Results 81 to 90 of about 356,021 (162)

Serum levels of galactose-deficient IgA are elevated in patients with IgA nephropathy but do not correlate to disease activity or progression

BMC Nephrology, 2023
Introduction IgA nephropathy (IgAN) is the most common glomerulonephritis globally. Because of the heterogeneity of the disease prognostic biomarkers are highly needed.
Sigridur Elíasdóttir, Alina Khramova, Aso Saeed, Gregor Guron, Roberto Boi, Johan Mölne, Kerstin Ebefors, Jenny Nyström   +7 more
doaj   +1 more source

The Association Between Serum Immunoglobulin G Titers Against Porphyromonas gingivalis and Chronic Kidney Disease in Patients With Rheumatoid Arthritis and Periodontitis: A Retrospective Cohort Study

Clinical and Experimental Dental Research, Volume 12, Issue 1, February 2026.
ABSTRACT Objectives Chronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic Porphyromonas gingivalis are risk factors for CKD. However, the association of serum immunity to P. gingivalis and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in ...
Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta   +5 more
wiley   +1 more source

Comparison of the glomerular staining intensity of (Gd-IgA1) (KM55) and plasma Gd-IgA1 (KM55) concentrations.

, 2023
There was no significant association between the glomerular staining intensity of Gd-IgA1 and the plasma Gd-IgA1 concentration. The data were examined for statistical significance using a simple regression analysis.
Seigo Ito (1353945), Yusuke Suzuki (525707), Ryota Nomura (630559), Daiki Matsuoka (13777279), Kazuhiko Nakano (630560), Shuhei Naka (13777276), Ryosuke Aoki (14709763), Michiyo Matsumoto-Nakano (630562), Hitoshi Suzuki (16714), Yasuyuki Nagasawa (515930), Taro Misaki (168264), Mingfeng Lee (14709760)   +11 more
core   +1 more source

Principles for Optimal Drug Selection in IgA Nephropathy—Time for Integrating Pathogenesis and Clinical Markers to Guide Therapy

Nephrology, Volume 31, Issue 2, February 2026.
ABSTRACT IgA nephropathy is a progressive glomerular disease with a variable clinical course and a substantial risk of progression to end‐stage kidney failure. While proteinuria has long been the central therapeutic target, insights into disease pathogenesis indicate that haematuria should also guide treatment decisions. Based on the pathophysiology of
Yusuke Suzuki
wiley   +1 more source

Differential expression of microRNAs in peripheral B lymphocytes in patients with IgA nephropathy and its clinical significance

Linchuang shenzangbing zazhi, 2016
Objective The aberrantly glycosylated IgA1 plays a crucial role in the pathogenesis of IgA nephropathy.In this study,we firstly identified the microRNAs expression profiles from peripheral blood B lymphocytes,and validated the differentially expressed ...
WANG Qian-liao, CHEN Ting-yu, LI Gui-sen, WANG Li   +3 more
doaj  

Proteomic Analysis of Circulating IgA1-Containing Immune Complexes in Patients with IgA Nephropathy

Kidney International Reports
Introduction: IgA1-containing immune complexes (IgA1-IC) consisting of galactose-deficient IgA1 (Gal-deficient IgA1) and IgG autoantibodies are central to the pathogenesis of IgA nephropathy (IgAN).
Mary A. Cunningham, Audra A. Hargett, Amanda K. Holloway, Stacy D. Hall, Ellenore P. Craine, Nicolas Maillard, Dana V. Rizk, Bruce A. Julian, Jan Novak, Matthew B. Renfrow   +9 more
doaj   +1 more source

Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients

Kidney & Blood Pressure Research, 2018
Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular
Petr Kosztyu, Martin Hill, Jana Jemelkova, Lydie Czernekova, Leona Raskova Kafkova, Miroslav Hruby, Karel Matousovic, Karel Vondrak, Josef Zadrazil, Ivan Sterzl, Jiri Mestecky, Milan Raska   +11 more
doaj   +1 more source

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 44-54, January 2026.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

The origin and activities of IgA1-containing immune complexes in IgA nephropathy

Frontiers in Immunology, 2016
IgA nephropathy is the most common primary glomerulonephritis, frequently leading to end-stage renal disease, as there is no disease-specific therapy.
Barbora eKnoppova, Colin eReily, Nicolas eMaillard, Dana V. Rizk, Zina eMoldoveanu, Jiri eMestecky, Milan eRaska, Milan eRaska, Matthew B. Renfrow, Bruce A. Julian, Jan eNovak   +10 more
doaj   +1 more source

Rapidly Progressive IgA Nephropathy in a Patient With a History of Breast Cancer: A Case Report and Literature Review

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
IgA nephropathy (IgAN), or Berger’s disease, is the most common primary glomerulopathy worldwide. It is characterized by dominant mesangial deposition of immunoglobulin A1 (IgA1), typically of the galactose‐deficient form (Gd‐IgA1), which triggers the formation of circulating immune complexes and subsequent glomerular inflammation.
Roger Leon Montesinos, Edwin Quispe Marca, Carla Arnez Torrico, Daniel Segura Herbas, Luis Céspedes Limachi, Zulma Tapia Arenas, Wilder Villca Mamani, Poorani Gurumallesh Prabu   +7 more
wiley   +1 more source