Small, EarlyView.This review provides a systematic overview of the field of antibacterial PhotoDynamic Therapy (aPDT) triggered by upconversion nanoparticles (UCNPs), focusing on the mechanisms and the key factors that define their efficacy for generating bactericidal species upon NIR‐light activation.
Zhe Li +3 more
wiley +1 more source
D-galactose enhances Maillard reaction and antioxidant activity of arginine-derived products: experimental and molecular insights. [PDF]
Front NutrDing Y, Fan X, Zhou J, Wu Y, Rao P.
europepmc +1 more source
A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance
Small, EarlyView.Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib +10 more
wiley +1 more source
Citrin Deficiency: Biochemical Mechanisms Underlying a Complex Hepatic Metabolic Disorder. [PDF]
BiomoleculesGarcía-Lobo I +3 more
europepmc +1 more source
Synthetic Cells With Chemo‐Optical Signaling Enable Targeted Capture and Killing of Bacteria
Small, EarlyView.The here presented synthetic cells capture bacteria through their internally produced bioluminescence signal and light activated adhesions. Subsequently, they eliminate the captured bacteria in through a locally elevated hydrogen peroxide concentration generated by membrane bound enzyme.
Xiaoran Zheng +4 more
wiley +1 more source
Smart Molecules, EarlyView.A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song +6 more
wiley +1 more source
High Resolution Ion Mobility Enables the Separation of α-Galactose Containing Glycans from Their Non-α-Galactose Isomers. [PDF]
J Biomol TechPark K, Orlando R.
europepmc +1 more source
Smart Molecules, EarlyView.We developed a lipophilic near‑infrared probe (DCIP‑AcGal) that is specifically activated by senescence‑associated β‑galactosidase. After intravenous injection, it lights up therapy‑induced tumor senescence in living mice. Its optimized lipophilicity also enables blood‑brain barrier crossing to detect natural brain senescence ex vivo. This probe offers
Jiani Huang +15 more
wiley +1 more source
Co-Supplementation of Policosanol and Atorvastatin Attenuates High-Cholesterol and High-Galactose Diet-Induced Ocular and Brain Damage and Improves Cognitive Health in Zebrafish. [PDF]
Pharmaceuticals (Basel)Cho KH, Bahuguna A, Baek SH, Yang CE.
europepmc +1 more source
Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source