Results 11 to 20 of about 356,021 (162)

Clinical Relevance of Serum Galactose Deficient IgA1 in Patients with IgA Nephropathy [PDF]

Journal of Clinical Medicine, 2020
New biomarkers of IgA nephropathy (IgAN) are needed for non-invasive diagnosis and appropriate treatment. There is emerging evidence that galactose deficient IgA1 (Gd-IgA1) is a pivotal molecule in the pathogenesis of IgAN.
Ji Yoon Kong, Jin Sug Kim, Sang Ho Lee
exaly   +6 more sources

Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy. [PDF]

PLoS ONE, 2018
IgA nephropathy is an autoimmune disease characterized by IgA1-containing glomerular immune deposits. We previously proposed a multi-hit pathogenesis model in which patients with IgA nephropathy have elevated levels of circulatory IgA1 with some O ...
William J Placzek, Hiroyuki Yanagawa, Yuko Makita, Matthew B Renfrow, Bruce A Julian, Dana V Rizk, Yusuke Suzuki, Jan Novak, Hitoshi Suzuki   +8 more
doaj   +6 more sources

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway. [PDF]

PLoS Genetics, 2017
Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form of glomerulonephritis worldwide, but specific genetic factors involved in its determination are not known.
Krzysztof Kiryluk, Yifu Li, Zina Moldoveanu, Hitoshi Suzuki, Colin Reily, Ping Hou, Jingyuan Xie, Nikol Mladkova, Sindhuri Prakash, Clara Fischman, Samantha Shapiro, Robert A LeDesma, Drew Bradbury, Iuliana Ionita-Laza, Frank Eitner, Thomas Rauen, Nicolas Maillard, Francois Berthoux, Jürgen Floege, Nan Chen, Hong Zhang, Francesco Scolari, Robert J Wyatt, Bruce A Julian, Ali G Gharavi, Jan Novak   +25 more
doaj   +7 more sources

Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease [PDF]

Journal of Immunology Research, 2014
Immunoglobulin A (IgA) nephropathy (IgAN), the leading cause of primary glomerulonephritis, is characterized by IgA1-containing immunodeposits in the glomeruli. IgAN is a chronic disease, with up to 40% of patients progressing to end-stage renal disease,
Colin Reily, Hiroyuki Ueda, Zhi-Qiang Huang, Jiri Mestecky, Bruce A. Julian, Christopher D. Willey, Jan Novak   +6 more
doaj   +6 more sources

Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls [PDF]

International Journal of Nephrology, 2017
Galactose-deficient IgA1 (Gd-IgA1) is a key pathogenic factor for IgA nephropathy (IgAN) and a potential biomarker for the disease. This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine
John T. Sanders, M. Colleen Hastings, Zina Moldoveanu, Jan Novak, Bruce A. Julian, Zoran Bursac, Robert J. Wyatt   +6 more
doaj   +5 more sources

Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy [PDF]

International Journal of Nephrology, 2012
Introduction. Percentage of galactose-deficient IgA1 (Gd-IgA1) relative to total IgA in serum was recently reported to correlate with proteinuria at time of sampling and during follow-up for pediatric and adult patients with IgA nephropathy. We sought to
M. Colleen Hastings, Sabahat Afshan, John T. Sanders, Oulimata Kane, T. Matthew Eison, Keith K. Lau, Zina Moldoveanu, Bruce A. Julian, Jan Novak, Robert J. Wyatt   +9 more
doaj   +6 more sources

Galactose-Deficient IgA1-Specific Antibody Recognizes GalNAc-Modified Unique Epitope on Hinge Region of IgA1 [PDF]

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2018
Galactose-deficient IgA1 (Gd-IgA1) that exposes GalNAc or sialylated GalNAc has been shown to be associated with disease activity of IgA nephropathy (IgAN). In a previous report, we established an enzyme-linked immunosorbent assay that measures human Gd-IgA1 using a specific monoclonal antibody KM55 (KM55 mAb), and showed that patients with IgAN ...
Kohei Yamasaki, Hitoshi Suzuki, Yusuke Suzuki   +2 more
exaly   +5 more sources

Correction: Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy progression. [PDF]

PLoS One, 2019
Correction: Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy ...
Maixnerova D, Ling C, Hall S, Reily C, Brown R, Neprasova M, Suchanek M, Honsova E, Zima T, Novak J, Tesar V.   +10 more
europepmc   +4 more sources

Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG [PDF]

Kidney International, 1997
Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. IgA1 proteins from sera of patients with IgA nephropathy (IgAN) are galactosylated to a lesser degree than those from healthy controls.
Julian, Bruce A., Radl, Jiri, Tomana, Milan, Matousovic, Karel, Konecny, Karel, Mestecky, Jiri   +5 more
core   +4 more sources

Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy

Kidney International Reports, 2017
IgA nephropathy is a chronic renal disease characterized by mesangial immunodeposits that contain autoantigen, which is aberrantly glycosylated IgA1 with some hinge-region O-glycans deficient in galactose.
Koshi Yamada, Zhi-Qiang Huang, Milan Raska, Colin Reily, Joshua C. Anderson, Hitoshi Suzuki, Hiroyuki Ueda, Zina Moldoveanu, Krzysztof Kiryluk, Yusuke Suzuki, Robert J. Wyatt, Yasuhiko Tomino, Ali G. Gharavi, Amy Weinmann, Bruce A. Julian, Christopher D. Willey, Jan Novak   +16 more
doaj   +2 more sources