Results 91 to 100 of about 356,021 (162)

Study on the relationship between plasma Gd-IgA1 concentration and disease severity in IgA nephropathy and its production mechanism

Linchuang shenzangbing zazhi, 2020
Objective To determine the relationship between the level of plasma Gd-IgA1(galactose-deficient IgA1) and disease severity in IgA nephropathy(IgAN) patients, and to explore the possible mechanism of abnormal glycosylation of IgA1 from the perspective of ...
DAI Qin, MIAO Yi, WANG Wei-ming
doaj  

Minimal Change Disease With Mesangial IgA Deposition: A Clinicopathological Case Series From a Tunisian Referral Center

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Background Minimal change disease (MCD) associated with mesangial immunoglobulin A (IgA) deposition, historically referred to as “IgA Nephrosis,” is a rare and nosologically controversial entity. Whether it represents MCD with incidental mesangial IgA deposition, a dual glomerulopathy combining MCD and subclinical IgA nephropathy (IgAN), or a distinct ...
Meriam Hajji, Ilhem Ben Othman, Abir Boussetta, Rihab Zouaoui, Nada Sellami, Hayet Kaaroud, Taher Gargueh, Ezzeddine Abderrahim, Poorani Gurumallesh Prabu   +8 more
wiley   +1 more source

Combination of Mendelian Randomization and Transcriptomes to Identify Causal Genes Associated With IgAN

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Background IgA nephropathy (IgAN) represents the most common form of primary glomerulonephritis worldwide, contributing substantially to chronic renal impairment and end‐stage kidney failure. The present study utilized bioinformatics methodologies to screen for pivotal genes involved in IgAN development.
Kunpeng Bu, Peigeng He, Yue Wu, Qingfeng Song, Dawei Cui   +4 more
wiley   +1 more source

Research advances Progress in the pathogenesis of IgA nephropathy

Linchuang shenzangbing zazhi
As the most common primary glomerular disease in the world, IgA nephropathy (IgAN) is one of the major causes of end-stage renal disease (ESRD). With the in-depth studies of IgAN, researchers have gradually clarified the important roles of galactose ...
Fei-fei Wang, Ling-xu Li, Chun-miao Chen, Xiao-ying Yun, Bing Li   +4 more
doaj   +1 more source

Relevance of Serum Galactose Deficient IgA1 in predicting the prognosis of patients with IgA Nephropathy: a systematic review and meta-analysis

, 2022
This Systematic Review aims to answer if serum Galactose Deficient IgA1 (Gd-IgA1), which is essential to the pathogenesis of IgA Nephropathy, correlates with clinical data and predicts the prognosis of patients affected by the disease.
Ana Cristina Simões e Silva, Pedro Alves Soares Vaz de Castro, Arthur Aguiar Amaral, Mariana Godinho   +3 more
core   +1 more source

Correlation of Serum Galactose-Deficient IgA1 and Oxford Class in Cases of IgA Nephropathy

Archives of Pathology & Laboratory Medicine
Context.— Galactose-deficient immunoglobulin A1 (Gd-IgA1) deposition in the renal mesangium plays a role in the pathogenesis of IgA nephropathy. Objective.— To assess the serum Gd-IgA1 level in biopsy-proven IgA nephropathy cases at ...
Monika, Shukla, Kiran Preet, Malhotra, Abhilash, Chandra, Namrata Sarvepalli, Rao, Mohammad Kaleem, Ahmad   +4 more
openaire   +2 more sources

Deciphering the Underlying Mechanisms Linking Psoriasis and IgA Nephropathy

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Psoriasis is a chronic, immune‐mediated inflammatory disease with systemic manifestations that include renal complications. Immunoglobulin A nephropathy (IgAN) represents the most common autoimmune glomerular disease worldwide. Growing epidemiological and genetic evidence supports a clinically relevant association between psoriasis and IgAN ...
Zijie Tang, Jintong Wu, Meihan Dong, Chengxin Li, Rui Wang, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

Gd-IgA1-targeting therapy in IgA nephropathy ~what is pathogenic Gd-IgA1?~

Frontiers in Nephrology
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, and galactose-deficient IgA1 (Gd-IgA1) is widely recognized as the central pathogenic molecule in the current multi-hit model of IgAN.
Kazuaki Mori, Yoshihito Nihei, Yusuke Suzuki   +2 more
doaj   +1 more source

Serum galactose-deficient IgA1 levels in children with IgA nephropathy.

International journal of clinical and experimental medicine, 2015
Immunoglobulin A nephropathy (IgAN) is an immunopathologic diagnosis based on a renal biopsy, it is characterized by deposits of IgA-containing immune complexes in the mesangium. Adults with IgAN have a galactose-deficient IgA1 in the circulation and glomerular deposition.
Mengjie, Jiang, Xiaoyun, Jiang, Liping, Rong, Yuanyuan, Xu, Lizhi, Chen, Zeting, Qiu, Ying, Mo   +6 more
openaire   +1 more source

Supplementary Material for: Clinical Significance of Galactose-Deficient IgA1 by KM55 in Patients with IgA Nephropathy

, 2019
Background: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. A monoclonal antibody, KM55, which specifically recognizes Gd-
Yan T. (3089994), Zhang K. (2881757), Shang W. (7448825), Li Q. (2850350), Jia J. (3665533), Li H. (2886434), Wei L. (4146940), Liu Y. (597977), Gao S. (3341019), Zhang Y. (2828780), Lin S. (3642448)   +10 more
core   +1 more source