Results 1 to 10 of about 1,830 (103)

Autoantibodies Specific for Galactose-Deficient IgA1 in IgA Vasculitis With Nephritis [PDF]

Kidney International Reports, 2019
Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1–specific autoantibodies in pathogenic immune complexes. Renal biopsy histopathologic features of IgA vasculitis (
Bruce A Julian, Robert Wyatt, Hitoshi Suzuki   +2 more
exaly   +4 more sources

LIF/JAK2/STAT1 Signaling Enhances Production of Galactose-Deficient IgA1 by IgA1-Producing Cell Lines Derived From Tonsils of Patients With IgA Nephropathy [PDF]

Kidney International Reports
Introduction: Galactose-deficient IgA1 (Gd-IgA1) plays a key role in the pathogenesis of IgA nephropathy (IgAN). Tonsillectomy has been beneficial to some patients with IgAN, possibly due to the removal of tonsillar cytokine-activated cells producing Gd ...
Hitoshi Suzuki, Colin Reily, Yusuke Suzuki   +2 more
exaly   +4 more sources

Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy [PDF]

Nature Communications
The retention of galactose-deficient IgA1 (Gd-IgA1) in the mesangium is central to IgA nephropathy (IgAN), but its intracellular fate remains unclear. Here, we show that transferrin receptor 1 (TfR1) mediates Gd-IgA1 uptake into mesangial cell lysosomes,
Meijun Si, Jingpeng Fu, Mengting Fang, Yunfei Lu, Junxuan Huang, Haojie Li, Peiyi Wang, Maofu Liao, Jian Zhu, Peiyao Li, Wenzhao Zhong, Zhifei Guo, Wei Yang, Zhiming Ye, Hongli Hu, Xueqing Yu   +15 more
doaj   +2 more sources

Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis [PDF]

Case Reports in Nephrology, 2020
Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN). Furthermore, immunostaining of KM55, an antibody that identifies Gd-IgA1, may
Yuhong Zhao, Youngki Kim, Milind Junghare, Viral Vakil, Xuesong Su, Faqian Li, Lihong Bu   +6 more
doaj   +2 more sources

Assay for Galactose-Deficient IgA1 Enables Mechanistic Studies with Primary Cells from IgA Nephropathy Patients

BioTechniques, 2018
Aims: IgA nephropathy, the most common primary glomerulonephritis worldwide, is characterized by glomerular deposition of galactose-deficient IgA1 and elevated serum levels of this IgA1 glycoform.
Bruce A Julian, Colin Reily, Dana V Rizk
exaly   +3 more sources

Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy progression. [PDF]

PLoS ONE, 2019
BackgroundIgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has serious outcomes with end-stage renal disease developing in 30-50% of patients. The diagnosis requires renal biopsy.
Dita Maixnerova, Chunyan Ling, Stacy Hall, Colin Reily, Rhubell Brown, Michaela Neprasova, Miloslav Suchanek, Eva Honsova, Tomas Zima, Jan Novak, Vladimir Tesar   +10 more
doaj   +2 more sources

Glomerular galactose-deficient IgA1 expression analysis in pediatric patients with glomerular diseases [PDF]

Scientific Reports, 2020
Galactose-deficient IgA1 (Gd-IgA1) is important in the pathogenesis of IgA nephropathy (IgAN). A Gd-IgA1-specific monoclonal antibody (KM55) has revealed glomerular Gd-IgA1 deposition solely in patients with IgAN and IgA vasculitis with nephritis (IgAV-N)
Shinya Ishiko, Tomoko Horinouchi, Rika Fujimaru, Yuko Shima, Hiroshi Kaito, Ryojiro Tanaka, Shingo Ishimori, Atsushi Kondo, Sadayuki Nagai, Yuya Aoto, Nana Sakakibara, China Nagano, Tomohiko Yamamura, Momoka Yoshimura, Koichi Nakanishi, Junya Fujimura, Naohiro Kamiyoshi, Hiroaki Nagase, Norishige Yoshikawa, Kazumoto Iijima, Kandai Nozu   +20 more
doaj   +2 more sources

Clinical Significance of Serum Galactose-Deficient IgA1 Level in Children with IgA Nephropathy [PDF]

Journal of Immunology Research, 2020
This study was aimed at investigating the clinical significance of serum galactose-deficient IgA1 (Gd-IgA1) levels measured by a novel lectin-independent enzyme-linked immunosorbent assay (ELISA) using an anti-Gd-IgA1 monoclonal antibody (KM55) as a ...
Hitoshi Irabu, Masaki Shimizu, Shuya Kaneko, Natsumi Inoue, Mao Mizuta, Kazuhide Ohta, Akihiro Yachie   +6 more
doaj   +2 more sources

Maternally inherited diabetes and deafness complicated by mesangial galactose-deficient IgA1 deposits: a case report [PDF]

BMC Nephrology, 2018
Background Maternally inherited diabetes and deafness (MIDD), a mitochondrial genetic disorder, typically affects the kidneys and results in end-stage renal disease.
Keiji Sugai, Hiroyuki Ueda, Keita Morimoto, Mai Tanaka, Daisuke Takahashi, Akio Nakashima, Junichiro Kato, Hiroshi Takahashi, Yutaka Yamaguchi, Tetsuya Kawamura, Kazushige Hanaoka, Yoichi Miyazaki, Takashi Yokoo   +12 more
doaj   +2 more sources

Galactose-Deficient IgA1 as a Candidate Urinary Marker of IgA Nephropathy [PDF]

Journal of Clinical Medicine, 2022
Mingfeng Lee, Hitoshi Suzuki, Jin Sug Kim   +2 more
exaly   +2 more sources