in this context.
Yongqi Wu, Zhida Zhang, Yongchao Xu, Yingjie Zhang, Lin Chen, Yiwen Zhang, Ke Hou, Muyao Yang, Zhehui Jin, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source

Comparative N-Glycoproteomics Analysis of Clinical Samples Via Different Mass Spectrometry Dissociation Methods

Frontiers in Chemistry, 2022
Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy ...
Wenjuan Zeng, Shanshan Zheng, Tao Su, Jiahan Cheng, Yonghong Mao, Yi Zhong, Yueqiu Liu, Jianhai Chen, Wanjun Zhao, Tianhai Lin, Fang Liu, Guisen Li, Hao Yang, Yong Zhang   +13 more
doaj   +1 more source

Glycoproteomic Analysis of Antibodies

Molecular & Cellular Proteomics, 2013
Antibody glycosylation has been shown to change with various processes. This review presents mass spectrometric approaches for antibody glycosylation analysis at the level of released glycans, glycopeptides, and intact protein. With regard to IgG fragment crystallizable glycosylation, mass spectrometry has shown its potential for subclass-specific ...
Zauner, G., Selman, M.H.J., Bondt, A., Rombouts, Y., Blank, D., Deelder, A.M., Wuhrer, M.   +6 more
openaire   +4 more sources

Mass Spectrometry Strategies for O-Glycoproteomics

Cells
Glycoproteomics has accelerated in recent decades owing to numerous innovations in the analytical workflow. In particular, new mass spectrometry strategies have contributed to inroads in O-glycoproteomics, a field that lags behind N-glycoproteomics due ...
Amanda Helms, Jennifer S. Brodbelt
doaj   +1 more source

A comprehensive N-glycoproteome atlas reveals tissue-specific glycan remodeling but non-random structural microheterogeneities

Nature Communications
The mouse is a key model in biomedical research, yet its tissue-specific glycoproteome remains incompletely characterized due to glycan complexity and microheterogeneity.
Yongqi Wu, Muyao Yang, Yongchao Xu, Li Jia, Jun Li, Xiaohan Wang, Jiayu Zhao, Yinli Cai, Yiwen Zhang, Shisheng Sun   +9 more
doaj   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source