Results 161 to 170 of about 14,424 (294)

Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype

open access: yesAging Cell, EarlyView.
This study reveals that in vitro senescence induction methods significantly influence intracellular biomolecular profiles, showing both shared and unique metabolic responses. A novel bioanalytical pipeline was developed to explore these subphenotypes, highlighting the importance of targeting metabolic redox circuits and serine/taurine pathways for ...
Domenica Berardi   +11 more
wiley   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

open access: yesAging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini   +14 more
wiley   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

open access: yesAging Cell, EarlyView.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang   +6 more
wiley   +1 more source

Some Enzymic Properties of a Microbial beta-Galactosidase of Human Whole Saliva. [PDF]

open access: bronze, 1968
Kauko K. Mäkinen   +3 more
openalex   +1 more source

Virus‐Induced Cellular Senescence Causes Pulmonary Sequelae Post‐Influenza Infection

open access: yesAging Cell, EarlyView.
Genetic or pharmacological depletion of senescent cells during influenza A virus infection led to complete recovery of the airway epithelium, indicating a marked acceleration of the epithelial repair process. Targeting senescent cells may represent a new preventive therapeutic option to reduce post‐influenza chronic lung damage.
Larissa Lipskaia   +20 more
wiley   +1 more source

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