Results 31 to 40 of about 356,021 (162)

Galactose deficient IgA1 (GD-IgA1) in skin and serum from patients with skin-limited and systemic IgA Vasculitis.

, 2019
BACKGROUND: IgA-vasculitis (IgAV) encompasses a systemic form involving kidneys, gut, skin or joints, and a skin-limited form. One characteristic feature of systemic IgAV is deposition of galactose-deficient IgA1 (GD-IgA1) in kidneys (as in IgA ...
S Mayer-Hain (7767194), M Neufeld (7767185), K Molyneux (7767188), J Ehrchen (7767200), Y Suzuki (6917537), J Barratt (7703606), C Sunderkötter (7767203), C von Hodenberg (7767197), KI Pappelbaum (7767191)   +8 more
core   +7 more sources

Diagnostic Potential of Plasma IgA1 O-Glycans in Discriminating IgA Nephropathy From Other Glomerular Diseases and Healthy Participants

Frontiers in Molecular Biosciences, 2022
Background: Aberrant O-glycosylation of IgA1 plays an important role in IgA nephropathy pathogenesis. Previous proteomic studies analyzed O-glycans of the circulating IgA1 hinge region and found that the N-acetylgalactosamine (GalNAc) and galactose ...
Shuyu Zhang, Haidan Sun, Zejian Zhang, Menglin Li, Zhengguang Guo, Wenling Ye, Guangyan Cai, Wei Sun, Mingxi Li   +8 more
doaj   +1 more source

Galactose-Deficient IgA1 in African Americans with IgA Nephropathy [PDF]

Clinical Journal of the American Society of Nephrology, 2010
Serum levels of galactose-deficient IgA1 (Gd-IgA1) are elevated and heritable in Caucasian and Asian patients with IgA nephropathy (IgAN), but have not been characterized in African Americans (AA). Our objective was to determine whether serum Gd-IgA1 levels are increased in AA patients with IgAN and whether this is a heritable trait in this group.Blood
M Colleen, Hastings, Zina, Moldoveanu, Bruce A, Julian, Jan, Novak, John T, Sanders, Kim R, McGlothan, Ali G, Gharavi, Robert J, Wyatt   +7 more
openaire   +2 more sources

Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy

Kidney International Reports, 2020
Introduction: Galactose-deficient IgA1 (Gd-IgA1) and related IgA/IgG immune complexes have been identified as the key drivers in the pathogenesis of IgA nephropathy (IgAN).
Manliu Wang, Jicheng Lv, Xue Zhang, Pei Chen, Minghui Zhao, Hong Zhang   +5 more
doaj   +1 more source

Autoantibodies Targeting Galactose-Deficient IgA1 Associate with Progression of IgA Nephropathy [PDF]

Journal of the American Society of Nephrology, 2012
Mesangial and circulating IgA1 with aberrantly glycosylated hinge region O-glycans characterize IgA nephropathy (IgAN). Unlike healthy individuals, some IgA1 is galactose deficient in patients with IgAN, leaving terminal N-acetylgalactosamine residues in the hinge region exposed.
Francois, Berthoux, Hitoshi, Suzuki, Lise, Thibaudin, Hiroyuki, Yanagawa, Nicolas, Maillard, Christophe, Mariat, Yasuhiko, Tomino, Bruce A, Julian, Jan, Novak   +8 more
openaire   +2 more sources

Oxidative Stress and Galactose-Deficient IgA1 as Markers of Progression in IgA Nephropathy [PDF]

Clinical Journal of the American Society of Nephrology, 2011
SummaryBackground and objectivesWe assessed the activation of the oxidative stress pathway in patients with IgA nephropathy (IgAN), while evaluating the classic marker of the disease (galactose-deficient serum IgA1).Design, setting, participants, & measurementsSera from 292 patients and 69 healthy controls from Italy and the United States were ...
Camilla R, Suzuki H, Daprà V, Loiacono E, Peruzzi L, Amore A, Ghiggeri GM, MAZZUCCO, Gianna, Scolari F, Gharavi AG, Appel GB, Troyanov S, Novak J, Julian BA, Coppo R.   +14 more
openaire   +4 more sources

Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy

Frontiers in Immunology, 2020
IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African Americans.
Katerina Zachova, Petr Kosztyu, Josef Zadrazil, Karel Matousovic, Karel Vondrak, Petr Hubacek, Bruce A. Julian, Zina Moldoveanu, Zdenek Novak, Klara Kostovcikova, Milan Raska, Milan Raska, Jiri Mestecky, Jiri Mestecky, Jiri Mestecky   +14 more
doaj   +1 more source

Racial heterogeneity of IgA1 hinge-region O-glycoforms in patients with IgA nephropathy

iScience, 2022
Summary: Galactose (Gal)-deficient IgA1 (Gd-IgA1) is involved in IgA nephropathy (IgAN) pathogenesis. To reflect racial differences in clinical characteristics, we assessed disease- and race-specific heterogeneity in the O-glycosylation of the IgA1 hinge
Yukako Ohyama, Hisateru Yamaguchi, Soshiro Ogata, Samantha Chiurlia, Sharon N. Cox, Nikoletta-Maria Kouri, Maria J. Stangou, Kazuki Nakajima, Hiroki Hayashi, Daijo Inaguma, Midori Hasegawa, Yukio Yuzawa, Naotake Tsuboi, Matthew B. Renfrow, Jan Novak, Aikaterini A. Papagianni, Francesco P. Schena, Kazuo Takahashi   +17 more
doaj   +1 more source

Enzymatic sialylation of IgA1 O-glycans: implications for studies of IgA nephropathy. [PDF]

PLoS ONE, 2014
Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc).
Kazuo Takahashi, Milan Raska, Milada Stuchlova Horynova, Stacy D Hall, Knud Poulsen, Mogens Kilian, Yoshiyuki Hiki, Yukio Yuzawa, Zina Moldoveanu, Bruce A Julian, Matthew B Renfrow, Jan Novak   +11 more
doaj   +1 more source

Assigning immunoglobulin class from single-cell transcriptomes in IgA1-secreting versus membrane subpopulations

BioTechniques, 2021
IgA nephropathy (IgAN) is an autoimmune disease characterized by renal glomerular immunodeposits enriched for galactose-deficient IgA1 (Gd-IgA1; autoantigen) with the corresponding IgG autoantibodies.
Colin Reily, Nuo Xu, David K Crossman
doaj   +1 more source