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Galactose disorders: An overview

Journal of Inherited Metabolic Disease, 1990
SummaryThere are three separate disorders of galactose metabolism of clinical importance. Galactokinase deficiency mainly causes cataracts which regress without complications providing a galactose‐free diet is started early enough. UDPgalactose‐4‐epimerase deficiency seems extremely rare.
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Galactose oxidase

2002
The free radical-coupled copper catalytic motif has emerged as the unifying feature of a new family of enzymes, the radical copper oxidases. Their highly evolved active sites include a novel amino acid modification, the Tyr-Cys dimer, that forms spontaneously through self-processing of the protein during its maturation. The active site is remarkable in
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Galactose alpha 1-3 galactose and anti-alpha galactose antibody in normal and pathological pregnancies

Placenta, 1992
The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor cells, we have examined the possibility of their expression on human trophoblastic cells at different stages of placental implantation and in various ...
Y, Christiane   +5 more
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Glucose-galactose malabsorption

The Journal of Pediatrics, 1966
This is the first report in the American literature of a patient with a deficiency of gastrointestinal absorption of glucose and galactose. The disease is characterized by severe, chronic, watery diarrhea starting soon after birth. Marked improvement occurs following the substitution of the offending sugars by fructose.
J F, Marks, J B, Norton, J S, Fordtran
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CONCENTRATION OF GALACTOSE BY LEUCOCYTES

Canadian Journal of Biochemistry and Physiology, 1963
Leucocytes suspended in native plasma took up galactose and held it within the cells at a concentration 3–6 times greater than that in the plasma. Conversion to galactose-1-phosphate, uridinediphosphogalactose, and other, unidentified compounds occurred. The accumulation of galactose was not impaired in diabetes, and was not influenced by insulin.
N, KALANT, R, SCHUCHER
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Mutations in the galactose-operator

Molecular and General Genetics MGG, 1970
Constitutive mutations in the galactose operator in E. coli arise with a frequency ten times smaller than in the regulator gene. The operator constitutive mutations do not arise as a consequence of mutagen treatment. Operator constitutive mutations do not revert to wildtype spontaneously or after mutagen treatment.
L, Fiethen, P, Starlinger
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Intestinal absorption of galactose

Biochimica et Biophysica Acta, 1960
Abstract Galactose absorption from the rat intestine was studied in the intact animal, in the perfused intestine and in the isolated intestinal loop. In the intact animal an average porto-arterial difference of 16.1 milligram per cent galactose was found. At the same time there was no porto-arterial difference in the total reducing sugar.
R, TZUR, B, SHAPIRO
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Galactose

2000
Abstract The impact of galactose toxicity depends on the particular pathway of galactose metabolism present in various cells and the structure of the tissues and organs containing these cells. Experimental studies using high-galactose diets have demonstrated toxic complications in tissues of the eye, liver, kidney, gonads, and ...
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Galactose Utilization in Galactosemia

Science, 1972
Cultures of human galactosemic fibroblasts without detectable transferase activity were able to convert [1- 14 C]galactose to 14 CO 2 to the same extent as normal cells, but did so at a significantly slower rate.
J C, Petricciani   +3 more
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Galactose 1-phosphate in galactose cataract

Biochimica et Biophysica Acta, 1955
Y, SCHWARZ, L, GOLBERG
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