Results 21 to 30 of about 356,021 (162)

Clinical Significance of Galactose-Deficient IgA1 by KM55 in Patients with IgA Nephropathy [PDF]

Kidney & Blood Pressure Research, 2019
Background: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. A monoclonal antibody, KM55, which specifically recognizes Gd-
Kai Zhang, Qiongqiong Li, Yaru Zhang, Wenya Shang, Li Wei, Hongfen Li, Shan Gao, Tiekun Yan, Junya Jia, Youxia Liu, Shan Lin   +10 more
doaj   +3 more sources

Absence of glomerular IgA1 deposition despite overexpression of galactose-deficient IgA1 in the B cell c1galt1 knockout mouse

Kidney International
INTRODUCTION: Aberrant O-linked glycosylation of the IgA hinge segment resulting in galactose-deficient IgA1 (Gd-IgA1) is frequently observed in patients with IgA nephropathy (IgAN), and it is hypothesized to be pathogenic. Here, we genetically disrupted
Xujie Zhou (14160788), Tong Xie (3592568), Jing Jin (18601), Hong Zhang (25820), Shu Zhu (356373), Yuemiao Zhang (17949660), Jonathan Barratt (20341977), Zhao Zhang (52732), Jicheng Lv (141481), Wenmin Tian (10159971), Yong Zhang (5893), Xingzi Liu (13474513), Jingyi Wu (1472761), Daniel P Gale (10571691)   +13 more
core   +7 more sources

Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy [PDF]

Journal of Clinical Medicine, 2022
Wen-Chih Chiang, Wei-Chou Lin, Yen-Ling Chiu   +2 more
exaly   +2 more sources

Clinical Significance of the Intensity of Glomerular Galactose-Deficient IgA1 Deposition in IgA Nephropathy. [PDF]

Kidney Int Rep, 2022
Nakayama M, Suzuki H, Fukao Y, Lee M, Kano T, Suzuki Y.   +5 more
europepmc   +3 more sources

Glomerular Galactose-Deficient IgA1 Deposition in 192 Autopsy Cases in Japan. [PDF]

Nephrology (Carlton)
ABSTRACT Aim Glomerular IgA deposition is incidentally observed in asymptomatic individuals; however, it remains unclear whether these cases represent a preclinical stage of IgA nephropathy (IgAN).
Nihei Y, Aoki R, Matsuzaki K, Koizumi A, Saeki H, Sakai I, Kihara M, Yao T, Suzuki Y.   +8 more
europepmc   +3 more sources

Helicobacter pylori infection is associated with elevated galactose-deficient IgA1 in IgA nephropathy. [PDF]

Ren Fail, 2020
Mucosal immunity plays an important role in the pathogenesis of IgA nephropathy (IgAN). This study aimed to investigate if infection of Helicobacter pylori (H. pylori), a common bacteria in the gastrointestinal tract, associated with IgAN. This study included 261 patients with IgAN and 46 healthy controls.
Liu XZ, Zhang YM, Jia NY, Zhang H.
europepmc   +5 more sources

Interaction between GALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy. [PDF]

J Am Soc Nephrol, 2021
Significance Statement Galactose-deficient IgA1 plays a key role in the pathogenesis of IgA nephropathy. Although variability in serum levels of galactose-deficient IgA1 has a strong genetic component, the genetic link between this molecule and IgA nephropathy has not yet been clearly determined.
Wang YN, Zhou XJ, Zhou XJ, Chen P, Yu GZ, Zhang X, Hou P, Liu LJ, Shi SF, Lv JC, Zhang H.   +10 more
europepmc   +4 more sources

ELL2 Is Downregulated and Associated with Galactose-Deficient IgA1 in IgA Nephropathy. [PDF]

Dis Markers, 2019
Background. Galactose-deficient IgA1 (Gd-IgA1) is an important causal factor in IgA nephropathy; however, the underlying mechanism for the production of Gd-IgA1 is unknown. The elongation factor for RNA polymerase II (ELL2), which encoded a key component of the superelongation complex (SEC), drives secretory-specific Ig mRNA production. Methods.
Liu Y, Zheng J, Zhao N, Jia J, Yan T.
europepmc   +4 more sources

Plasma Galactose-Deficient IgA1 and C3 and CKD Progression in IgA Nephropathy. [PDF]

Clin J Am Soc Nephrol, 2019
Background and objectives Increased circulating galactose-deficient IgA1 and subsequently complement activation both play important roles in the pathophysiology of IgA nephropathy. However, their relationship to disease severity and progression remains unclear.
Chen P, Yu G, Zhang X, Xie X, Wang J, Shi S, Liu L, Lv J, Zhang H.   +8 more
europepmc   +4 more sources

Pathogenesis of IgA Vasculitis: An Up-To-Date Review

Frontiers in Immunology, 2021
Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls.
Yan Song, Yan Song, Yan Song, Yan Song, Yan Song, Xiaohan Huang, Xiaohan Huang, Xiaohan Huang, Xiaohan Huang, Xiaohan Huang, Guizhen Yu, Guizhen Yu, Guizhen Yu, Guizhen Yu, Guizhen Yu, Jianjun Qiao, Jun Cheng, Jun Cheng, Jun Cheng, Jun Cheng, Jun Cheng, Jianyong Wu, Jianyong Wu, Jianyong Wu, Jianyong Wu, Jianyong Wu, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen   +30 more
doaj   +1 more source