Results 101 to 110 of about 356,021 (162)

The role of galactose deficient IgA1 immunoglobulin in the pathogenesis, clinical presentation and progression of IgA nephropathy

, 2022
Aim of the present study was to investigate whether the determination of the galactose-deficient IgA1 levels and the expression of miRNAs let-7b and miR-148b could contribute to the diagnosis of IgA nephropathy before performing a renal biopsy, or if ...
Kouri, Nikoletta-Maria, Κουρή, Νικολέττα-Μαρία   +1 more
core   +1 more source

Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy

Renal Failure, 2019
Background: Recent genomewide association study suggested that the top single-nucleotide polymorphism, rs978056, in HECW1 gene (which encodes HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) associated with the levels of galactose ...
Youxia Liu, Jie Zheng, Junya Jia, Hongfen Li, Shuiyi Hu, Yujia Lin, Tiekun Yan   +6 more
doaj   +1 more source

Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy

PLOS ONE, 2016
Galactose-deficient IgA1 (Gd-IgA1) and IgA-IgG complexes are known to play an important role in the pathogenesis of IgA nephropathy (IgAN). We aimed therefore to determine the impact of immunosuppression on the serum levels of Gd-IgA1, total IgA1 and IgA-IgG complexes in IgAN patients.
Kim, M. J., Schaub, S., Molyneux, Karen, Koller, M. T., Stampf, S., Barratt, Jonathan   +5 more
openaire   +6 more sources

Serum and urine galactose deficient-IgA1 as alternative biomarkers in the management of IgA nephropathy [PDF]

Introduction: Immunoglobulin A (IgA) nephropathy (IgAN) results from abnormal accumulation of immune complexes containing galactose deficient IgA1 (Gd-IgA1) in the kidneys.
Zakaria, Nor Fadhlina, Abd Ghani, Fauzah, Hod, Rafidah, Suleman-alabi, Aminat   +3 more
core   +1 more source

SP124GLOMERULAR GALACTOSE-DEFICIENT IGA1 IS SPECIFIC FOR IGA NEPHROPATHY [PDF]

Nephrology Dialysis Transplantation, 2016
Hitoshi Suzuki, Yuko Makita, Miyuki Takagi, Toshiki Kano, Chieko Nogi, Akiko Takahata, Yusuke Suzuki   +6 more
openaire   +1 more source

IgA肾病发病机制研究纵览

Linchuang shenzangbing zazhi, 2016
IgA肾病是1968年由法国学者Berger和Hinglais首先描述和命名的,因此也称为Berger病,该病早期主要病理变化为多聚体低糖基化IgA1免疫复合物(polymer galactose-deficient IgA1 immune complexes,pGd-IgA1-IC)在肾小球系膜区沉积。IgA肾病是世界范围内公认最常见的原发性肾小球疾病 ...
李慧琼, 刘帝, 刘烨歆, 谭夏, 贺理宇, 王畅, 刘虹   +6 more
doaj  

Aberrant signaling in tonsillar B cells producing pathogenic O-glycoforms of IgA1 in IgA nephropathy

Frontiers in Immunology
IgA nephropathy (IgAN) is a mesangioproliferative glomerulonephritis characterized by IgA1-containing immune-complex deposits wherein IgA1 is enriched for galactose-deficient IgA1 (Gd-IgA1) glycoforms. IgAN pathogenesis involves mucosal immune system, as
Koshi Yamada, Kei Ogiwara, Jan Novak, Yusuke Suzuki   +3 more
doaj   +1 more source

Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy

BMC Nephrology, 2017
Background Accumulating evidences proved the important roles of circulating IgA1-containing immune complexes (cIgA1) in IgA nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) and glycan-specific IgG antibody have been identified as major components ...
Yan-feng Zhao, Li Zhu, Li-jun Liu, Su-fang Shi, Ji-cheng Lv, Hong Zhang   +5 more
doaj   +1 more source

Diagnostic and prognostic value of galactose-deficient IgA1 in patients with IgA nephropathy: an updated systematic review with meta-analysis. [PDF]

Front Immunol, 2023
Zeng Q, Wang WR, Li YH, Liang Y, Wang XH, Yan L, Yu RH.   +6 more
europepmc   +1 more source

Microplastics and IgA nephropathy: a novel environmental hypothesis of immune dysregulation

Renal Failure
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by a 4-hit pathogenesis primarily driven by mucosal immune dysregulation in the gut-associated lymphoid tissue (GALT).
Joel Shah, William Wells-Gatnik, Biff F. Palmer, Deborah J. Clegg   +3 more
doaj   +1 more source