Results 151 to 160 of about 14,424 (294)

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

open access: yesAging Cell, EarlyView.
In male patients undergoing CABG surgery, pretreatment with quercetin suppressed inflammaging and its associated inflammation, leading to improved endothelium‐dependent relaxation (measured ex vivo) and reducing new onset of post‐operative atrial fibrillation.
Pauline Mury   +19 more
wiley   +1 more source

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

open access: yesAging Cell, EarlyView.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar   +18 more
wiley   +1 more source

Structural insight into the hydrolase and synthase activities of an alkaline α-galactosidase from Arabidopsis from complexes with substrate/product. [PDF]

open access: yesActa Crystallogr D Struct Biol, 2023
Chuankhayan P   +8 more
europepmc   +1 more source

Metformin and Dietary Restriction Counteract Aging via Reducing m6A–Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

open access: yesAging Cell, EarlyView.
Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang   +8 more
wiley   +1 more source

Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging

open access: yesAging Cell, EarlyView.
BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong   +4 more
wiley   +1 more source

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