Results 61 to 70 of about 184,426 (243)
Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy
Advanced Science, EarlyView.An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Mengyang Chang +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu +7 more
wiley +2 more sources
Scientific Papers Animal Science and Biotechnologies, 2023 The aim of our paper was to make a series of experiments in order to determine the concentration at which four cryoprotectants (DMSO, sucrose, Ficoll 70 and galactose) singly and in pairs would vitrify on plunging into liquid nitrogen and remain vitreous
ADA TELEA +4 more
doaj
Advanced Science, EarlyView.A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao +11 more
wiley +1 more source
Síntese de um novo complexo de cobre modelo para o sitio ativo da galactose oxidase [PDF]
, 2002 TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.A química bioinorgânica tem por objetivo compreender a estrutura e a atividade de metaloenzimas.
Sousa, Rafael Jovito
core
Role of anterior segment optical coherence tomogram in Descemet′s membrane detachment
Indian Journal of Ophthalmology, 2011 Descemet′s membrane detachment (DD) is a rare but serious complication of intraocular surgery. In rare cases where corneal edema is severe and we may not be able to visualize DD on slit-lamp examination, anterior segment optical coherence tomogram (AS ...
Sonia Kothari +2 more
doaj +1 more source
Advanced Science, EarlyView.Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le +13 more
wiley +1 more source
VirulenceSalmonella enteritidis is a globally prevalent zoonotic pathogen with a broad host range and high pathogenicity, ranking among the most common serotypes within the Salmonella genus.
Xia Li +4 more
doaj +1 more source
Advanced Science, EarlyView.An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song +5 more
wiley +1 more source
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source